Mechanisms of initiation and perpetuation of gut inflammation by stress

Hart, A.; Kamm, M. A.

doi:10.1046/j.1365-2036.2002.01359.x

Cited by 138Inflammatory Bowel DiseaseGastrointestinal motility and disordersGut microbiota and health

Mechanisms of initiation and perpetuation of gut inflammation by stress

Hart, A., Kamm, M. A.·2002·Alimentary Pharmacology & Therapeutics

DOI 10.1046/j.1365-2036.2002.01359.x

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Abstract

Summary: Inflammatory bowel disease involves an interaction between genetic susceptibility, a host mucosal immune response and the enteric flora. However, the relapsing and remitting course underlines the importance of other modifiers, such as psychological stress. Doctors and patients share the view that stress plays a role in the initiation and perpetuation of disease. Levels of chronic perceived stress have been shown to correlate with symptom relapse and mucosal appearance, and stress management therapy has been shown to be beneficial. Animal models provide further evidence that stress may play a role in disease initiation and reactivation. Elucidation of the gut–brain–immune axis has provided insight into the mechanisms by which stress may result in gut inflammation. Stress can alter intestinal physiological function. Stress can increase gut permeability, increase ion secretion by a mechanism involving neural stimulation or mast cells, increase mucin release and deplete goblet cells. Stress causes parasympathetic activation via a mechanism involving corticotropin releasing factor, ultimately affecting mucosal mast cells. Stress also results in increased bacterial adherence and decreased luminal lactobacilli. As a result of all these changes luminal antigens may gain access to the epithelium, causing inflammation.

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Psychological stress adversely affects intestinal barrier function, resulting in increased intestinal permeability.
“It is well-known that intestinal barrier function can be adversely affected by acute or chronic psychological stress, resulting in increased intestinal permeability [2], [3], [4], [5], [6]”
From CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α (2012) · cites this paper as [2]

Psychological Stress and Susceptibility to the Common Cold
Cohen, S., Tyrrell, D. A. J., & Smith, A. P. (1991) · New England Journal of Medicine · doi:10.1056/nejm199108293250903 · Cited by 1,712 · see citing works
A New Measure of Health Status for Clinical Trials in Inflammatory Bowel Disease
Guyatt, G., Mitchell, A., Irvine, E. J., Singer, J., Williams, N., Goodacre, R. L., & Tompkins, C. (1989) · Gastroenterology · doi:10.1016/s0016-5085(89)80080-0 · Cited by 1,289 · see citing works
Slowing of wound healing by psychological stress
Kiecolt-Glaser, J. K., Marucha, P. T., Mercado, A. M., Malarkey, W. B., & Glaser, R. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92899-5 · Cited by 1,104 · see citing works
Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain.
Lovenberg, T. W., Liaw, C. W., Grigoriadis, D. E., Clevenger, W., Chalmers, D. T., Souza, E. B. D., & Oltersdorf, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.836 · Cited by 846 · see citing works
Psychosocial Modifiers of Immunocompetence in Medical Students
Kiecolt‐Glaser, J. K., Garner, W. L., Speicher, C. E., Penn, G. M., Holliday, J. E., & Glaser, R. (1984) · Psychosomatic Medicine · doi:10.1097/00006842-198401000-00003 · Cited by 781 · see citing works
The role of psychological and biological factors in postinfective gut dysfunction
Gwee, K.-A., Leong, Y.-L., Graham, C., McKendrick, M. W., Collins, S. M., Walters, S. J., Underwood, J. E., & Read, N. W. (1999) · Gut · doi:10.1136/gut.44.3.400 · Cited by 764 · see citing works
Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives
Hollander, D., Vadheim, C. M., Brettholz, E., Petersen, G. M., Delahunty, T., & Rotter, J. I. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-6-883 · Cited by 762 · see citing works
Quality of life: A valid and reliable measure of therapeutic efficacy in the treatment of inflammatory bowel disease
Irvine, E. J., Feagan, B. G., Rochon, J., Archambault, A., Fedorak, R. N., Groll, A., Kinnear, D. G., Saibil, F. G., & McDonald, J. W. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90585-1 · Cited by 709 · see citing works
Suppression of Lymphocyte Stimulation Following Bereavement
Schleifer, S. J. (1983) · JAMA · doi:10.1001/jama.1983.03340030034024 · Cited by 642 · see citing works
Intestinal permeability and the prediction of relapse in Crohn's disease
Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., & Lochs, H. (1993) · The Lancet · doi:10.1016/0140-6736(93)90882-h · Cited by 626 · see citing works
Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention
Mertz, H., Morgan, V. L., Tanner, G., Pickens, D. R., Price, R. R., Shyr, Y., & KESSLER, R. M. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70170-3 · Cited by 585 · see citing works
Intestinal mucosal mast cells in normal and nematode-infected rat intestines are in intimate contact with peptidergic nerves.
Stead, R. H., Tomioka, M., Quinonez, G. E., Simon, G. T., Felten, S. Y., & Bienenstock, J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.9.2975 · Cited by 554 · see citing works
Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo
Karalis, K. P., Sano, H., Redwine, J. M., LISTWAK, S. J., Wilder, R. L., & Chrousos, G. P. (1991) · Science · doi:10.1126/science.1925600 · Cited by 482 · see citing works
CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues
Lovenberg, T. W., Chalmers, D. T., Liu, C., & Souza, E. B. D. (1995) · Endocrinology · doi:10.1210/endo.136.9.7544278 · Cited by 457 · see citing works
Stress and Exacerbation in Ulcerative Colitis: A Prospective Study of Patients Enrolled in Remission
Levenstein, S., Prantera, C., Varvo, V., Scribano, M. L., Andreoli, A., Luzi, C., Arcà, M., Berto, E., Milite, G., & Marcheggiano, A. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02012.x · Cited by 451 · see citing works
Corticotropin-Releasing Hormone Induces Skin Mast Cell Degranulation and Increased Vascular Permeability, A Possible Explanation for Its Proinflammatory Effects
Theoharides, T. C., Singh, L. K., Boucher, W. S., Pang, X., Létourneau, R., Webster, E., & Chrousos, G. P. (1998) · Endocrinology · doi:10.1210/endo.139.1.5660 · Cited by 447 · see citing works
Level of chronic life stress predicts clinical outcome in irritable bowel syndrome
Bennett, E. J., Tennant, C. C., Piesse, C., Badcock, C.-A., & Kellow, J. E. (1998) · Gut · doi:10.1136/gut.43.2.256 · Cited by 405 · see citing works
Stress-induced modulation of the immune response to recombinant hepatitis B vaccine.
Glaser, R., Kiecolt‐Glaser, J. K., Bonneau, R. H., Malarkey, W. B., Kennedy, S., & Hughes, J. (1992) · Psychosomatic Medicine · doi:10.1097/00006842-199201000-00005 · Cited by 354 · see citing works
Is small intestinal permeability really increased in relatives of patients with Crohn's disease?
May, G. R., Sutherland, L. R., & Meddings, J. B. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90638-s · Cited by 316 · see citing works
Survey of the AGA Membership Relating to Patients With Functional Gastrointestinal Disorders
Mitchell, C. M., & Drossman, D. A. (1987) · Gastroenterology · doi:10.1016/s0016-5085(87)91099-7 · Cited by 292 · see citing works
Environmental stress–induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat
Meddings, J. B., & Swain, M. G. (2000) · Gastroenterology · doi:10.1053/gast.2000.18152 · Cited by 269 · see citing works
Clustering of increased small intestinal permeability in families with Crohn's disease
Peeters, M., Geypens, B. J., Claus, D., Nevens, H., Ghoos, Y. F., Verbeke, G. N., Baert, F., Vermeire, S., VLIETINCK, R. F., & Rutgeerts, P. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70174-4 · Cited by 262 · see citing works
The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimental colitis
Qiu, B., Vallance, B. A., Blennerhassett, P. A., & Collins, S. M. (1999) · Nature Medicine · doi:10.1038/13503 · Cited by 252 · see citing works
Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells
Castagliuolo, I., LaMont, J. T., Qiu, B., Fleming, S. M., Bhaskar, K. R., Nikulásson, S. Þ., Kornetsky, C. H., & Pothoulakis, C. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.271.5.g884 · Cited by 251 · see citing works
Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat
Santos, J., Saunders, P. R., Hanssen, N. P. M., Yang, P., Yates, D. A., Groot, J. A., & Perdue, M. H. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.2.g391 · Cited by 251 · see citing works
Release of mast cell mediators into the jejunum by cold pain stress in humans
Santos, J., Saperas, E., Nogueiras, C., Mourelle, M., Antolín, M., Cadahia, A., & Malagelada, J. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70577-3 · Cited by 237 · see citing works
Tachykinins in the gut. Part II. Roles in neural excitation, secretion and inflammation
Holzer, P. D., & Holzer‐Petsche, U. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(96)00196-9 · Cited by 227 · see citing works
Stress stimulates transepithelial macromolecular uptake in rat jejunum
Kiliaan, A. J., Saunders, P. R., Bijlsma, P. B., Berin, M. C., Taminiau, J. A., Groot, J. A., & Perdue, M. H. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.5.g1037 · Cited by 223 · see citing works
Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine
Saunders, P. R., Kosecka, U., McKay, D. M., & Perdue, M. H. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.267.5.g794 · Cited by 215 · see citing works
Stress-induced intracranial mast cell degranulation: A corticotropin-releasing hormone-mediated effect
Theoharides, T. C., Spanos, C., Pang, X., Alferes, L., Ligris, K., Letourneau, R., Rozniecki, J. J., Webster, E., & Chrousos, G. P. (1995) · Endocrinology · doi:10.1210/endo.136.12.7588332 · Cited by 214 · see citing works
Chronic stress impairs rat growth and jejunal epithelial barrier function: role of mast cells
Santos, J., Benjamin, M. A., Yang, P., Prior, T., & Perdue, M. H. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.278.6.g847 · Cited by 205 · see citing works
Psychological stress and disease activity in ulcerative colitis: a multidimensional cross-sectional study.
Levenstein, S., Prantera, C., Varvo, V., Scribano, M. L., Berto, E., Andreoli, A., & Luzi, C. (1994) · PubMed · Cited by 188 · see citing works
Why do patients with ulcerative colitis relapse?
Riley, S. A., Mani, V., Goodman, M. J., & Lucas, S. B. (1990) · Gut · doi:10.1136/gut.31.2.179 · Cited by 182 · see citing works
The Influence of Psychological Stress on the Immune Response to Vaccinesa
Glaser, R., Kiecolt‐Glaser, J. K., Malarkey, W. B., & Sheridan, J. F. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09603.x · Cited by 180 · see citing works
Corticotropin‐Releasing Factor and the Brain‐Gut Motor Response to Stress
Taché, Y., Martı́nez, V., Million, M., & Rivier, J. (1999) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/1999/375916 · Cited by 177 · see citing works
Relevance of Major Stress Events as an Indicator of Disease Activity Prevalence in Inflammatory Bowel Disease
Duffy, L. C., Zielezny, M. A., Marshall, J. R., Byers, T. E., Weiser, M. M., Phillips, J. F., Calkins, B. M., Ogra, P. L., & Graham, S. (1991) · Behavioral Medicine · doi:10.1080/08964289.1991.9937553 · Cited by 176 · see citing works
Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P
Sturiale, S., Barbara, G., Qiu, B., Figini, M., Geppetti, P., Gerard, N. P., Gerard, C. J., Grady, E. F., Bunnett, N. W., & Collins, S. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11653 · Cited by 175 · see citing works
Illness Experience and Life Stresses in Patients with Irritable Colon and with Ulcerative Colitis
Mendeloff, A. I., Monk, M., Siegel, C. I., & Lilienfeld, A. M. (1970) · New England Journal of Medicine · doi:10.1056/nejm197001012820104 · Cited by 172 · see citing works
Intestinal permeability changes in response to acetylsalicylic acid in relatives of patients with Crohn's disease
Hilsden, R. J., Meddings, J., & Sutherland, L. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8613043 · Cited by 169 · see citing works
A study of the association between Crohn's disease and psychiatric illness
Helzer, J. E., Chammas, S., Norland, C. C., Stillings, W. A., & Alpers, D. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90418-9 · Cited by 168 · see citing works
Role of mast cells in ion transport abnormalities associated with intestinal anaphylaxis. Correction of the diminished secretory response in genetically mast cell-deficient W/Wv mice by bone marrow transplantation.
Perdue, M. H., Masson, S., Wershil, B. K., & Galli, S. J. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115047 · Cited by 162 · see citing works
Personality profile and affective state of patients with inflammatory bowel disease.
Robertson, D. A., Ray, J., Diamond, I., & Edwards, J. (1989) · Gut · doi:10.1136/gut.30.5.623 · Cited by 156 · see citing works
Do Life Events or Depression Exacerbate Inflammatory Bowel Disease?: A Prospective Study
North, C. S., Alpers, D. H., Helzer, J. E., Spitznagel, E. L., & Clouse, R. E. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-5-381 · Cited by 152 · see citing works
RENAL BIOPS IN CHILDREN.
Hayton-Williams, D. S. (1965) · PubMed · Cited by 151 · see citing works
Inhibition of Mantoux Reaction by Direct Suggestion under Hypnosis
Black, S. M., Humphrey, J., & Niven, J. S. F. (1963) · BMJ · doi:10.1136/bmj.1.5346.1642-b · Cited by 149 · see citing works
Previous inflammation alters the response of the rat colon to stress
Collins, S. M., McHugh, K., Jacobson, K., Khan, I., Riddell, R. H., Murase, K., & Weingarten, H. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70012-4 · Cited by 148 · see citing works
Stimulatory effect of corticotropin-releasing neurohormone on human lymphocyte proliferation and interleukin-2 receptor expression
Singh, V. K. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90058-1 · Cited by 146 · see citing works
Corticotropin releasing hormone in colonic mucosa in patients with ulcerative colitis.
Kawahito, Y., Sano, H., Mukai, S., Asai, K., Kimura, S., Yamamura, Y., Kato, H., Chrousos, G. P., Wilder, R. L., & Kondo, M. (1995) · Gut · doi:10.1136/gut.37.4.544 · Cited by 146 · see citing works
Enteropathogenic Escherichia coli decreases the transepithelial electrical resistance of polarized epithelial monolayers
Canil, C., Rosenshine, I., Ruschkowski, S., Donnenberg, M. S., Kaper, J. B., & Finlay, B. B. (1993) · Infection and Immunity · doi:10.1128/iai.61.7.2755-2762.1993 · Cited by 143 · see citing works
Interleukin-6 expression and regulation in rat enteric glial cells
Rühl, A., Franzke, S., Collins, S. M., & Stremmel, W. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.6.g1163 · Cited by 140 · see citing works
Corticotrophin-releasing factor-like immunoreactivity and mRNA in human leukocytes
Stephanou, A., Jessop, D. S., Knight, R. A., & Lightman, S. L. (1990) · Brain Behavior and Immunity · doi:10.1016/0889-1591(90)90007-d · Cited by 133 · see citing works
Quantification of the placebo response in ulcerative colitis
Ilnyckyj, A., Shanahan, F., Anton, P., Cheang, M., & Bernstein, C. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.pm9178676 · Cited by 133 · see citing works
Beneficial effects of local or systemic lidocaine in experimental colitis
McCafferty, D., Sharkey, K. A., & Wallace, J. L. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.266.4.g560 · Cited by 132 · see citing works
Evaluation of a psychological treatment for inflammatory bowel disease
Schwarz, S. P., & Blanchard, E. B. (1991) · Behaviour Research and Therapy · doi:10.1016/0005-7967(91)90045-5 · Cited by 131 · see citing works
Major histocompatibility class II expression on the small intestinal nervous system in Crohn's disease
Geboes, K., Rutgeerts, P. J., Ectors, N., Mebis, J., PENNINCKX, F. M., Vantrappen, G. R., & Desmet, V. J. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90832-j · Cited by 130 · see citing works
Susceptibility of Lewis and Fischer rats to stress-induced worsening of TNB-colitis: protective role of brain CRF
Million, M., Taché, Y., & Anton, P. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.4.g1027 · Cited by 128 · see citing works
A controlled study of the association between ulcerative colitis and psychiatric diagnoses
Helzer, J. E., Stillings, W. A., Chammas, S., Norland, C. C., & Alpers, D. (1982) · Digestive Diseases and Sciences · doi:10.1007/bf01296730 · Cited by 125 · see citing works
Immunocytochemical localization of corticotropin releasing factor (CRF) in the rat spinal cord
Merchenthaler, I. J., Hynes, M., Vígh, S., Shally, A. V., & Petrusz, P. (1983) · Brain Research · doi:10.1016/0006-8993(83)91001-6 · Cited by 123 · see citing works
Local secretion of corticotropin-releasing hormone by enterochromaffin cells in human colon
Kawahito, Y., Sano, H., Kawata, M., Yuri, K., Mukai, S., Yamamura, Y., Kato, H., Chrousos, G. P., Wilder, R. L., & Kondo, M. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90743-9 · Cited by 122 · see citing works
Quality of life in inflammatory bowel disease: the interaction of disease activity with psychosocial function.
Turnbull, G. K., & Vallis, M. (1995) · PubMed · Cited by 121 · see citing works
A stress management programme for inflammatory bowel disease patients
Milne, B. J., Joachim, G., & Niedhardt, J. (1986) · Journal of Advanced Nursing · doi:10.1111/j.1365-2648.1986.tb01288.x · Cited by 118 · see citing works
Cholinergic nerves mediate stress-induced intestinal transport abnormalities in Wistar-Kyoto rats
Saunders, P. R., Hanssen, N. P. M., & Perdue, M. H. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.2.g486 · Cited by 118 · see citing works
The Influence of Mast Cells on Pathways of Transepithelial Antigen Transport in Rat Intestine
Berin, M. C., Kiliaan, A. J., Yang, P., Groot, J. A., Kitamura, Y., & Perdue, M. H. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.5.2561 · Cited by 109 · see citing works
Effect of psychological stress on salt and water transport in the human jejunum
Barclay, G. R., & Turnberg, L. A. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90319-2 · Cited by 109 · see citing works
Corticotropin-Releasing Factor Receptors in Mouse Spleen: Identification of Receptor-Bearing Cells as Resident Macrophages
Webster, E. L., Tracey, D. E., Jutila, M. A., Wolfe, S. A., & Souza, E. B. D. (1990) · Endocrinology · doi:10.1210/endo-127-1-440 · Cited by 108 · see citing works
Rectal Mucosal Adrenergic Innervation and Enterochromaffin Cells in Ulcerative Colitis and Irritable Colon
Kyösola, K. T., Penttilä, O., & Salaspuro, M. P. (1977) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365527709180942 · Cited by 106 · see citing works
CD45RO expression on circulating CD19+ B cells in Crohn's disease correlates with intestinal permeability
Yacyshyn, B., & Meddings, J. B. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90017-9 · Cited by 103 · see citing works
Influence of perceived psychological stress and distress on antibody response to low dose rDNA hepatitis B vaccine
Jabaaij, L., Grosheide, P. M., Heijtink, R. A., Duivenvoorden, H. J., BALLIEUX, R. E., & Vingerhoets, A. J. J. M. (1993) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(93)90138-6 · Cited by 103 · see citing works
Colonic mucin release in response to immobilization stress is mast cell dependent
Castagliuolo, I., Wershil, B. K., Karalis, K. P., Pasha, A., Nikulásson, S. Þ., & Pothoulakis, C. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.274.6.g1094 · Cited by 102 · see citing works
Long-term monitoring of psychosocial stress and symptomatology in inflammatory bowel disease
Greene, B. R., Blanchard, E. B., & Wan, C. K. (1994) · Behaviour Research and Therapy · doi:10.1016/0005-7967(94)90114-7 · Cited by 100 · see citing works
Mast cell mediated ion transport in intestine from patients with and without inflammatory bowel disease
Crowe, S. E., Luthra, G. K., & Perdue, M. H. (1997) · Gut · doi:10.1136/gut.41.6.785 · Cited by 96 · see citing works
Psychiatric study of a consecutive series of 34 patients with ulcerative colitis.
Feldman, F., Cantor, D., Soll, S., & Bachrach, W. H. (1967) · BMJ · doi:10.1136/bmj.3.5556.14 · Cited by 95 · see citing works
Novel Intestinal Helicobacter Species Isolated from Cotton-Top Tamarins ( Saguinus oedipus ) with Chronic Colitis
Saunders, K. E., Shen, Z., Dewhirst, F. E., et al. (1999) · Journal of Clinical Microbiology · doi:10.1128/jcm.37.1.146-151.1999 · Cited by 93 · see citing works
Effect of Psychotherapy on the Course of Crohn's Disease: Results of the German Prospective Multicenter Psychotherapy Treatment Study on Crohn's Disease
Jantschek, G. (1998) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365529850172386 · Cited by 92 · see citing works
The effect of dexamethasone administration on rat intestinal permeability: The role of bacterial adherence
Spitz, J., Hecht, G. A., Taveras, M., Aoys, E., & Alverdy, J. C. (1994) · Gastroenterology · doi:10.1016/s0016-5085(94)94155-6 · Cited by 87 · see citing works
A neurotensin antagonist, SR 48692, inhibits colonic responses to immobilization stress in rats.
Castagliuolo, I., Leeman, S. E., Bartolák‐Suki, E., Nikulásson, S. Þ., Qiu, B., Carraway, R. E., & Pothoulakis, C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12611 · Cited by 81 · see citing works
Psychological distress and levels of disease activity in inflammatory bowel disease.
Porcelli, P., Zaka, S., Centonze, S., & Sisto, G. (1994) · PubMed · Cited by 71 · see citing works
Large Bowel Disorders. I. Illness Configuration and Life Events
Fava, G. A., & Pavan, L. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000287001 · Cited by 69 · see citing works
Coexistence of glucocorticoid receptor-like immunoreactivity with neuropeptides in the hypothalamic paraventricular nucleus
Ceccatelli, S., Cintra, A., H�kfelt, T., Fuxé, K., Wikstr�m, A.-C., & Gustafsson, J. �. (1989) · Experimental Brain Research · doi:10.1007/bf00230684 · Cited by 67 · see citing works
Glucocorticoid regulation of the humoral immune system. I. In vivo effects of dexamethasone on IgA and IgG in serum and at mucosal surfaces.
Wira, C. R., Sandoe, C. P., & Steele, M. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.1.142 · Cited by 65 · see citing works
Neurotensin Activates Tuberoinfundibular Dopamine Neurons and Increases Serum Corticosterone Concentrations in the Rat
Gudelsky, G. A., Berry, S. A., & Meltzer, H. Y. (2008) · Neuroendocrinology · doi:10.1159/000125176 · Cited by 65 · see citing works
The “Natural History” of Ulcerative Colitis
Meyers, S., & Janowitz, H. D. (1989) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-198902000-00008 · Cited by 65 · see citing works
Characteristics of the intestinal epithelial barrier during dietary manipulation and glucocorticoid stress
Spitz, J. C., Ghandi, S., Taveras, M., Aoys, E., & Alverdy, J. C. (1996) · Critical Care Medicine · doi:10.1097/00003246-199604000-00015 · Cited by 64 · see citing works
Modulation of immune response to rDNA hepatitis B vaccination by psychological stress
Jabaaij, L., van Hattum, J., Vingerhoets, A. J. J. M., Oostveen, F. G., Duivenvoorden, H. J., & BALLIEUX, R. E. (1996) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(96)00123-7 · Cited by 61 · see citing works
Evidence that Colitis Is Initiated by Environmental Stress and Sustained by Fecal Factors in the Cotton-Top Tamarin (Saguinus oedipus)
Wood, J. D., Peck, O. C., Tefend, K. S., Stonerook, M. J., Caniano, D. A., Mutabagani, K. H., Lhoták, Š., & Sharma, H. M. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005485215128 · Cited by 61 · see citing works
Hematology and immunology studies: the second manned Skylab mission.
KIMZEY, S. L., Johnson, P. C., Ritzmann, S. E., & Mengel, C. E. (1976) · PubMed · Cited by 58 · see citing works
The Treatment of Ulcerative Colitis
Svartz, N. (1954) · Gastroenterology · doi:10.1016/s0016-5085(54)80065-5 · Cited by 55 · see citing works
Relapse-Precipitating Life Events and Feelings in Patients with Inflammatory Bowel Disease
von Wietersheim, J., Köhler, T. C., & Feiereis, H. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000288617 · Cited by 53 · see citing works
The Treatment of Ulcerative Colitis. II
Grace, W. J., Pinsky, R. H., & Wolff, H. G. (1954) · Gastroenterology · doi:10.1016/s0016-5085(54)80026-6 · Cited by 51 · see citing works
Local production of corticotropin releasing hormone is increased in experimental intestinal inflammation in rats.
van Tol, E. A., Petrusz, P., Lund, P. K., Yamauchi, M., & Sartor, R. B. (1996) · Gut · doi:10.1136/gut.39.3.385 · Cited by 51 · see citing works
PSYCHOSOCIAL FACTORS IN INFLAMMATORY BOWEL DISEASE
Talal, A. H., & Drossman, D. A. (1995) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(21)00219-3 · Cited by 50 · see citing works
Psychotherapeutic Interventions in Alexithymic Patients
Freyberger, H., Künsebeck, H.-W., Lempa, W., Wellmann, W., & Avenarius, H. J. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000287896 · Cited by 47 · see citing works
Both crypt and villus intestinal goblet cells secrete mucin in response to cholinergic stimulation
Phillips, T. E. (1992) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1992.262.2.g327 · Cited by 46 · see citing works
Relapsing ulcerative colitis associated with spinal cord stimulation
Kemler, M. A., Barendse, G. A. M., & van Kleef, M. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70570-6 · Cited by 45 · see citing works
The Response to Psychotherapy in Chronic Ulcerative Colitis
Karush, A., Daniels, G. E., OʼCONNOR, J. F., & STERN, L. O. (1968) · Psychosomatic Medicine · doi:10.1097/00006842-196805000-00001 · Cited by 45 · see citing works
Ulcerative Colitis-Like Lesion in Siamang Gibbons
Stout, C., & Snyder, R. L. (1969) · Gastroenterology · doi:10.1016/s0016-5085(19)33897-1 · Cited by 45 · see citing works
Stress‐Induced Decrease of the Intestinal Barrier Function: The Role of Muscarinic Receptor Activation
GROOT, J., BIJLSMA, P., KALKEREN, A. V., KILIAAN, A., SAUNDERS, P., & PERDUE, M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05247.x · Cited by 44 · see citing works
NON-SPECIFIC ULCERATIVE COLITIS IN BEDOUIN ARABS
Salem, S., & Shubair, K. S. (1967) · The Lancet · doi:10.1016/s0140-6736(67)91094-x · Cited by 43 · see citing works
Lag Time between Stress Events and Risk of Recurrent Episodes of Inflammatory Bowel Disease
Duffy, L. C., Zielezny, M. A., Marshall, J. R., Weiser, M. M., Phillips, J. F., Byers, T., Calkins, B. M., Graham, S., & Ogra, P. L. O. (1991) · Epidemiology · doi:10.1097/00001648-199103000-00009 · Cited by 43 · see citing works
Neurotensin stimulates Cl− secretion in human colonic mucosa in vitro: Role of adenosine
Riegler, M. F., Castagliuolo, I., Wang, C., Wlk, M., Sogukoglu, T., Wenzl, E., Matthews, J. B., & Pothoulakis, C. (2000) · Gastroenterology · doi:10.1053/gast.2000.9310 · Cited by 43 · see citing works
Corticotropin-releasing factor is contained within perikarya and nerve fibres of rat duodenum
Wolter, H. J. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)90486-8 · Cited by 31 · see citing works
A Gut Reaction--Lymphoepithelial Communication in the Intestine
Shanahan, F. (1997) · Science · doi:10.1126/science.275.5308.1897 · Cited by 30 · see citing works
Involvement of central dopamine and D1 receptors in stress-induced colonie motor alterations in rats
Bueno, L. P., Gué, M., Fabre‐Nys, C., & Junien, J. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90018-s · Cited by 28 · see citing works
Advances in Psychoneuroimmunology
Berczi, I., & Szelényi, J. (1994) · Springer eBooks · doi:10.1007/978-1-4757-9104-4 · Cited by 27 · see citing works
The Clinical Course and Prognostic Determinants of the Irritable Bowel Syndrome: A Literature Review
Muris, J. W. M. (1998) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365529850171783 · Cited by 27 · see citing works
Brain-gut interactions in ulcerative colitis
Peck, O. C., & Wood, J. D. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70157-0 · Cited by 26 · see citing works
Central Administration of Neurotensin Stimulates Hypothalamic‐Pituitary‐Adrenal Activity
Rowe, W. B., Viau, V., Meaney, M. J., & Quirion, R. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb27378.x · Cited by 25 · see citing works
Relationship between structure and function of liver mitochondria from hibernating and active ground squirrels, Citellus undulatus
Brustovetsky, N. N., Egorova, M. V., Iljasova, E. N., et al. (1993) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(93)90017-y · Cited by 24 · see citing works
The Response to Psychotherapy in Chronic Ulcerative Colitis
Karush, A., Daniels, G. E., OʼCONNOR, J. F., & STERN, L. O. (1969) · Psychosomatic Medicine · doi:10.1097/00006842-196905000-00002 · Cited by 24 · see citing works
Psychological factors in ulcerative colitis in man and gibbon.
Gl, E. (1969) · PubMed · Cited by 23 · see citing works
Row replacement algorithms for screen editors
Meyers, E. W., & Miller, W. (1989) · ACM Transactions on Programming Languages and Systems · doi:10.1145/59287.59290 · Cited by 22 · see citing works
ONSET SETTING IN INFLAMMATORY BOWEL DISEASE
Hislop, I. G. (1974) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1974.tb93490.x · Cited by 21 · see citing works
A Double Standard for Psychosomatic Papers?
Engel, G. L., & Salzman, L. F. (1973) · New England Journal of Medicine · doi:10.1056/nejm197301042880112 · Cited by 20 · see citing works
The need of a physiologic and pathophysiologic definition of stress
Mathé, G. (2000) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(00)89043-5 · Cited by 20 · see citing works
Patient perceptions of causes of inflammatory bowel disease.
Pr, S., Ac, B., & Mr, S. (1994) · PubMed · Cited by 19 · see citing works
The role of the neurotransmitters acetylcholine and noradrenaline in the pathogenesis of stress ulcers
Gatón, J., Gandara, F., & Velasco, A. (1993) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/0742-8413(93)90263-k · Cited by 10 · see citing works
Relapsing ulcerative colitis after spinal cord stimulation: A case of intestinal neurogenic inflammation?
Barbara, G., GIORGIO, R. D., Stanghellini, V., et al. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70425-7 · Cited by 9 · see citing works
AN OBJECTIVE STUDY OF PSYCHOLOGICAL FACTORS IN ULCERATIVE COLITIS IN CHILDREN.
ALEXANDER, T. (1965) · PubMed · Cited by 8 · see citing works
New trends in psychosomatic research.
Jb, M. (1977) · PubMed · Cited by 7 · see citing works
Placebos in medicine.
Cn, B. (1999) · PubMed · Cited by 7 · see citing works
Social stress induces reversible inflammation and persistent epithelial barrier dysfunction in the rat intestine
Santos, J., Antolı́n, M., & Malagelada, J. R. (2001) · Gastroenterology · doi:10.1016/s0016-5085(08)80279-x · Cited by 5 · see citing works
Psychological and Neural Regulation of Intestinal Hypersensitivity
DJURIĆ, V. J., Bienenstock, J., & Perdue, M. H. (1994) · Springer eBooks · doi:10.1007/978-1-4757-9104-4_25 · Cited by 4 · see citing works
Chronic psychological stress induces mucosal inflammation in the ileum and colon of Naïve rats: Role of mast cells
Söderholm, J. D., Yang, P., Vohra, A., et al. (2001) · Gastroenterology · doi:10.1016/s0016-5085(08)83455-5 · Cited by 2 · see citing works
Early maternal deprivation predisposes adult rats to colonic mucosal barrier dysfunction in response to mild stress
Söderholm, J. D., Yates, D. A., MacQUEEN, G. M., et al. (2001) · Gastroenterology · doi:10.1016/s0016-5085(08)80115-1 · Cited by 2 · see citing works
High-Level Care of a Twin Infant by a Male Rhesus Macaque
Capitanio, J. P., & Taub, D. M. (1992) · Folia Primatologica · doi:10.1159/000156615 · Cited by 2 · see citing works
Chronic psychological stress induces epithelial barrier disruption, bacterial penetration, and mucosal inflammation in ileum and colon of naïve rats
Söderholm, J. D., Yang, P., Vohra, A., et al. (2001) · Gastroenterology · doi:10.1016/s0016-5085(08)80349-6 · Cited by 2 · see citing works
Urocortin and corticotropin-releasing factor (CRF) receptor type 1 mRNA are expressed in the rat colon
Million, M., Sanchez‐Watts, G., Miampamba, M., et al. (2001) · Gastroenterology · doi:10.1016/s0016-5085(08)80857-8 · Cited by 1 · see citing works
Mast cell histamine mediates neurotensin-enhanced 3H-taurocholate absorption in jejunum
Gui, X. S., & Carraway, R. E. (2001) · Gastroenterology · doi:10.1016/s0016-5085(08)81552-1 · Cited by 1 · see citing works
Chronic psychological stress induces mucosal inflammation in the ileum and colon of Naïve rats: Role of mast cells
SODERHOLM, J., YANG, P., Vohra, A., et al. (2001) · Gastroenterology · doi:10.1016/s0016-5085(01)83455-7 · Cited by 1 · see citing works
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Anderson, R. C., Cookson, A. L., McNabb, W. C., Park, Z., McCann, M. J., Kelly, W. J., & Roy, N. C. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-316 · Cited by 510 · see citing works
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Authors: Hart, A., & Kamm, M. A.
Affiliations: St Mark's Hospital (GB)
Corresponding author: Kamm, M. A.
ORCID: Hart, A.
Kamm, M. A.
Venue: Alimentary Pharmacology & Therapeutics
Publisher: Wiley
Published: 2002-12
Volume: 16
Issue: 12
Pages: 2017-2028
ISSN: 0269-2813 (ISSN-L)
1365-2036
DOI: 10.1046/j.1365-2036.2002.01359.x
OpenAlex: W1985015494
Cited by: 138
References: 130
Citations by year: 2025: 2 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 14 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 8 · 2013: 11 · 2012: 8
FWCI: 0.70
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 8 d)
Locations: Alimentary Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: inflammatory bowel disease, psychological stress, intestinal inflammation, gut-brain-immune axis, intestinal permeability, mast cells, goblet cells, mucin, corticotropin-releasing factor, parasympathetic activation, bacterial adhesion, lactobacilli, intestinal epithelium, recurrence
MeSH terms: Animals, Humans, Intestinal Absorption, Intestinal Mucosa, Neurosecretory Systems, Permeability, Stress, Psychological, Inflammatory Bowel Diseases, Immunity, Mucosal

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Mechanisms of initiation and perpetuation of gut inflammation by stress

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