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Cited by 27Coffee research and impactsCarcinogens and Genotoxicity AssessmentPlant Toxicity and Pharmacological Properties

The DOI matches its Crossref record; 250 of the 250 references it cites were found in a registry or an index.

THE PHARMACOLOGY AND TOXICOLOGY OF CAFFEINE

LACHANCE, MICHAEL P.·1982·Journal of Food Safety
DOI 10.1111/j.1745-4565.1982.tb00435.x
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Abstract

The widespread use of caffeine is most commonly linked to the stimulatory action it has on the central nervous system. Generally, adverse effects include gastrorrhea, insomnia, and diuresis. Tolerance and withdrawal symptoms have been observed and excessive consumption can lead to an anxiety neurosis condition (caffeinism). The actions of caffeine may involve its effects on neurotransmitter turnover and metabolism; its promotion of the cellular messenger, cAMP; its sensitization of the calcium releasing mechanisms of cellular reticulum; or its antagonism of the autacoid, adenosine. Caffeine lethality is rare in man but caffeine poisoning with its gastrointestinal, CNS, and cardiovascular stimulation could especially be hazardous to children. Most of the mutagenicity work has been performed in organisms whose cellular DNA synthesis and repair mechanism vary significantly from those found in man. The work in human cell lines suggests that caffeine‐induced chromosomal breakage, with its lack of chromatid exchange would promote cell lethality, not muta‐genticity. Nothing but circumstantial evidence implicates caffeine as a human carcinogen or teratogen. Involvement of caffeine as a cocarcinogen or a coteratogen (which includes effects on gamete production or fetal development) appears far more likely, but neither has even begun to be truly evaluated. Basic metabolism of caffeine involves the processes of N‐demethylation, hydration, and oxidation; and most likely requires the cytochrome P1‐450 system. Though various metabolites of caffeine are pharmacologically active, the extent of involvement of individual metabolites in the pharmacological or toxicological responses of caffeine in man is still unknown.

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Metadata

Authors
LACHANCE, M. P.
Affiliations
University of Louisville (US)
Corresponding author
LACHANCE, MICHAEL P.
Venue
Journal of Food Safety
Publisher
Wiley
Published
1982-06
Volume
4
Issue
2
Pages
71-112
ISSN
  • 0149-6085 (ISSN-L)
  • 1745-4565
DOI
10.1111/j.1745-4565.1982.tb00435.x
OpenAlex
W2058152412
Cited by
27
References
250
Citations by year
2022: 1 · 2021: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2012: 1
FWCI
3.46
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 9072 d)
Locations
Journal of Food Safety (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Plant Toxicity and Pharmacological Properties
Keywords
caffeine, caffeine toxicity, caffeine pharmacology, central nervous system stimulation, caffeine withdrawal, adenosine antagonism, cyclic AMP, chromosomal damage, carcinogenesis, teratogenicity, caffeine metabolism, cytochrome P450, caffeine metabolites

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