Effects of weight loss intervention on erectile function in older men with type 2 diabetes in the Look AHEAD trial
Open accessAbstract
INTRODUCTION: Overweight men with diabetes often report erectile dysfunction (ED), but few studies have examined effects of weight loss on this problem. AIM: This study examined 1-year changes in erectile function (EF) in overweight/obese men with type 2 diabetes participating in the Look AHEAD (Action for Health in Diabetes) trial. METHODS: Participants in Look AHEAD were randomly assigned to a control condition involving diabetes support and education (DSE) or to intensive lifestyle intervention (ILI) involving group and individual sessions to reduce weight and increase physical activity. Men from five of the clinical sites in Look AHEAD completed the International Index of Erectile Function (IIEF) at baseline (N = 372) and at 1 year (N = 306) (82%). MAIN OUTCOME MEASURES: Changes in EF as reported on the EF subscale of the IIEF. RESULTS: At 1 year, the ILI group lost a greater percent of initial body weight (9.9% vs. 0.6 %) and had greater improvements in fitness (22.7% vs. 4.6%) than DSE. EF improved more in ILI (17.3 +/- 7.6 at baseline; 18.6 +/- 8.1 at 1 year) than in DSE (18.3 +/- 7.6 at baseline; 18.4 +/- 8.0 at 1 year); P = 0.04 and P = 0.06 after adjusting for baseline differences. Using established norms for none (i.e., normal EF), and three grades (i.e., mild, moderate, and severe) ED, 8% of men in ILI reported a worsening of EF from baseline to 1 year, 70% stayed in the same category, and 22% reported improvements. In contrast, 20% of DSE reported worsening, 57% stayed in the same category, and 23% improved (P = 0.006). CONCLUSION: In this sample of older overweight/obese diabetic men, weight loss intervention was mildly helpful in maintaining EF.
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In older diabetic men, weight loss (9.9%) increased the IIEF score by 1.3 relative to controls.
“In older diabetic men (24), weight loss (9.9%) increased the IIEF score by 1.3 relative to controls.”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [24]
The reduced efficacy of weight loss for erectile dysfunction in older diabetic men was likely due to higher rates of irreversible erectile dysfunction due to neurovascular disease.
“This reduced efficacy in older diabetic men was likely due to higher rates of irreversible erectile dysfunction due to neurovascular disease (24).”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [24]
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- Authors
- Wing, R. R., Rosen, R. C., Fava, J. L., Bahnson, J., Brancati, F., Gendrano, I. N. C., Kitabchi, A., Schneider, S. H., & Wadden, T. A.
- Affiliations
- Miriam Hospital (US)
- New England Research Institutes (US)
- Wake Forest University Health Sciences (US)
- Johns Hopkins University (US)
- University of Medicine and Dentistry of New Jersey (US)
- University of Tennessee Health Science Center (US)
- University of Pennsylvania (US)
- Corresponding author
- Wing, Rena R.
- Venue
- The Journal of Sexual Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-01-01
- Volume
- 7
- Issue
- 1_Part_1
- Pages
- 156-165
- ISSN
- 1743-6095 (ISSN-L)
- 1743-6109
- PMC
- PMC4461030
- OpenAlex
- W2010688718
- Cited by
- 180
- References
- 27
- Citations by year
- 2026: 10 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 8 · 2021: 10 · 2020: 14 · 2019: 12 · 2018: 11 · 2017: 14 · 2016: 20 · 2015: 14 · 2014: 16 · 2013: 9 · 2012: 12
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- The Journal of Sexual Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01 DK60438, DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135, DK56992)
- The Johns Hopkins Medical Institutions Bayview General Clinical Research Center (M01RR02719)
- Massachusetts General Hospital Mallinckrodt General Clinical Research Center (M01RR01066)
- Clinical Nutrition Research Unit (P30 DK48520)
- University of Tennessee at Memphis General Clinical Research Center (M01RR0021140)
- University of Pittsburgh General Clinical Research Center (M01RR000056 44)
- NIH (DK 046204)
- University of Washington / VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs; Frederic C. Bartter General Clinical Research Center (M01RR01346)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- erectile dysfunction, weight loss, type 2 diabetes, older men, intensive lifestyle intervention, diabetes support and education, obesity, overweight, physical activity, Look AHEAD trial, International Index of Erectile Function
- MeSH terms
- Aged, Energy Intake, Combined Modality Therapy, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Diet, Reducing, Humans, Erectile Dysfunction, Life Style, Male, Middle Aged, Motor Activity, Obesity, Patient Education as Topic, Physical Fitness, Weight Loss, Health Behavior, Body Mass Index, Overweight
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