The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Bcl‐2 and Bcl‐xL play important roles in the crosstalk between autophagy and apoptosis
Abstract
Autophagy and apoptosis play important roles in the development, cellular homeostasis and, especially, oncogenesis of mammals. They may be triggered by common upstream signals, resulting in combined autophagy and apoptosis. In other instances, they may be mutually exclusive. Recent studies have suggested possible molecular mechanisms for crosstalk between autophagy and apoptosis. Bcl‐2 and Bcl‐xL, the well‐characterized apoptosis guards, appear to be important factors in autophagy, inhibiting Beclin 1‐mediated autophagy by binding to Beclin 1. In addition, Beclin 1, Bcl‐2 and Bcl‐xL can cooperate with Atg5 or Ca 2+ to regulate both autophagy and apoptosis. Thus, Bcl‐2 and Bcl‐xL represent a molecular link between autophagy and apoptosis. Here, we discuss the possible roles of Bcl‐2 and Bcl‐xL in apoptosis and autophagy, and the crosstalk between them.
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Sui, X., Kong, N., Ye, L., Han, W., Zhou, J., Zhang, Q., He, C., & Pan, H. (2014) · Cancer Letters · doi:10.1016/j.canlet.2013.11.019 · Cited by 958
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Taddei, M., Giannoni, E., Fiaschi, T., & Chiarugi, P. (2012) · The Journal of Pathology · doi:10.1002/path.3000 · Cited by 716
Autophagy and apoptosis: where do they meet?
Mukhopadhyay, S., Panda, P. K., Sinha, N., Das, D. N., & Bhutia, S. K. (2014) · Apoptosis · doi:10.1007/s10495-014-0967-2 · Cited by 572
Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease
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Metadata
- Authors
- Zhou, F., Yang, Y., & Xing, D.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2010-12-23
- Volume
- 278
- Issue
- 3
- Pages
- 403-413
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W1563936556
- Cited by
- 424
- References
- 87
- FWCI
- 23.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhou, F., Yang, Y., & Xing, D. (2011). Bcl‐2 and Bcl‐xL play important roles in the crosstalk between autophagy and apoptosis. The FEBS Journal. https://doi.org/10.1111/j.1742-4658.2010.07965.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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