Novel pharmacotherapy for fibromyalgia
Abstract
Fibromyalgia is a common disorder that is characterized by chronic widespread pain, tenderness to light palpation, fatigue and sleep disturbances. The present lack of a well-accepted model of the disorder has hampered progress towards adequate treatment. A review of potential models to explain the pathophysiology underlying its primary symptom (i.e., chronic widespread pain) lends insight on the therapeutic potential of novel therapies. Following this, a mechanistic evaluation of those medications that are under consideration for the treatment of the disorder is offered. Adequate treatment will be likely to involve the identification of biologic subgroups within the greater fibromyalgia construct. Key insights from basic research are the basis for increased optimism for effective relief among patients and clinicians.
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Effective pharmacotherapy of fibromyalgia syndrome includes medications that inhibit pronociceptive input and augment modulatory signaling.
“Effective pharmacotherapy of FMS includes medications that inhibit pronociceptive input and augment modulatory signaling.”
From Comparative Efficacy and Harms of Duloxetine, Milnacipran, and Pregabalin in Fibromyalgia Syndrome (2010) · cites this paper as [69]
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- Authors
- Wood, P. B., Holman, A. J., & Jones, K. D.
- Affiliations
- Louisiana State University Health Sciences Center Shreveport (US)
- University of Washington (US)
- Oregon Health & Science University (US)
- Venue
- Expert Opinion on Investigational Drugs
- Publisher
- Informa UK Limited
- Published
- 2007-05-15
- Volume
- 16
- Issue
- 6
- Pages
- 829-841
- ISSN
- 1354-3784 (ISSN-L)
- 1744-7658
- OpenAlex
- W2171524367
- Cited by
- 30
- References
- 105
- Citations by year
- 2025: 1 · 2024: 2 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 5
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Investigational Drugs (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- fibromyalgia, pharmacotherapy, chronic widespread pain, pathophysiology, fatigue, sleep disorders, drug mechanisms, new drugs
- MeSH terms
- Analgesics, Opioid, Cannabinoids, Fibromyalgia, Humans, Hypnotics and Sedatives, Pain, Serotonin Antagonists, Neurotransmitter Uptake Inhibitors, Calcium Channels, Dopamine Agonists, Human Growth Hormone
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