The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Vitamin E as an in Vitro and in Vivo Antioxidanta
Abstract
alpha-Tocopherol has near optimal activity as a chain-breaking antioxidant. Inherent antioxidant activity plays an important part in determining overall biological activity but the phytyl tail also exerts a very important influence. The new deuterated alpha-tocopherol/GC-MS technique is providing unprecedented insight into the importance of the stereochemistry of the phytyl tail in determining bioavailability, as well as helping to discover how rapidly and effectively absorption, transport, uptake, and loss occur. Measurements of rate of turnover in tissues indicate that differences exist between different types of animals. It is possible that these tissue differences may explain the diverse range of vitamin E deficiency symptoms observed across a wide variety of animals. It is not known what is responsible for the differences in biokinetic behavior.
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Cites
Autoxidation of biological molecules. 4. Maximizing the antioxidant activity of phenols
Burton, G. W., Doba, T., Gabe, E., Hughes, L., Lee, F. L., Prasad, L., & Ingold, K. U. (1985) · Journal of the American Chemical Society · doi:10.1021/ja00310a049 · Cited by 779
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Cited by
Free radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680
Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378
Reactive Oxygen Species and the Central Nervous System
Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947
Lipid peroxidation and ferroptosis: The role of GSH and GPx4
Ursini, F., & Maiorino, M. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.027 · Cited by 1,954
Probucol and Multivitamins in the Prevention of Restenosis after Coronary Angioplasty
Tardif, J.-C., Côté, G., Lespérance, J., Bourassa, M., Lambert, J., Doucet, S., Bilodeau, L., Nattel, S., & de Guise, P. (1997) · New England Journal of Medicine · doi:10.1056/nejm199708073370601 · Cited by 565
Metadata
- Authors
- BURTON, G. W., & INGOLD, K. U.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1989-12
- Volume
- 570
- Issue
- 1
- Pages
- 7-22
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2007770728
- Cited by
- 445
- References
- 1
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- closed
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