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Cited by 631Health disparities and outcomesBirth, Development, and HealthChild Abuse and Trauma

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

The Biological Embedding of Early Experience and Its Effects on Health in Adulthood

HERTZMAN, CLYDE·1999·Annals of the New York Academy of Sciences
DOI 10.1111/j.1749-6632.1999.tb08107.x
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Abstract

Explanations of the socioeconomic gradient in health status must account for the observations that the gradient cuts across a wide range of disease processes and is capable of replicating itself on new disease processes as they emerge in society. Understanding this pattern requires an understanding of how human organisms can become generally vulnerable or resilient to disease over time: a huge collation task across different disciplines. The hypothesis that best fits current evidence is that the gradient is an "emergent property" of the interaction between the developmental status of people and the material and psychosocial conditions they encounter over their life course. Within this broad formulation, special attention is given to child development, and the prospect that socioeconomic differences in the quality of early life experiences contribute to subsequent gradients in health status through socioeconomic differences in brain sculpting and the conditioning of host defense systems that depend on communication with the developing brain. The contribution to the gradient in health is theorized to occur through a combination of latent effects, pathway effects, and cumulative disadvantage.

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Crossref · 10.1111/j.1749-6632.1999.tb08107.x

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Citations

Cites

Show all 30 references

Research works printed but not linked: 15

  1. Kuh D.L. & Y. Ben‐Shlomo. 1997. A Life Course Approach to Chronic Disease Epidemiology: Tracing the Origins of Ill Health from Early to Adult Life. Oxford University Press Oxford.
  2. 10.1111/1469-7610.00343 · DOI · Paper page
  3. Barker D.J.P. Ed. 1992. Fetal and Infant Origins of Adult Disease. 1st edit. British Medical Journal. London.
  4. Palmer F.H. 1979. Long‐term gains from early intervention: findings from longitudinal studies.InProject Head Start: A Legacy of the war on poverty. E. Zigler & J. Valentine Eds. The Free Press New York.
  5. 10.1136/bmj.314.7080.547 · DOI
  6. 10.1093/oxfordjournals.bmb.a011601 · DOI
  7. Power C. & S. Matthews. 1998. Accumulation of health risks across social groups in a national longitudinal study.InHuman Biology and Social Inequality. S.S. Strickland & P.S. Shetty Eds.: 36‐57. Cambridge University Press Cambridge.
  8. Mare R.D. 1990 Socio‐economic careers and differential mortality among older men in the United States.InMeasurement and Mortality: New Approaches. J. Vallin S. de Souza & A. Polloni Eds.: 362‐387. Oxford University Press. New York.
  9. Rose R., 1995, Russia as an hour‐glass society: a constitution without citizens, East Eur. Constitut. Rev., 4, 34
  10. 10.1136/bmj.312.7037.999 · DOI
  11. Kohen D. & C. Hertzman. 1999. The importance of quality child care. Chapter 15.InVulnerable Children in Canada. D. Willms Ed.: In press.
  12. Meany M.J., 1999, Stress, maternal care, and infant brain development, Ann. N.Y. Acad, Sci., 896
  13. Suomi S.J. 1999. Developmental trajectories early experiences and community consequences: lessons from studies with rhesus monkeys.InDevelopmental Health and the Wealth of Nations. D.P. Keating & C. Hertzman Eds.: The Guildford Press New York.
  14. 10.1136/bmj.314.7080.591 · DOI
  15. 10.1016/S0140-6736(89)90266-3 · DOI

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Metadata

Authors
HERTZMAN, C.
Affiliations
University of British Columbia (CA)
Corresponding author
HERTZMAN, CLYDE
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
1999-12
Volume
896
Issue
1
Pages
85-95
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/j.1749-6632.1999.tb08107.x
OpenAlex
W1983381709
Cited by
631
References
30
Citations by year
2026: 16 · 2025: 19 · 2024: 23 · 2023: 26 · 2022: 24 · 2021: 82 · 2020: 29 · 2019: 34 · 2018: 31 · 2017: 37 · 2016: 38 · 2015: 43 · 2014: 27 · 2013: 33 · 2012: 25
FWCI
0.28
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2259 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Health › Health disparities and outcomes
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords
biological embedding, early life experience, socioeconomic gradient in health, child development, brain development, cumulative disadvantage, latent effects, developmental origins of health and disease
MeSH terms
Adult, Brain, Child, Child Development, Psychology, Child, Educational Status, Health Status, Humans, Hypothalamo-Hypophyseal System, Immunity, Innate, Parents, Pituitary-Adrenal System, Quality of Life, Social Class

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