Catecholamines and Pancreatic Hormones during Autonomic Blockade in Exercising Man
Abstract
The importance of autonomic nervous activity for the pancreatic hormonal response to exercise in man was studied. 7 men ran at 58% of V̇o 2 max (determined without administration of drugs) to exhaustion during a‐adrenergic blockade with phentolamine (P), during parasympathetic blockade with atropine (A), or without drugs (C). At rest phentolamine increased the plasma concentrations of both insulin and norepinephrine. During exercise norepinephrine concentrations increased and were in P experiments 3 times the concentrations in C experiments. Insulin always declined during exercise but in P experiments never decreased below basal levels. At identical times neither glucagon nor glucose differed significantly in the different expts. Thus during exercise α‐adrenergic blockade increased insulin concentrations but did not diminish the glucagon response. Nor was this response increased when β‐receptor stimulation in P experiments was intensified by the particularly high catecholamine concentrations. The concentrations of FFA, glycerol and lactate were highest in P experiments and identical in A and C experiments. These findings indicate that during prolonged moderate exercise in man insulin secretion is depressed by stimulation of α‐adrenergic receptors whereas glucagon secretion is not influenced by adrenergic receptors. Stimulation of β‐adrenergic receptors enhances lipolysis but neither lipolysis nor pancreatic hormonal secretion is influenced by cholinergic activity during exercise.
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The ergogenic effects of caffeine have been attributed to antagonism of receptors in the upper gastrointestinal tract facilitating a central modulation of motor unit activity and adenosine receptor stimulation.
“the ergogenic effects of caffeine have also been attributed to the antagonism of receptors in the upper gastrointestinal tract facilitating a central modulation of motor unit activity and adenosine receptor stimulation 74 .”
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- Authors
- Galbo, H., Christensen, N. J., & Holst, J. J.
- Affiliations
- University of Copenhagen (DK)
- Venue
- Acta Physiologica Scandinavica
- Publisher
- Wiley
- Published
- 1977-12
- Volume
- 101
- Issue
- 4
- Pages
- 428-437
- ISSN
- 0001-6772 (ISSN-L)
- 1365-201X
- OpenAlex
- W2057383257
- Cited by
- 81
- References
- 21
- Citations by year
- 2025: 1 · 2022: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1
- FWCI
- 11.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Physiologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- autonomic nervous system, physical activity, insulin secretion, glucagon secretion, norepinephrine, catecholamines, alpha-adrenergic blockade, phentolamine, parasympathetic blockade, atropine, beta-adrenergic receptors, lipolysis, free fatty acids, glycerol, lactate, cholinergic activity
- MeSH terms
- Adult, Atropine, Autonomic Nervous System, Blood Glucose, Catecholamines, Epinephrine, Physical Exertion, Fatty Acids, Nonesterified, Glucagon, Humans, Insulin, Lactates, Male, Norepinephrine, Pancreatic Hormones, Phentolamine, Receptors, Adrenergic
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