The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
Couples' reasons for adherence to, or discontinuation of, PDE type 5 inhibitors for men with erectile dysfunction at 12 to 24-month follow-up after a 6-month free trial
Abstract
INTRODUCTION: The history of treatments for erectile dysfunction (ED) has involved a repeated pattern of uptake, followed by abandonment of the various therapies in the medium term. Even effective and simple to use medications are not necessarily continued; discontinuation rates range between 15% and 60%. Despite the association between partner sexual function and men's use of PDE5, no previous studies have reported any contact with partners of men taking PDE5 for their ED. This study involved both partners in couples followed up at least 1 year after treatment of ED. AIM: The study sought clarification of factors influencing adherence to, or discontinuation of, oral ED medications from couples. We hypothesized that many factors contribute to decision making about ED medication use at >12 months. MAIN OUTCOME MEASURES: The main outcome measures of this article were interviews and International Index of Erectile Function-erectile function domain. METHODS: A total of 155 interviews were conducted seeking details of frequency of usage and preference for the drugs available; reasons for that choice, or for discontinuation of use, were also sought. RESULTS: Of men interviewed, 71% were using PDE5 at 18 months. Most men interviewed were using the oral medications either 1-2x/week or 1-2x/month. Forty-four percent of men who had decreased their use of the medications reported less need for them. Thirty-four men said the main reason they were using less medication was cost. "Partner issues" from the men's perspective were seldom reported in this study. However, for a number of women, "partner issues" meant a range of problems from separation to alcohol abuse, lack of communication, and lack of confidence, or fear of failure. CONCLUSIONS: This is the first study to ask couples why they decided to continue or stop using PDE5 when followed up. Female partners provided a different perspective on "partner issues" often cited as reasons for discontinuing PDE5 use. It was also clear that discontinuation did not mean couples were no longer sexually active.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Psychological treatment may help promote treatment adherence, integrate medical aids into the sexual relationship, and resolve psychological correlates such as anxiety, negative thoughts, distress, self-confidence, intimacy, and communication problems.
“Psychological treatment may help to promote treatment adherence, integrate the treatment (ie, medical aids) into the sexual relationship and resolve psychological correlates such anxiety, negative thoughts, distress, self-confidence, intimacy, and communication problems between partners.59,109”
From A Psychosocial Approach to Erectile Dysfunction: Position Statements from the European Society of Sexual Medicine (ESSM) (2021) · cites this paper as [59]
Barriers to seeking treatment for ED include embarrassment, communication problems between partners, low self-confidence, self and partner blaming, feeling older, inaccurate information, and limited understanding of ED.
“Research has identified several barriers to seeking treatment for ED. In addition to feeling embarrassed, communication problems between partners, low self-confidence, self and partner blaming, and feeling older, also inaccurate information and limited understanding of ED may prevent men and their partners from seeking help.59,96,97”
From A Psychosocial Approach to Erectile Dysfunction: Position Statements from the European Society of Sexual Medicine (ESSM) (2021) · cites this paper as [59]
Relationship conflicts are an important reason for lack of compliance or drop-out.
“In addition, therapy should identify and treat underlying relational dynamics because relationship conflicts are an important reason for lack of compliance or drop-out.59,99”
From A Psychosocial Approach to Erectile Dysfunction: Position Statements from the European Society of Sexual Medicine (ESSM) (2021) · cites this paper as [59]
Citations
Cites
Psychological and Interpersonal Dimensions of Sexual Function and Dysfunction
McCabe, M. P., Althof, S. E., Assalian, P., Chevret‐Méasson, M., Leiblum, S. R., Simonelli, C., & Wylie, K. R. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01618.x · Cited by 606
Fisher, W. A., Rosen, R. C., Eardley, I., Sand, M., & Goldstein, I. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00118.x · Cited by 335
Psychological and Interpersonal Dimensions of Sexual Function and Dysfunction
Althof, S. E., Leiblum, S. R., Chevret‐Méasson, M., Hartmann, U. H., Levine, S. B., McCabe, M. P., Plaut, M. S., Rodrigues, O. M., & Wylie, K. R. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00145.x · Cited by 250
A 4-year update on the safety of sildenafil citrate (Viagra®)
Padma-Nathan, H., Ian Eardley, C., Kloner, R. A., Laties, A. M., & Montorsi, F. (2002) · Urology · doi:10.1016/s0090-4295(02)01752-1 · Cited by 185
When an erection alone is not enough: biopsychosocial obstacles to lovemaking
Althof, S. E. (2002) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900799 · Cited by 184
British Society for Sexual Medicine Guidelines on the Management of Erectile Dysfunction
Hackett, G. I., Kell, P. D., Ralph, D. J., Dean, J. P., Price, D. E., Speakman, M. T., & Wylie, K. R. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.00773.x · Cited by 171
Fisher, W. A., Rosen, R. C., Mollen, M. D., Brock, G. B., KARLIN, G. S., Pommerville, P. J., Goldstein, I., Bangerter, K., Bandel, T.-J., Derogatis, L. R., et al. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00119.x · Cited by 148
ÇAYAN, S., BOZLU, M., CANPOLAT, B., & AKBAY, E. (2004) · Journal of Sex & Marital Therapy · doi:10.1080/00926230490465091 · Cited by 143
CLINICAL EFFICACY OF SILDENAFIL CITRATE BASED ON ETIOLOGY AND RESPONSE TO PRIOR TREATMENT
Jarow, J. P., Burnett, A. L. “., & Geringer, A. M. (1999) · The Journal of Urology · doi:10.1097/00005392-199909010-00024 · Cited by 143
LONG-TERM EFFICACY OF SILDENAFIL AND TACHYPHYLAXIS EFFECT
El-Galley, R., Rutland, H., Talic, R. F., Keane, T. E., & CLARK, H. (2001) · The Journal of Urology · doi:10.1016/s0022-5347(05)65866-1 · Cited by 113
CHEVRET, M., JAUDINOT, E., SULLIVAN, K., MARREL, A., & GENDRE, A. S. (2004) · Journal of Sex & Marital Therapy · doi:10.1080/00926230490262366 · Cited by 108
Compliance of sildenafil treatment for erectile dysfunction and factors affecting it
Jiann, B.-P., Yu, C.-C., Su, C.-C., & Tsai, J.-Y. (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901379 · Cited by 88
Why do so many people drop out from auto-injection therapy for impotence?
Althof, S. E., Turner, L. A., Levine, S. B., Risen, C., Kursh, E., Bodner, D., & Resnick, M. (1989) · Journal of Sex & Marital Therapy · doi:10.1080/00926238908403816 · Cited by 86
Why do patients with erectile dysfunction abandon effective therapy with sildenafil (Viagra)?
Klotz, T., Mathers, M., Klotz, R., & Sommer, F. (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901252 · Cited by 81
Incidence and determinants of sildenafil (dis)continuation: the Dutch cohort of sildenafil users
Souverein, P. C., Egberts, T. C. G., MEULEMAN, E. J. H., Urquhart, J., & Leufkens, H. G. M. (2002) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900883 · Cited by 79
Long-term follow-up of patients receiving injection therapy for erectile dysfunction
Sundaram, C. P., Thomas, W. J., Pryor, L. E., Sidi, A. A., Billups, K. L., & Pryor, J. L. (1997) · Urology · doi:10.1016/s0090-4295(97)00079-4 · Cited by 76
Althof, S. E., Turner, L. A., Levine, S. B., Bodner, D. R., Kursh, E. D., & Resnick, M. I. (1992) · The Journal of Urology · doi:10.1016/s0022-5347(17)37454-2 · Cited by 75
Reasons for discontinuation of sildenafil citrate after successful restoration of erectile function.
HwancheolSon, KwanjinPark, SooWoongKim, & Jae-SeungPaick (2004) · PubMed · Cited by 72
Althof, S. E., Turner, L. A., Levine, S. B., Risen, C. B., Kursh, E. D., Bodner, D. R., & Resnick, M. (1987) · Journal of Sex & Marital Therapy · doi:10.1080/00926238708403889 · Cited by 66
Conaglen, H. M., & Conaglen, J. V. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.00774.x · Cited by 54
Self-citationLjunggren, C., Hedelin, H. H., Salomonsson, K., & Ströberg, P. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2007.00688.x · Cited by 51
Predictors of Success and Risk Factors for Attrition in the Use of Intracavernous Injection
Gupta, R., Kirschen, J., Barrow, R. C. I., & Eid, J. F. (1997) · The Journal of Urology · doi:10.1016/s0022-5347(01)64834-1 · Cited by 50
Female partner perception of small-carrion implant
Kramarsky-Binkhorst, S. (1978) · Urology · doi:10.1016/0090-4295(78)90469-7 · Cited by 45
Giuliano, F., Montorsi, F., Mirone, V. G., Rossi, D., & Sweeney, M. L. (2000) · The Journal of Urology · doi:10.1016/s0022-5347(05)67286-2 · Cited by 44
Through the eyes of women: The partners’ perspective on tadalafil
Althof, S. E., Eid, J. F., Talley, D. R., Brock, G. B., Dunn, M. E., Tomlin, M. E., Natanegara, F., & Ahuja, S. (2006) · Urology · doi:10.1016/j.urology.2006.03.054 · Cited by 36
Althof, S. E., Turner, L. A., Levine, S. B., Risen, C. B., Bodner, D. R., Kursh, E. D., & Resnick, M. I. (1991) · Journal of Sex & Marital Therapy · doi:10.1080/00926239108404952 · Cited by 34
Mulhall, J. P., McLaughlin, T. P., Harnett, J., Scott, B., Burhani, S., & Russell, D. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00149.x · Cited by 34
The impact of erectile dysfunction on female partners: a qualitative investigation
Conaglen, H. M., & Conaglen, J. V. (2008) · Sexual & Relationship Therapy · doi:10.1080/14681990801918680 · Cited by 33
Self-citationHatzichristou, D. G., Haro, J. M., Martín‐Morales, A., Keitz, A. V., Riley, A. J., Bertsch, J., Belger, M. A., Wolka, A. M., Beardsworth, A., & for the EDOS Group (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01560.x · Cited by 30
Is Sex Only for the Healthy and Wealthy?
Ströberg, P., Hedelin, H. H., & Bergström, A. (2006) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2006.00233.x · Cited by 30
Al-Shaiji, T. F., & Brock, G. B. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209789206944 · Cited by 27
Sato, Y., Tanda, H., Kato, S., Onishi, S., Nitta, T., & Koroku, M. (2007) · International Journal of Urology · doi:10.1111/j.1442-2042.2007.01608.x · Cited by 25
Jiann, B.-P., Yu, C.-C., Tsai, J.-Y., Tt, W., Lee, Y.-H., & Huang, J.-K. (2003) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901047 · Cited by 25
The Impact of Oral ED Medication on Female Partners’ Relationship Satisfaction
McCabe, M. P., O’Connor, E. J., Conaglen, J. V., & Conaglen, H. M. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.02094.x · Cited by 16
Self-citationGiannitsas, K., Konstantinopoulos, A., Patsialas, C., & Perimenis, P. (2008) · PubMed Central · Cited by 8
Penile prosthesis implant: when, what and how
Bettocchi, C., Palumbo, F., Spilotros, M., Lucarelli, G. T., Ricapito, V. D., Palazzo, S., Battaglia, M., Selvaggi, F., & Ditonno, P. (2009) · Journal of Men s Health · doi:10.1016/j.jomh.2009.09.033 · Cited by 4
Edwards, C., & Briganti, A. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.661_4.x · Cited by 1
Fisher, W. A., Ian Eardley, C., McCabe, M. P., & Sand, M. (2008) · Sexologies · doi:10.1016/s1158-1360(08)72685-9 · Cited by 1
Flagged first, then by citations
1 of the 39 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Eardley, 2008, Associations between female partner attitudes and male-partner erectile dysfunction, treatment-seeking behaviour and treatment utilisation: Findings of the FEMALES study, J Sex Med, 5, 55
Cited by
Sorted by citations
Sexual dysfunction and infertility as late effects of cancer treatment
Schover, L. R., van der Kaaij, M. A. E., van Dorst, E. B. L., Creutzberg, C. L., Huyghe, É., & Kiserud, C. E. (2014) · European Journal of Cancer Supplements · doi:10.1016/j.ejcsup.2014.03.004 · Cited by 234
PDE5 inhibitors: considerations for preference and long-term adherence
Smith, W. B., McCaslin, I., Gökçe, A., Mandava, S. H., Trost, L. W., & Hellstrom, W. J. G. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12074 · Cited by 120
Seftel, A. D., de la Rosette, J. J. M. C. H., Birt, J. A., Porter, V., Zarotsky, V., & Viktrup, L. (2012) · International Journal of Clinical Practice · doi:10.1111/ijcp.12044 · Cited by 105
Corona, G., Rastrelli, G., Burri, A. V., Serra, E., Gianfrilli, D., Mannucci, E., Jannini, E. A., & Maggi, M. (2016) · Andrology · doi:10.1111/andr.12255 · Cited by 97
Dewitte, M., Bettocchi, C., Carvalho, J., Corona, G., Flink, I., Limoncin, E., Pascoal, P., Reisman, Y., & Van Lankveld, J. (2021) · Sexual Medicine · doi:10.1016/j.esxm.2021.100434 · Cited by 97
“In addition, therapy should identify and treat underlying relational dynamics because relationship conflicts are an important reason for lack of compliance or drop-out.(59,99)”
BackgroundWhich Is First? The Controversial Issue of Precedence in the Treatment of Male Sexual Dysfunctions
Jannini, E. A., Isidori, A. M., Aversa, A., Lenzi, A., & Althof, S. E. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12315 · Cited by 72
The role of the sexual partner in managing erectile dysfunction
Li, H., Gao, T., & Wang, R. (2016) · Nature Reviews Urology · doi:10.1038/nrurol.2015.315 · Cited by 65
Kim, S., Lee, Y.-S., Seo, K.-K., Jung, G.-W., & Kim, T. (2013) · International Journal of Impotence Research · doi:10.1038/ijir.2013.41 · Cited by 51
The 2018 Revision to the Process of Care Model for Management of Erectile Dysfunction
Mulhall, J. P., Giraldi, A. G. E., Hackett, G. I., Hellstrom, W. J. G., Jannini, E. A., Aurioles, E. R., Trost, L. W., & Hassan, T. A. (2018) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2018.05.021 · Cited by 43
Men's experiences of sexuality after cancer: a material discursive intra-psychic approach
Gilbert, E., Ussher, J. M., Perz, J., Wong, W. K. T., Hobbs, K., & Mason, C. (2013) · Culture Health & Sexuality · doi:10.1080/13691058.2013.789129 · Cited by 38
Carvalheira, A. A., Forjaz, V., & Pereira, N. M. (2014) · Sexual Medicine · doi:10.1002/sm2.31 · Cited by 22
Eroticization as a factor influencing erectile dysfunction treatment effectiveness
Kukula, K. C., Jackowich, R. A., & Wassersug, R. J. (2013) · International Journal of Impotence Research · doi:10.1038/ijir.2013.29 · Cited by 20
Liu, W., Antonelli, P. J., Dahm, P., Gerhard, T., Delaney, J. A., Segal, R., Crystal, S., & Winterstein, A. G. (2018) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.4405 · Cited by 16
Williams, P. R., McBain, H. B., Amirova, A., Newman, S. P., & Mulligan, K. (2020) · International Journal of Impotence Research · doi:10.1038/s41443-020-0249-1 · Cited by 16
Huang, S.-T., & Jiann, B.-P. (2013) · International Journal of Impotence Research · doi:10.1038/ijir.2013.8 · Cited by 14
Integrative Approaches to the Treatment of Erectile Dysfunction
Berry, M. D., & Berry, P. D. (2014) · Current Sexual Health Reports · doi:10.1007/s11930-014-0012-z · Cited by 11
McGraw, S. A., Rosen, R. C., Althof, S. E., Dunn, M., Cameron, A., & Wong, D. (2015) · Journal of Sex & Marital Therapy · doi:10.1080/0092623x.2013.864368 · Cited by 10
Shindel, A. W. (2012) · Yearbook of Urology · doi:10.1016/j.yuro.2012.05.060 · Cited by 8
Considerations for prescribing pharmacotherapy for the treatment of erectile dysfunction
Bakr, A. M., El‐Sakka, A. A., & El‐Sakka, A. I. (2020) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2020.1851365 · Cited by 7
Gruenwald, I., Spector, A., Shultz, T., Lischinsky, D., & Kimmel, E. (2019) · International Journal of Impotence Research · doi:10.1038/s41443-019-0142-y · Cited by 6
Brock, G. B., Hellstrom, W. J. G., Giraldi, A. G. E., & Honig, S. C. (2025) · Sexual Medicine · doi:10.1093/sexmed/qfaf021 · Cited by 3
Aurioles, E. R., El-Meliegy, A., Abdulwahed, S., Henneges, C., Sorsaburu, S., & Gurbuz, S. (2014) · Current Medical Research and Opinion · doi:10.1185/03007995.2014.946125 · Cited by 3
Avanafil: The Second-Generation Treatment of Erectile Dysfunction
Corona, G., Maggi, M., & Jannini, E. A. (2016) · European Medical Journal · doi:10.33590/emj/10314434 · Cited by 3
Le couple : une entité incontournable ?
Cour, F., Corman, A., & Costa, P. (2013) · The French Journal of Urology · doi:10.1016/j.purol.2012.11.005 · Cited by 2
Louizos, C. C., & Knight, P. K. (2015) · Pharmacy · doi:10.3390/pharmacy3040295 · Cited by 2
Why stop a good thing? Discontinuing PDE5 inhibitors
Conaglen, H. M., & Conaglen, J. V. (2012) · Nature Reviews Urology · doi:10.1038/nrurol.2012.165 · Cited by 1
Self-citationBaydaroglu, E., Eschwège, P., Hubert, J., & Osta, R. E. (2019) · The French Journal of Urology · doi:10.1016/j.purol.2019.04.007 · Cited by 1
Predictors of Patient Willingness to Consider Surgery Prior to Consultation at Sexual Health Clinic
Bole, R., Ziegelmann, M. J., Gopalakrishna, A., Collins, C. S., Alom, M., Trost, L. W., Helo, S., & Köhler, T. (2020) · Urology · doi:10.1016/j.urology.2020.09.002 · Cited by 1
Erectile dysfunction and EDMs: results of an Italian research in a public hospital
Gambino, G., Gentile, V., Silvaggi, C., Tripodi, F. B., Pierleoni, L., Cosmi, V. D., Giuliani, M., & Simonelli, C. (2012) · F1000Research · doi:10.7490/f1000research.1092698.1
Tratamiento sexológico de las disfunciones eréctiles
Bonierbale, M., & Colson, M.-H. (2013) · EMC - Urología · doi:10.1016/s1761-3310(13)65467-5
Prise en charge sexologique des dysfonctions érectiles
Bonierbale, M., & Colson, M.-H. (2013) · Annales d Urologie · doi:10.1016/s1762-0953(13)30746-8
Author reply: The nuances of GRADE
Domes, T., Najafabadi, B. T., Roberts, M. T., Campbell, J., Flannigan, R. K., Bach, P. V., Patel, P., Langille, G. M., Krakowsky, Y., & Violette, P. D. (2021) · Canadian Urological Association Journal · doi:10.5489/cuaj.7679
Savira, M., Birowo, P., Rasyid, N., Chung, E., & Atmoko, W. (2026) · Asian Journal of Andrology · doi:10.4103/aja202588
Management of Erectile Dysfunction and the Pharmacist's Role
Gauld, N. J., & Braund, R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-26472-6.00215-1
Metadata
- Authors
- Conaglen, H. M., & Conaglen, J. V.
- Affiliations
- University of Auckland (NZ)
- Corresponding author
- Conaglen, Helen M.
- Venue
- The Journal of Sexual Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-03-01
- Volume
- 9
- Issue
- 3
- Pages
- 857-865
- ISSN
- 1743-6095 (ISSN-L)
- 1743-6109
- OpenAlex
- W2118017716
- Cited by
- 34
- References
- 39
- Citations by year
- 2026: 2 · 2025: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2016: 3 · 2015: 1 · 2014: 4 · 2013: 10 · 2012: 4
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- The Journal of Sexual Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
- Keywords
- erectile dysfunction, phosphodiesterase-5 inhibitors, medication adherence, treatment discontinuation, couples, reasons for discontinuation, cost barriers, partner communication, sexual activity
- MeSH terms
- Aged, Female, Follow-Up Studies, Humans, Erectile Dysfunction, Male, Middle Aged, Patient Compliance, Personal Satisfaction, Sexual Partners, Phosphodiesterase 5 Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review