Histone modifications and exercise adaptations

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The Role of Chromatin during Transcription

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Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes

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Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

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Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis

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Cotranscriptional Set2 Methylation of Histone H3 Lysine 36 Recruits a Repressive Rpd3 Complex

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Enzymatic Activity Associated with Class II HDACs Is Dependent on a Multiprotein Complex Containing HDAC3 and SMRT/N-CoR

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Histone Deacetylases 5 and 9 Govern Responsiveness of the Heart to a Subset of Stress Signals and Play Redundant Roles in Heart Development

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Chromatin remodelling: the industrial revolution of DNA around histones

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Regulation of Skeletal Myogenesis by Association of the MEF2 Transcription Factor with Class II Histone Deacetylases

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AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5

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Histone Deacetylase 7 Maintains Vascular Integrity by Repressing Matrix Metalloproteinase 10

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The logic of chromatin architecture and remodelling at promoters

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Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5

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Histone deacetylase degradation andMEF2 activation promote the formation of slow-twitch myofibers

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Control of muscle development by dueling HATs and HDACs

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Snf1--a Histone Kinase That Works in Concert with the Histone Acetyltransferase Gcn5 to Regulate Transcription

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Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

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Exercise-induced histone modifications in human skeletal muscle

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SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes

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Exercise and Myocyte Enhancer Factor 2 Regulation in Human Skeletal Muscle

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Myocyte Enhancer Factor 2 (MEF2)-Binding Site Is Required forGLUT4 Gene Expression in Transgenic Mice

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The Histone Deacetylase HDAC4 Connects Neural Activity to Muscle Transcriptional Reprogramming

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Histone Deacetylase 5 Acquires Calcium/Calmodulin-Dependent Kinase II Responsiveness by Oligomerization with Histone Deacetylase 4

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Exercise Increases Ca2+–Calmodulin‐Dependent Protein Kinase II Activity in Human Skeletal Muscle

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Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression

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Exercise Increases Nuclear AMPK α2 in Human Skeletal Muscle

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Effects of exercise on GLUT-4 and glycogenin gene expression in human skeletal muscle

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Activity-dependent and -independent nuclear fluxes of HDAC4 mediated by different kinases in adult skeletal muscle

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CaMK activation during exercise is required for histone hyperacetylation and MEF2A binding at the MEF2 site on the<i>Glut4</i>gene

Smith, J. A. H., Kohn, T. A., Chetty, A. K., & Ojuka, E. O. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00747.2007 · Cited by 115 · see citing works

An expression screen reveals modulators of class II histone deacetylase phosphorylation

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Protein Kinase D1 Stimulates MEF2 Activity in Skeletal Muscle and Enhances Muscle Performance

Kim, M.-S., Fielitz, J., McAnally, J., Shelton, J. M., Lemon, D. D., McKinsey, T. A., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00189-08 · Cited by 102 · see citing works

Exercise increases MEF2‐ and GEF DNA‐binding activities in human skeletal muscle

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The deacetylase HDAC4 controls myocyte enhancing factor‐2‐dependent structural gene expression in response to neural activity

Cohen, T. J., Barrientos, T., Hartman, Z. C., Garvey, S. M., Cox, G. A., & Yao, T. (2008) · The FASEB Journal · doi:10.1096/fj.08-115931 · Cited by 86 · see citing works

Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading

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Caffeine induces hyperacetylation of histones at the MEF2 site on theGlut4promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism

Mukwevho, E., Kohn, T. A., Lang, D. M., Nyatia, E., Smith, J. A. H., & Ojuka, E. O. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00312.2007 · Cited by 75 · see citing works

Effect of fill-pulse parameters on deep-level transient spectroscopy peaks in highly doped p-type InP

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Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 Myoblasts

Takemori, H., HASHIMOTO, Y. K., Nakae, J., Olson, E. N., & Okamoto, M. (2009) · Endocrine Journal · doi:10.1507/endocrj.k08e-173 · Cited by 66 · see citing works

Epigenetic Control of Skeletal Muscle Fibre Type

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Parallel mechanisms for resting nucleo-cytoplasmic shuttling and activity dependent translocation provide dual control of transcriptional regulators HDAC and NFAT in skeletal muscle fiber type plasticity

Shen, T., Liu, Y., Randall, W. R., & Schneider, M. F. (2006) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-006-9080-7 · Cited by 46 · see citing works

Heterochromatin dysregulation in human diseases

Hahn, M., Dambacher, S., & Schotta, G. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00053.2010 · Cited by 44 · see citing works

Integrative Biology of Exercise

Hawley, J. A., Hargreaves, M., Joyner, M. J., & Zierath, J. R. (2014) · Cell · doi:10.1016/j.cell.2014.10.029 · Cited by 1,152 · see citing works

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Milagro, F. I., Mansego, M. L., de Miguel, C., & Martínez, J. A. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.06.010 · Cited by 310 · see citing works

Molecular Responses to Acute Exercise and Their Relevance for Adaptations in Skeletal Muscle to Exercise Training

Egan, B., & Sharples, A. P. (2023) · Physiological Reviews · doi:10.1152/physrev.00054.2021 · Cited by 278 · see citing works

Nutrition, Epigenetics, and Metabolic Syndrome

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New strategies in sport nutrition to increase exercise performance

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The effects of obesity on skeletal muscle contractile function

Tallis, J. A., James, R. S., & Seebacher, F. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.163840 · Cited by 214 · see citing works

Physical activity in the prevention of human diseases: role of epigenetic modifications

Grazioli, E., Dimauro, I., Mercatelli, N., Wang, G., Pitsiladis, Y. P., Luigi, L. D., & Caporossi, D. (2017) · BMC Genomics · doi:10.1186/s12864-017-4193-5 · Cited by 191 · see citing works

Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis

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Physical exercise and epigenetic modifications in skeletal muscle

Widmann, M., Nieß, A. M., & Munz, B. (2019) · Sports Medicine · doi:10.1007/s40279-019-01070-4 · Cited by 165 · see citing works

Exercise: Putting Action into Our Epigenome

Denham, J., Marques, F. Z., O’Brien, B. J., & Charchar, F. J. (2013) · Sports Medicine · doi:10.1007/s40279-013-0114-1 · Cited by 142 · see citing works

Epigenetic changes in healthy human skeletal muscle following exercise– a systematic review

Jacques, M., Hiam, D., Craig, J. M., Barrès, R., Eynon, N., & Voisin, S. A. C. (2019) · Epigenetics · doi:10.1080/15592294.2019.1614416 · Cited by 137 · see citing works

Epigenetic regulation on gene expression induced by physical exercise.

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Expanding roles for AMPK in skeletal muscle plasticity

Mounier, R., Théret, M., Lantier, L., Foretz, M., & Viollet, B. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.02.009 · Cited by 130 · see citing works

Heat Acclimation, Epigenetics, and Cytoprotection Memory

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Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice

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Epigenetics and cytoprotection with heat acclimation

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Effect of different exercise protocols on histone acetyltransferases and histone deacetylases activities in rat hippocampus

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Telomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training

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Physical Exercise as an Epigenetic Modulator

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Resistance to Aerobic Exercise Training Causes Metabolic Dysfunction and Reveals Novel Exercise-Regulated Signaling Networks

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Physical Exercise and Epigenetic Modulation: Elucidating Intricate Mechanisms

Pareja-Galeano, H., Sanchis‐Gomar, F., & García‐Giménez, J. L. (2014) · Sports Medicine · doi:10.1007/s40279-013-0138-6 · Cited by 84 · see citing works

The Corepressor NCoR1 Antagonizes PGC-1 <i>α</i> and Estrogen-Related Receptor <i>α</i> in the Regulation of Skeletal Muscle Function and Oxidative Metabolism

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Genetic and epigenetic sex-specific adaptations to endurance exercise

Landen, S., Voisin, S., Craig, J. M., McGee, S. L., Lamon, S., & Eynon, N. (2019) · Epigenetics · doi:10.1080/15592294.2019.1603961 · Cited by 76 · see citing works

A brief review of exercise, bipolar disorder, and mechanistic pathways

Thomson, D., Turner, A., Lauder, S., Gigler, M. E., Berk, L., Singh, A., Pasco, J. A., Berk, M., & Sylvia, L. G. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00147 · Cited by 79 · see citing works

Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder

Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/7014146 · Cited by 65 · see citing works

Exercise and the control of muscle mass in human

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Dynamic enhancers control skeletal muscle identity and reprogramming

Ramachandran, K., Senagolage, M. D., Sommars, M. A., Futtner, C. R., Omura, Y., Allred, A. L., & Barish, G. D. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000467 · Cited by 59 · see citing works

The Therapeutic Effects of Treadmill Exercise on Osteoarthritis in Rats by Inhibiting the HDAC3/NF-KappaB Pathway in vivo and in vitro

Zhang, H., Ji, L., Yang, Y., Wei, Y., Zhang, X., Gang, Y., Lu, J., & Bai, L. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01060 · Cited by 58 · see citing works

Cell environment shapes TDP-43 function with implications in neuronal and muscle disease

Šušnjar, U., Škrabar, N., Brown, A., Abbassi, Y., Phatnani, H. P., Phatnani, H. P., Fratta, P., Kwan, J. Y., Sareen, D., Broach, J. R., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03253-8 · Cited by 54 · see citing works

Gene expression in mdx mouse muscle in relation to age and exercise: aberrant mechanical–metabolic coupling and implications for pre-clinical studies in Duchenne muscular dystrophy

Camerino, G. M., Cannone, M., Giustino, A., Massari, A. M., Capogrosso, R. F., Cozzoli, A., & Luca, A. D. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu287 · Cited by 58 · see citing works

Histone Deacetylases: Molecular Mechanisms and Therapeutic Implications for Muscular Dystrophies

Sandonà, M., Cavioli, G., Renzini, A., Cedola, A., Gigli, G., Coletti, D., McKinsey, T. A., Moresi, V., & Saccone, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054306 · Cited by 57 · see citing works

Physical Exercise and Epigenetic Modulation: Elucidating Intricate Mechanisms

Sanchis-Gomar, H. P.-G., & a-Gimenez, J. G. ́. (2014) · Cited by 51 · see citing works

Selective Modulation of MicroRNA Expression with Protein Ingestion Following Concurrent Resistance and Endurance Exercise in Human Skeletal Muscle

CAMERA, D. M., Ong, J. N., Coffey, V. G., & Hawley, J. A. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00087 · Cited by 50 · see citing works

Repeated Sprints Alter Signaling Related to Mitochondrial Biogenesis in Humans

Serpiello, F. R., McKenna, M. J., Bishop, D. J., Aughey, R. J., Caldow, M. K., Cameron‐Smith, D., & Stepto, N. K. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318240067e · Cited by 48 · see citing works

Understanding the acetylome: translating targeted proteomics into meaningful physiology

Philp, A., Rowland, T., Pérez‐Schindler, J., & Schenk, S. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00399.2013 · Cited by 46 · see citing works

Opposing HDAC4 nuclear fluxes due to phosphorylation by β‐adrenergic activated protein kinase A or by activity or Epac activated CaMKII in skeletal muscle fibres

Liu, Y., & Schneider, M. F. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.256263 · Cited by 43 · see citing works

Epigenetic regulation of skeletal muscle metabolism

Howlett, K. F., & McGee, S. L. (2016) · Clinical Science · doi:10.1042/cs20160115 · Cited by 40 · see citing works

Immobilization induces nuclear accumulation of HDAC4 in rat skeletal muscle

Yoshihara, T., Machida, S., Kurosaka, Y., Kakigi, R., Sugiura, T., & Naıto, H. (2016) · The Journal of Physiological Sciences · doi:10.1007/s12576-015-0432-1 · Cited by 36 · see citing works

The evolution of metabolic regulation in animals

Seebacher, F. (2017) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2017.11.002 · Cited by 36 · see citing works

Why do anti-inflammatory therapies fail to improve insulin sensitivity?

Gao, Z., & Ye, J. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.131 · Cited by 35 · see citing works

p300 is not required for metabolic adaptation to endurance exercise training

LaBarge, S. A., Migdal, C., Buckner, E. H., Okuno, H., Gertsman, I., Stocks, B., Barshop, B. A., Nalbandian, S., Philp, A., McCurdy, C. E., et al. (2015) · The FASEB Journal · doi:10.1096/fj.15-281741 · Cited by 32 · see citing works

Defining ketone supplementation: the evolving evidence for postexercise ketone supplementation to improve recovery and adaptation to exercise

Robberechts, R., & Poffé, C. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00485.2023 · Cited by 31 · see citing works

The role of histone deacetylase 4 during chondrocyte hypertrophy and endochondral bone development

Chen, Z., Zhang, Z., Guo, L., Wei, X., Zhang, Y., Wang, X., & Lei, W. (2020) · Bone and Joint Research · doi:10.1302/2046-3758.92.bjr-2019-0172.r1 · Cited by 30 · see citing works

Role of Histone Deacetylases in Skeletal Muscle Physiology and Systemic Energy Homeostasis: Implications for Metabolic Diseases and Therapy

Tian, H., Liu, S., Ren, J. T., LEE, J. K. W., Wang, R., & Chen, P. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00949 · Cited by 31 · see citing works

Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice

Pierno, S., Camerino, G. M., Cannone, M., Liantonio, A., Bellis, M. D., Digennaro, C., Gramegna, G., Luca, A. D., Germinario, E., Danieli‐Betto, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065167 · Cited by 29 · see citing works

Histone deacetylase inhibition enhances extracellular vesicles from muscle to promote osteogenesis via miR-873-3p

Chen, M., Li, Y., Zhang, M., Ge, S., Feng, T., Chen, R., Shen, J., Li, R., Wang, Z., Xie, Y., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01976-0 · Cited by 28 · see citing works

Epigenetics and diabetic cardiomyopathy

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p38 MAPK activation and H3K4 trimethylation is decreased by lactate in vitro and high intensity resistance training in human skeletal muscle

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Genetic Determinants of Endurance: A Narrative Review on Elite Athlete Status and Performance

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Epigenetic effects of physical activity in elderly patients with cardiovascular disease

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Quantitative Proteomics Identifies Novel Nrf2-Mediated Adaptative Signaling Pathways in Skeletal Muscle Following Exercise Training

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Cognitive Dysfunction and Exercise: From Epigenetic to Genetic Molecular Mechanisms

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Acute and Chronic Resistance Training, Acute Endurance Exercise, nor Physiologically Plausible Lactate In Vitro Affect Skeletal Muscle Lactylation

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Two Locomotor Traits Show Different Patterns of Developmental Plasticity Between Closely Related Clonal and Sexual Fish

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Role of physical activity in tumor patients and possible underlying mechanisms

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Safety and Efficacy of Givinostat for Patients with Muscular Dystrophy: A Systematic Review

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Acetylated Histone Modifications: Intersection of Diabetes and Atherosclerosis

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HIGHLIGHTED TOPIC Signals Mediating Skeletal Muscle Remodeling by Activity Histone modifications and exercise adaptations

Mcgee, S. L., & Hargreaves, M. (2010)

Exercise-induced histone modifications in human skeletal muscle

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EXERCISE-INDUCED NUCLEAR EXPORT OF HDAC5 IN HUMAN SKELETAL MUSCLE

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Exercise-induced histone acetylation - playing tag with the genome

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EXERCISE AND CLASS IIa HISTONE DEACETYLASES IN HUMAN SKELETAL MUSCLE

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