Stress‐Induced Decrease of the Intestinal Barrier Function: The Role of Muscarinic Receptor Activation
Abstract
A bstract:Recently the breakdown of the barrier function of the intestinal epithelium after application of an experimental psychological and physical stress protocol in rats has been observed. Not only did smaller molecules pass from the luminal to the serosal side, but so also did larger proteins with the dimensions of luminal antigens and toxins. The increased permeability for macromolecules is primarily due to a decrease of the tightness of the zonula occludens, but an increased endocytotic uptake indicates that transcytosis is increased also. From studies of model systems it can be concluded that activation of the intracellular protein kinase C route by muscarinic receptor activation or histamine receptor activation can be one of the underlying cellular pathways. The physical pathway relaying the stress from the brain to the intestinal tract appears to be the parasympathetic branch of the autonomic nervous system. The difference in reaction of different strains suggests that coping style is an important determinant of the response of the intestinal barrier to stress.
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Stressful stimuli can enhance the permeability of the intestinal epithelium, which allows bacterial antigens to penetrate the gut epithelium and triggers an immune response in the intestinal mucosa.
“For example, several studies have demonstrated that stressful stimuli can enhance the permeability of the intestinal epithelium, which allows bacterial antigens to penetrate the gut epithelium and triggers an immune response in the intestinal mucosa.23-27”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [24]
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- Authors
- GROOT, J., BIJLSMA, P., KALKEREN, A. V., KILIAAN, A., SAUNDERS, P., & PERDUE, M.
- Affiliations
- University of Amsterdam (NL)
- Corresponding author
- GROOT, JACK
- ORCID
- KILIAAN, AMANDA
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2000-12
- Volume
- 915
- Issue
- 1
- Pages
- 237-246
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2095668015
- Cited by
- 44
- References
- 34
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 4 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- intestinal barrier function, stress, muscarinic receptors, tight junctions, zonula occludens, intestinal permeability, transcytosis, protein kinase C, histamine receptors, parasympathetic nervous system, coping styles, strain differences, psychological stress, physical stress
- MeSH terms
- Animals, Intestinal Absorption, Intestinal Mucosa, Receptors, Muscarinic, Stress, Physiological
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