The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Role of Neurotransmitters in Sensitization of Pain Responses
Abstract
A bstract:Injection of capsaicin into the skin results in pain, primary heat and mechanical hyperalgesia, and secondary mechanical allodynia and hyperalgesia. Sensory receptors in the area of secondary mechanical allodynia and hyperalgesia are unaffected, and so the sensory changes must be due to central actions of the initial intense nociceptive discharge that follows the capsaicin injection. Central sensitization of the responses of spinothalamic tract neurons lasts several hours, but can be prevented by spinal cord administration of non‐NMDA and NMDA glutamate receptor antagonists or NK1 substance P receptor antagonists. The long‐lasting increase in excitability of spinothalamic tract cells depends on the activation of several second messenger cascades (PKC, PKA, and NO/PKG signal transduction pathways). The excitability change also depends on activation of calcium/calmodulin‐dependent kinase II, which is consistent with the proposal that this central sensitization response is a form of long‐term potentiation.
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Cites
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., & Julius, D. (1998) · Neuron · doi:10.1016/s0896-6273(00)80564-4 · Cited by 3,081
Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.
Holzer, P. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06664-5 · Cited by 1,774
Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation
Chen, L., & Mae Huang, L.-Y. (1992) · Nature · doi:10.1038/356521a0 · Cited by 965
Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms
LaMotte, R. H., Shain, C. N., Simone, D. A., & Tsai, E. F. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.1.190 · Cited by 937
Torebjörk, H. E., Lundberg, L. E., & LaMotte, R. H. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019069 · Cited by 786
Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons
Simone, D. A., Sorkin, L. S., Oh, U., Chung, J. M., Owens, C., LaMotte, R. H., & Willis, W. D. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.1.228 · Cited by 627
Self-citationLaMotte, R. H., Lundberg, L. E., & Torebjörk, H. E. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019068 · Cited by 595
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Cited by
Models and Mechanisms of Hyperalgesia and Allodynia
Sandkühler, J. (2009) · Physiological Reviews · doi:10.1152/physrev.00025.2008 · Cited by 1,148
Neuropathic pain: mechanisms and their clinical implications
Cohen, S. P., & Mao, J. (2014) · BMJ · doi:10.1136/bmj.f7656 · Cited by 802
Novel pharmacotherapy for fibromyalgia
Wood, P. B., Holman, A. J., & Jones, K. D. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.6.829 · Cited by 30
Metadata
- Authors
- Willis, W. D.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2001-03
- Volume
- 933
- Issue
- 1
- Pages
- 142-156
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1969730957
- Cited by
- 277
- References
- 38
- FWCI
- 11.05
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
