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Cerebrovascular Pathology and Dementia in Autopsied Honolulu‐Asia Aging Study Participants
Abstract
A bstract: Clinicopathologic data from 285 autopsies were analyzed. The decedents were long‐standing participants in the Honolulu‐Asia Aging Study, a prospective epidemiologic investigation of stroke, neurodegenerative diseases, and aging. We assessed the prevalence at death of four primary neuropathologic processes using specific microscopic lesions as indicators. An algorithm was developed to assign each decedent to one of six subsets, corresponding to pathologic dominance by microvascular lesions (14% of decedents), Alzheimer lesions (12%), hippocampal sclerosis (5%), cortical Lewy bodies (5%), codominance by two or more primary processes (9%), or without a dominant pathologic process recognized (55%). Definite or probable dementia had been identified in 118 of the decedents. The proportions of men in each subset identified as demented were (in the same order) 57%, 53%, 79%, 57%, 76%, and 25%. In this autopsied panel of older Japanese‐American men, the importance of microvascular lesions as a likely explanation for dementia was nearly equal to that of Alzheimer lesions. The cerebrovascular lesion type most essentially and inclusively related to dementia was multiple microinfarction.
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“However, among these forms of VBI, increased CMIs are most strongly and independently associated with increased risk of dementia.18, 19”
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Metadata
- Authors
- WHITE, L., PETROVITCH, H., HARDMAN, J., NELSON, J., DAVIS, D. G., ROSS, G. W., MASAKI, K., LAUNER, L., & MARKESBERY, W. R.
- Affiliations
- University of Hawaiʻi at Mānoa (US)
- University of Kentucky (US)
- United States Department of Veterans Affairs (US)
- National Institutes of Health (US)
- Corresponding author
- WHITE, LON
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2002-11
- Volume
- 977
- Issue
- 1
- Pages
- 9-23
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2072753569
- Cited by
- 357
- References
- 14
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 4 · 2023: 7 · 2022: 12 · 2021: 14 · 2020: 10 · 2019: 7 · 2018: 15 · 2017: 19 · 2016: 25 · 2015: 12 · 2014: 18 · 2013: 16 · 2012: 35
- FWCI
- 7.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01ag042149-007)
- National Institute on Aging (N01‐AG‐4‐2149)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Cerebrovascular and genetic disorders
- Keywords
- cerebrovascular pathology, dementia, microvascular lesions, hippocampal sclerosis, cortical Lewy bodies, sex differences in dementia, Honolulu-Asia Aging Study, aging
- MeSH terms
- Aged, Alzheimer Disease, Asia, Autopsy, Brain, Cerebral Infarction, Cerebrovascular Circulation, Dementia, Female, Hawaii, Humans, Male, Microcirculation, Prospective Studies, Lewy Bodies, Amoxicillin-Potassium Clavulanate Combination
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