The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Mechanism and structure of the bacterial type IV secretion systems
Open accessAbstract
The bacterial type IV secretion systems (T4SSs) translocate DNA and protein substrates to bacterial or eukaryotic target cells generally by a mechanism dependent on direct cell-to-cell contact. The T4SSs encompass two large subfamilies, the conjugation systems and the effector translocators. The conjugation systems mediate interbacterial DNA transfer and are responsible for the rapid dissemination of antibiotic resistance genes and virulence determinants in clinical settings. The effector translocators are used by many Gram-negative bacterial pathogens for delivery of potentially hundreds of virulence proteins to eukaryotic cells for modulation of different physiological processes during infection. Recently, there has been considerable progress in defining the structures of T4SS machine subunits and large machine subassemblies. Additionally, the nature of substrate translocation sequences and the contributions of accessory proteins to substrate docking with the translocation channel have been elucidated. A DNA translocation route through the Agrobacterium tumefaciens VirB/VirD4 system was defined, and both intracellular (DNA ligand, ATP energy) and extracellular (phage binding) signals were shown to activate type IV-dependent translocation. Finally, phylogenetic studies have shed light on the evolution and distribution of T4SSs, and complementary structure-function studies of diverse systems have identified adaptations tailored for novel functions in pathogenic settings. This review summarizes the recent progress in our understanding of the architecture and mechanism of action of these fascinating machines, with emphasis on the ‘archetypal’ A. tumefaciens VirB/VirD4 T4SS and related conjugation systems.
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UCSF Chimera—A visualization system for exploratory research and analysis
Pettersen, E. F., Goddard, T. D., Huang, C. C., Couch, G. S., Greenblatt, D. M., Meng, E. C., & Ferrin, T. E. (2004) · Journal of Computational Chemistry · doi:10.1002/jcc.20084 · Cited by 45,828
Translocation of Helicobacter pylori CagA into Gastric Epithelial Cells by Type IV Secretion
Odenbreit, S., Püls, J., Sedlmaier, B., Gerland, E., Fischer, W., & Haas, R. (2000) · Science · doi:10.1126/science.287.5457.1497 · Cited by 1,286
Genomic islands: tools of bacterial horizontal gene transfer and evolution
Juhas, M., van der Meer, J. R., Gaillard, M., Harding, R. M., Hood, D. W., & Crook, D. W. (2009) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00136.x · Cited by 969
Biological Diversity of Prokaryotic Type IV Secretion Systems
Alvarez-Martinez, C. E., & Christie, P. J. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00023-09 · Cited by 729
Self-citationThe versatile bacterial type IV secretion systems
Cascales, E., & Christie, P. J. (2003) · Nature Reviews Microbiology · doi:10.1038/nrmicro753 · Cited by 694
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Christie, P. J., Atmakuri, K., Krishnamoorthy, V., Jakubowski, S., & Cascales, E. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123630 · Cited by 630
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Akeda, Y., & Galán, J. E. (2005) · Nature · doi:10.1038/nature03992 · Cited by 456
O'Callaghan, D., Cazevieille, C., Allardet‐Servent, A., Boschiroli, M. L., Bourg, G., Foulongne, V., Frutos, P., Kulakov, Y., & Ramuz, M. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01569.x · Cited by 441
Modulation of Host Cell Function by Legionella pneumophila Type IV Effectors
Hubber, A., & Roy, C. R. (2010) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100109-104034 · Cited by 431
F factor conjugation is a true type IV secretion system
Lawley, T. D., Klimke, W. A., Gubbins, M. J., & Frost, L. S. (2003) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(03)00430-0 · Cited by 426
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Metadata
- Authors
- Christie, P. J., Whitaker, N., & González-Rivera, C.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 1843
- Issue
- 8
- Pages
- 1578-1591
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2036467696
- Cited by
- 280
- References
- 112
- FWCI
- 19.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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