Epigenetic Control of Skeletal Muscle Fibre Type
Abstract
Adult muscle is extremely plastic. However, the muscle precursor cells associated with those fibres show stable and heritable differences in gene expression indicative of epigenetic imprinting. Epigenetic processes in the development of skeletal muscle have been appreciated for over a decade; however, there are a paucity of studies looking at whether epigenetics determines the phenotype of adult and/or ageing skeletal muscle. This review presents the evidence that epigenetics plays a role in determining adult muscle function and a series of unanswered questions that would greatly increase our understanding of how epigenetics works in adult muscle. With the increased interest in epigenetics, over the next few years this field will begin to unfold in unimaginable directions.
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Epigenetic modifications are believed to control muscle fiber type and can be influenced by external factors such as nutrition.
“Epigenetic modifications are believed to control muscle fiber type, and can be influenced by external factors such as nutrition [153].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [153]
Cites
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“This new definition is designed to combine the classic idea of a heritable change in gene expression in the absence of changes to the sequence of the genome (Reik 2007) with the more transient changes in chromosomal structure that occur during acute transcriptional activation and repression (Clayton et al.”
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Mitochondria, Muscle Health, and Exercise with Advancing Age
Carter, H. N., Chen, C. C. W., & Hood, D. A. (2015) · Physiology · doi:10.1152/physiol.00039.2014 · Cited by 191 · see citing works
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“Epigenetic modifications are believed to control muscle fiber type, and can be influenced by external factors such as nutrition [153].”
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- Authors
- Baar, K.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Baar, K.
- Venue
- Acta Physiologica
- Publisher
- Wiley
- Published
- 2010-07
- Volume
- 199
- Issue
- 4
- Pages
- 477-487
- ISSN
- 1748-1708 (ISSN-L)
- 1748-1716
- OpenAlex
- W1855757370
- Cited by
- 57
- References
- 5
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 8 · 2012: 6
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Physiologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- epigenetics, skeletal muscle fiber types, epigenetic imprinting, muscle precursor cells, myogenesis, muscle plasticity
- MeSH terms
- Acetylation, Aging, Animals, Histones, Humans, Mitochondria, Phenotype, Gene Expression, Muscle, Skeletal, Muscle Fibers, Skeletal, DNA Methylation, Chromatin Assembly and Disassembly, Epigenesis, Genetic
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