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The ins and outs of pertussis toxin
Abstract
Pertussis toxin, produced and secreted by the whooping cough agent Bordetella pertussis, is one of the most complex soluble bacterial proteins. It is actively secreted through the B. pertussis cell envelope by the Ptl secretion system, a member of the widespread type IV secretion systems. The toxin is composed of five subunits (named S1 to S5 according to their decreasing molecular weights) arranged in an A–B structure. The A protomer is composed of the enzymatically active S1 subunit, which catalyzes ADP‐ribosylation of the α subunit of trimeric G proteins, thereby disturbing the metabolic functions of the target cells, leading to a variety of biological activities. The B oligomer is composed of 1S2:1S3:2S4:1S5 and is responsible for binding of the toxin to the target cell receptors and for intracellular trafficking via receptor‐mediated endocytosis and retrograde transport. The toxin is one of the most important virulence factors of B. pertussis and is a component of all current vaccines against whooping cough.
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Cited by
Guo, S., Perets, N., Betzer, O., Ben-Shaul, S., Sheinin, A., Michaelevski, I., Popovtzer, R., Offen, D., & Levenberg, S. (2019) · ACS Nano · doi:10.1021/acsnano.9b01892 · Cited by 424
Perets, N., Betzer, O., Shapira, R., Brenstein, S., Angel, A., Sadan, T., Ashery, U., Popovtzer, R., & Offen, D. (2019) · Nano Letters · doi:10.1021/acs.nanolett.8b04148 · Cited by 382
Mechanism and structure of the bacterial type IV secretion systems
Christie, P. J., Whitaker, N., & González-Rivera, C. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.12.019 · Cited by 280
Bacterial killing via a type IV secretion system
Souza, D. P., Oka, G. U., Alvarez-Martinez, C. E., Bisson-Filho, A. W., Dunger, G., Hobeika, L., Cavalcante, N. S., Alegria, M. C., Barbosa, L. R. S., Salinas, R. K., et al. (2015) · Nature Communications · doi:10.1038/ncomms7453 · Cited by 271
Ahmad, J. N., Holubova, J., Benada, O., Kofronova, O., Stehlik, L., Vasakova, M., & Sebo, P. (2019) · mBio · doi:10.1128/mbio.01743-19 · Cited by 38
Metadata
- Authors
- Locht, C., Coutte, L., & Mielcarek, N.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2011-08-04
- Volume
- 278
- Issue
- 23
- Pages
- 4668-4682
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2099827287
- Cited by
- 190
- References
- 0
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Locht, C., Coutte, L., & Mielcarek, N. (2011). The ins and outs of pertussis toxin. The FEBS Journal. https://doi.org/10.1111/j.1742-4658.2011.08237.x
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