The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Differential Inhibitory Effects of the Polyphenol Ellagic Acid on Inflammatory Mediators NF‐κB, iNOS, COX‐2, TNF‐α, and IL‐6 in 1,2‐Dimethylhydrazine‐Induced Rat Colon Carcinogenesis
Open accessAbstract
Abstract: Dietary polyphenols have been found to possess preventive and therapeutic potential against several types of cancers. We investigated the effect of ellagic acid on colon cancer induced by 1,2‐dimethylhydrazine in rats. Male Wistar albino rats were divided into four groups. Group 1 served as control, group 2 rats received ellagic acid 60 mg/kg bodyweight/every day p.o. throughout the experiment. Rats from groups 3 and 4 were given subcutaneous (s.c.) injections of 1,2‐dimethylhydrazine (20 mg/kg body weight) once a week for the first 15 weeks; rats in group 4 received ellagic acid as in group 2 after the last injection of 1,2‐dimethylhydrazine and continued till the end of the experimental period of 30 weeks. 1,2‐dimethylhydrazine‐induced rats exhibited alterations in cancer tumour markers [5′‐nucleotidase (5′‐ND), gamma glutamyl transpeptidase (γ‐GT), carcinoembryonic antigen (CEA), alphafetoprotein (AFP) and cathepsin‐D (CD)]; pathophysiological markers [alkaline phosphatase (ALP) and lactate dehydrogenase (LDH)] and oral administration of ellagic acid restored the levels of these marker enzymes. Nuclear factor‐kappa B (NF‐κB) actively involved in the regulation of both pro‐inflammatory proteins [inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX‐2)] and pro‐inflammatory cytokines [tumour necrosis factor (TNF)‐α and interleukin (IL)‐6] and in our study 1,2‐dimethylhydrazine‐induced group exhibited elevated expressions of all these inflammatory proteins. Ellagic acid administration reduced the expressions of NF‐κB, COX‐2, iNOS, TNF‐α and IL‐6 as confirmed by immunohistochemical, immunoblot and immunofluorescence analysis during 1,2‐dimethylhydrazine‐induced colon carcinogenesis. In conclusion, ellagic acid demonstrates anti‐inflammatory property by iNOS, COX‐2, TNF‐α and IL‐6 down‐regulation due to inhibition of NF‐κB and exerts its chemopreventive effect on colon carcinogenesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The role of cyclooxygenases in inflammation, cancer, and development
Williams, C. S., Mann, M., & DuBois, R. N. (1999) · Oncogene · doi:10.1038/sj.onc.1203286 · Cited by 1,417
Cited by
Targeting arachidonic acid pathway by natural products for cancer prevention and therapy
Yarla, N. S., Bishayee, A., Sethi, G., Reddanna, P., Kalle, A. M., Dhananjaya, B. L., Dowluru, K. S. V. G. K., Chintala, R., & Duddukuri, G. R. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.02.001 · Cited by 364
Dietary polyphenol impact on gut health and microbiota
Wan, M. L. Y., Co, V. A., & El-Nezami, H. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1744512 · Cited by 325
Strawberry As a Functional Food: An Evidence-Based Review
Basu, A., Nguyen, A., Betts, N. M., & Lyons, T. J. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.608174 · Cited by 312
Ellagic acid: Pharmacological activities and molecular mechanisms involved in liver protection
García-Niño, W. R., & Zazueta, C. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.04.008 · Cited by 274
AlAli, M., Alqubaisy, M., Aljaafari, M. N., AlAli, A. O., Baqais, L., Molouki, A., Abushelaibi, A., Lai, K.-S., & Lim, S.-H. E. (2021) · Molecules · doi:10.3390/molecules26092540 · Cited by 253
Metadata
- Authors
- Umesalma, S., & Sudhandiran, G.
- Venue
- Basic & Clinical Pharmacology & Toxicology
- Publisher
- Wiley
- Published
- 2010-07-14
- Volume
- 107
- Issue
- 2
- Pages
- 650-655
- ISSN
- 1742-7835 (ISSN-L)
- 1742-7843
- OpenAlex
- W1995654099
- Cited by
- 232
- References
- 1
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Differential Inhibitory Effects of the Polyphenol Ellagic Acid on Inflammatory Mediators NF‐κB, iNOS, COX‐2, TNF‐α, and IL‐6 in 1,2‐Dimethylhydrazine‐Induced Rat Colon Carcinogenesis. https://app.cochat.ai/papers/10.1111/j.1742-7843.2010.00565.x
- The paper
- Umesalma, S., & Sudhandiran, G. (2010). Differential Inhibitory Effects of the Polyphenol Ellagic Acid on Inflammatory Mediators NF‐κB, iNOS, COX‐2, TNF‐α, and IL‐6 in 1,2‐Dimethylhydrazine‐Induced Rat Colon Carcinogenesis. Basic & Clinical Pharmacology & Toxicology. https://doi.org/10.1111/j.1742-7843.2010.00565.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
