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Cited by 78Suicide and Self-Harm StudiesSchizophrenia research and treatmentTreatment of Major Depression

Morphometric methods for studying the prefrontal cortex in suicide victims and psychiatric patients

RAJKOWSKA, GRAZYNA·1997·Annals of the New York Academy of Sciences
DOI 10.1111/j.1749-6632.1997.tb52364.x
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Abstract

Abstract Neurochemical studies demonstrate altered numbers of monoaminergic receptors in the prefrontal cortex in suicide and depression victims, implicating dysfunction of the prefrontal cortex in the neuropathology of suicide and psychiatric disorders. Neuroimaging studies in vivo have revealed an altered pattern of cortical metabolism and reductions in frontal lobe volume in patients with schizophrenia (SCZ) or depression. However, the precise morphopathology underlying these abnormalities and thier reelevance to suicide are unknown. Our recent three‐dimensional cell counting of dorsolateral prefrontal cortex from 16 postmortem SCZ brains (10 suicide completers) revealed cellular changes (increased neuronal density, and reduced laminar width and neuronal size) that may be associated with neuroimaging observations. Evaluation of the same morphometric parameters in the prefrontal cortex in seven bipolar brains (three committed suicide) revealed similarities (decreased cortical and laminar thickness) and differences (unchanged overall neuronal density and laminar densities) between morphopathology of SCZ and bipolar disorder. In another population of suicide victims with major depression (nonpsychotic), further morphopathological differences from SCZ and similarities to bipolar disorder were observed in the prefrontal cortex. From these data we can conclude that the morphopathology observed in brain tissue from suicide victims appears to vary based on psychiatric symptomatology. In order to confirm this hypothesis and to establish the specificity of morphometric findings in relation to psychiatric disorders and suicide, additional studies are warranted in nonsuicide subjects with SCZ, major depression, or bipolar disorder.

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Crossref · 10.1111/j.1749-6632.1997.tb52364.x

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  • Depressed patients show reductions in cortical volume and thickness in several frontal cortex regions, most reliably in PFo area 11, sulcal area 47, and subgenual frontal cortex.

    “Furthermore, reductions of cortical volume and thickness occur in several parts of the frontal cortex in depressed patients, with the most reliable and best characterized of these abnormalities occurring in PFo area 11 (44), the sulcal part of area 47 (45, 46), and the subgenual frontal cortex (47–50).”

    From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [44]

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Authors
RAJKOWSKA, G.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
1997-12
Volume
836
Issue
1
Pages
253-268
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/j.1749-6632.1997.tb52364.x
OpenAlex
W2073073414
Cited by
78
References
59
Citations by year
2024: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 5 · 2012: 1
FWCI
1.44
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3303 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
suicide, prefrontal cortex, morphometrics, dorsolateral prefrontal cortex, schizophrenia, bipolar disorder, major depressive disorder, neuronal density, postmortem brain, monoaminergic receptors
MeSH terms
Mental Disorders, Humans, Suicide, Tomography, Prefrontal Cortex

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