Cited by 357Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsCerebrovascular and genetic disorders

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Cerebrovascular Pathology and Dementia in Autopsied Honolulu‐Asia Aging Study Participants

WHITE, LON, PETROVITCH, HELEN, HARDMAN, JOHN, NELSON, JAMES, DAVIS, DARON G., ROSS, G. WEBSTER, MASAKI, KAMAL, LAUNER, LENORE, MARKESBERY, WILLIAM R.·2002·Annals of the New York Academy of Sciences

DOI 10.1111/j.1749-6632.2002.tb04794.x

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Abstract

A bstract: Clinicopathologic data from 285 autopsies were analyzed. The decedents were long‐standing participants in the Honolulu‐Asia Aging Study, a prospective epidemiologic investigation of stroke, neurodegenerative diseases, and aging. We assessed the prevalence at death of four primary neuropathologic processes using specific microscopic lesions as indicators. An algorithm was developed to assign each decedent to one of six subsets, corresponding to pathologic dominance by microvascular lesions (14% of decedents), Alzheimer lesions (12%), hippocampal sclerosis (5%), cortical Lewy bodies (5%), codominance by two or more primary processes (9%), or without a dominant pathologic process recognized (55%). Definite or probable dementia had been identified in 118 of the decedents. The proportions of men in each subset identified as demented were (in the same order) 57%, 53%, 79%, 57%, 76%, and 25%. In this autopsied panel of older Japanese‐American men, the importance of microvascular lesions as a likely explanation for dementia was nearly equal to that of Alzheimer lesions. The cerebrovascular lesion type most essentially and inclusively related to dementia was multiple microinfarction.

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Authors: WHITE, L., PETROVITCH, H., HARDMAN, J., NELSON, J., DAVIS, D. G., ROSS, G. W., MASAKI, K., LAUNER, L., & MARKESBERY, W. R.
Affiliations: University of Hawaiʻi at Mānoa (US)
University of Kentucky (US)
United States Department of Veterans Affairs (US)
National Institutes of Health (US)
Corresponding author: WHITE, LON
ORCID: WHITE, LON
PETROVITCH, HELEN
MASAKI, KAMAL
LAUNER, LENORE
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2002-11
Volume: 977
Issue: 1
Pages: 9-23
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/j.1749-6632.2002.tb04794.x
OpenAlex: W2072753569
Cited by: 357
References: 14
Citations by year: 2026: 5 · 2025: 10 · 2024: 4 · 2023: 7 · 2022: 12 · 2021: 14 · 2020: 10 · 2019: 7 · 2018: 15 · 2017: 19 · 2016: 25 · 2015: 12 · 2014: 18 · 2013: 16 · 2012: 35
FWCI: 7.39
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1180 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01ag042149-007)
National Institute on Aging (N01‐AG‐4‐2149)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Health Sciences › Medicine › Clinical Neurology › Cerebrovascular and genetic disorders
Keywords: cerebrovascular pathology, dementia, microvascular lesions, hippocampal sclerosis, cortical Lewy bodies, sex differences in dementia, Honolulu-Asia Aging Study, aging
MeSH terms: Aged, Alzheimer Disease, Asia, Autopsy, Brain, Cerebral Infarction, Cerebrovascular Circulation, Dementia, Female, Hawaii, Humans, Male, Microcirculation, Prospective Studies, Lewy Bodies, Amoxicillin-Potassium Clavulanate Combination

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Cerebrovascular Pathology and Dementia in Autopsied Honolulu‐Asia Aging Study Participants

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