CoChat
Sign Up
Cited by 27Coffee research and impactsCarcinogens and Genotoxicity AssessmentPlant Toxicity and Pharmacological Properties

The DOI matches its Crossref record; 250 of the 250 references it cites were found in a registry or an index.

THE PHARMACOLOGY AND TOXICOLOGY OF CAFFEINE

LACHANCE, MICHAEL P.·1982·Journal of Food Safety
DOI 10.1111/j.1745-4565.1982.tb00435.x
Open this paper in CoChat — free account

Abstract

The widespread use of caffeine is most commonly linked to the stimulatory action it has on the central nervous system. Generally, adverse effects include gastrorrhea, insomnia, and diuresis. Tolerance and withdrawal symptoms have been observed and excessive consumption can lead to an anxiety neurosis condition (caffeinism). The actions of caffeine may involve its effects on neurotransmitter turnover and metabolism; its promotion of the cellular messenger, cAMP; its sensitization of the calcium releasing mechanisms of cellular reticulum; or its antagonism of the autacoid, adenosine. Caffeine lethality is rare in man but caffeine poisoning with its gastrointestinal, CNS, and cardiovascular stimulation could especially be hazardous to children. Most of the mutagenicity work has been performed in organisms whose cellular DNA synthesis and repair mechanism vary significantly from those found in man. The work in human cell lines suggests that caffeine‐induced chromosomal breakage, with its lack of chromatid exchange would promote cell lethality, not muta‐genticity. Nothing but circumstantial evidence implicates caffeine as a human carcinogen or teratogen. Involvement of caffeine as a cocarcinogen or a coteratogen (which includes effects on gamete production or fetal development) appears far more likely, but neither has even begun to be truly evaluated. Basic metabolism of caffeine involves the processes of N‐demethylation, hydration, and oxidation; and most likely requires the cytochrome P1‐450 system. Though various metabolites of caffeine are pharmacologically active, the extent of involvement of individual metabolites in the pharmacological or toxicological responses of caffeine in man is still unknown.

Overview

Integrity signals

Registry

Crossref · 10.1111/j.1745-4565.1982.tb00435.x

Cites

250 of 250 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 250 references

Research works printed but not linked: 58

  1. ABOU‐ISSA H., 1982, In vitro and in vivo effects of caffeine on cyclic nucleotide metabolism in mammary tissue, Fed. Proc, 40, 665
  2. ALDRIDGE A., 1978, Caffeine metabolism in the developing human infant, Pharmacologist, 20, 263
  3. ARANDA J., 1979, Metabolism of theophylline to caffeine in human fetal liver organ cultures, Pediatr. Res, 13, 366
  4. ARANDA J., 1979, Effect of caffeine on control of ventilation in premature infants with apnea, Pediatr. Res, 13, 366
  5. ARNAUD M. J., 1980, Quantitative analysis of theophylline metabolites by hplc, after oral or iv administration, Experientia, 36, 704
  6. BAER H. P., 1978, Physiological and Regulatory Function of Adenosine and Adenine Nucleotides, (various authors)
  7. BERTRAND M., 1970, Ectrodactylie provoquee par la caffeine chez les rongeurs; role des facturs specifiques, C. R. Soc. Biol, 164, 1488
  8. BESSON H., 1964, Potentialisation des effets convulsivants et de la toxicite de l'isoniazide par la theophylline et la caffeine, Ann. Pharm. Fr, 22, 345
  9. BORLEE L, 1978, Le cafe, facteur de risque pendat la grossesse?, Louvain Med, 97, 279
  10. BURG A., 1977, Testimony presented before the Select Committee on GRAS Substances at a public hearing on caffeine, September 26
  11. CASIER M. I., 1959, Aumento della tossicita della caffeina e della sua concentrazione a livello encefalico indotto dal meprobamato, nel mus musculus indagine farmacologica e radiochimica, Arch. Int. Pharmacodyn. Ther, 122, 463
  12. COHEN M. H., 1975, Enhancement of the antitumor effect of 1,3‐bis(2‐chloroethy)‐1‐nitrosourea by various psychotropic drugs in combination with caffeine, J. Pharmacol. Exp. Ther, 194, 425
  13. COLLINS T. F. X., 1982, A comprehensive study of the teratogenic potential of caffeine in rats when given by oral intubation, J. Environ. Pathol. Toxicol
  14. CUZZONE H., 1982, Caffeine effects on 5‐HT uptake and release in rat cerebral cortex and midbrain raphe region, Fed. Proc, 40, 266
  15. DESCOTES J., 1979, Influence de la consommation de tabac sur la pharmacocinetique de la cafeine, Therapie, 34, 619
  16. DREISBACH R., 1943, Caffeine‐withdrawal headache, J. Lab. Clin. Med, 28, 1212
  17. FOLTZ E., 1942, The influence of amphetamine (benzedrine) sulfate, d‐desoxyephedrine hydrochloride (pervitin), and caffeine upon work output and recovery when rapidly exhausting work is done by trained subjects, J. Lab. Clin. Med, 28, 603
  18. GARCIA E., 1982, The effects of a plant fiber mix on caffeine toxicity in weanling rats, Fed. Proc, 40, 846
  19. GOLDMAN H. D., 1979, The kinetics of expired 14CO2 derived from the N‐demethylation of caffeine in rats as a measure of hepatic cytochrome P‐448 drug metabolism activity, Pharmacologist, 21, 206
  20. GOLDSTEIN A., 1965, Psychotropic effects of caffeine in man I., Individual differences in sensitivity to caffeine-induced wakefulness. J. Pharmacol. Exp. Ther, 149, 156
  21. GOLDSTEIN A., 1965, Psychotropic effects of caffeine in manII., Alertness, psychomotor coordination, and mood, J. Pharmacol. Exp. Ther, 150, 146
  22. GOLDSTEIN A., 1969, Psychotropic effects of caffeine in man, IV. Quantitative and qualitative differences associated with habituation to coffee. Clin. Pharmacol. Ther, 10, 489
  23. GOTH A., 1978, Medical Pharmacology, 271
  24. HERZ R., 1965, Caffeine inhibition of Ca uptake by muscle reticulum, Fed. Proc, 24, 208
  25. HIRSH K. R., 1974, Spontaneous locomotor activity changes evoked by caffeine in mice, Fed. Proc, 33, 466
  26. HIRSH K. R., 1974, Caffeine effects on spontaneous activity of reticular formation neurons, Neurosci. Abst, 1, 257
  27. HOLLINGWORTH H. L., 1912, The influence of caffeine on mental and motor efficiency, Ther. Gaz, 36, 1
  28. HORNING M., 1973, Fetal Pharmacology, 265
  29. JACOBSON M. F., 1982, Letter: Coffee and birth defects, Lancet, 1, 1415
  30. KAUL L., 1982, Relationship of caffeine and ethy‐nylestradiol (EE2) to hypertension in rats, Fed. Proc, 40, 930
  31. LSRO, (Life Science Research Office)., 1978, Evaluation of the Health Aspects of Caffeine as a Food Ingredient, 81
  32. MAKLER A., 1980, Factors affecting sperm motility, IV. Incubation of human semen with caffeine, kallikrein and other metabolically active compounds. Fertil. Steril, 33, 624
  33. MAREN T. H., 1961, The additive renal effect of oral aminophylline and trichlormethiazide in man, Clin. Res, 9, 57
  34. MAU G., 1974, Kaffee‐und alkoholkonsum‐risiko‐faktoren in der schwangerschaft? Geburtsh, U. Frauenheilk, 34, 1018
  35. MERRILL G., 1982, Adrenergic coronary constriction and adenosine coronary dilation: the effects of respiratory hyper‐ and hypocapnia, Fed. Proc, 40, 706
  36. MILLER J., 1970, Carcinogenesis by chemicals: an overview, Cancer Res, 30, 559
  37. MITZNEGG P., 1971, The effect of ageing, caffeine-treatment, and ionizing-radiation on nucleic acid synthesis in the mouse liver life Sci, 1011, 1281
  38. NAGNIBEDA N., 1978, Caffeine effect on catecholamine content in perfusate of rabbit superior cervical ganglion and cat ciliar ganglion, Fiziol. Z. H, 24, 220
  39. NETTER K. J., 1975, Basic and Therapeutic Aspects of Perinatal Pharmacology, 39
  40. NICHOLS R. E., 1963, Antagonism of the vasopressor effect of ATP by caffeine, Fed. Proc, 22, 308
  41. PARSONS W., 1976, Stimulation of caffeine metbolism in the rat by 3‐methylcholanthrene, Fed. Proc, 35, 665
  42. POWERS H., 1925, The syndrome of coffee, Med. J. Rec, 121, 745
  43. PROKOP V. L., 1964, Die Beeinflussung der adrenalinwirkung durch koffein, Med. Klin, 59, 2016
  44. RITCHIE J., 1975, The Phamcological Basis of Therapeutics, 367
  45. ROSS V. C., 1982, Effects of acute oral caffeine treatment on spleen and thymus of male rats, Fed. Proc, 40, 738
  46. SKALKO R., 1982, The toxicology of chemical interactions during pregnancy in mice: caffeine and dilantin, The Toxicologist, 1, 31
  47. SLIZYNSKI B., 1971, Immediate effects of chemicals on mouse chromosome: I caffeine, Curr. Mod. Biol, 3, 285
  48. SOBOTKA T., 1979, Neurobehavioral teratology of caffeine exposure in rats, Neurotoxicology, 1, 403
  49. SOMMER K., 1975, Identification and quantification of drugs in human amniotic fluid, Res. Commun. Chem. Pathol. Pharmacol, 12, 583
  50. SPECTOR W. S., 1956, Handbook of Toxicology, 56
  51. U. S. BUREAU OF THE CENSUS, FOEIGN TRADE DIVISION., 1975, U. S. Imports for Consumption and General Imports. FT 246
  52. WALTHER H., 1962, Zur coffein und theophyllinwirkung am ermudeten rat‐tenywerchfellpraparat, Arch. Int. Pharmacodyn. Ther, 138, 597
  53. WARSZAWSKI D., 1980, Caffeine metabolism in liver slices of young and adult rats, Isr. J. Med. Sci, 16, 618
  54. WOOD H. C., 1912, The effects of caffeine on the circulatory and muscular systems, Ther. Gaz, 36, 6
  55. WRAGG J., 1967, Inhibition of DNA polymerase activity by caffeine in a mammalian cell line, J. Cell Biol, 35, 146A
  56. ZAJDELA F., 1973, Effet inhibiteur de la cafeine sur l'induction de cancers cutanes par les rayons ultraviolets chez la souris, C. R. Acad. Sci, 277, 1073
  57. ZAJDELA F., 1978, International Conference on Ultraviolet Carcinogenesis, National Cancer Institute Monograph 50, 130
  58. ZHESTYANIKOV V., 1974, The mechanisms of inhibition of the postirradiation recovery in cellsII., Inhibition of the unscheduled DNA synthesis in hela cells after UV-irradiation by caffeine and acriflavine. Tsitologiya, 16, 868

Cited by

Sorted by citations

See all 27

Related

Metadata

Authors
LACHANCE, M. P.
Affiliations
University of Louisville (US)
Corresponding author
LACHANCE, MICHAEL P.
Venue
Journal of Food Safety
Publisher
Wiley
Published
1982-06
Volume
4
Issue
2
Pages
71-112
ISSN
  • 0149-6085 (ISSN-L)
  • 1745-4565
DOI
10.1111/j.1745-4565.1982.tb00435.x
OpenAlex
W2058152412
Cited by
27
References
250
Citations by year
2022: 1 · 2021: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2012: 1
FWCI
3.46
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 9072 d)
Locations
Journal of Food Safety (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Plant Toxicity and Pharmacological Properties
Keywords
caffeine, caffeine toxicity, caffeine pharmacology, central nervous system stimulation, caffeine withdrawal, adenosine antagonism, cyclic AMP, chromosomal damage, carcinogenesis, teratogenicity, caffeine metabolism, cytochrome P450, caffeine metabolites

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review