The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Inflammation and Liver Cancer: New Molecular Links
Abstract
A connection between inflammation and cancer has been long suspected. Epidemiological studies have established that many tumors occur in association with chronic infectious diseases, and it is also known that persistent inflammation in the absence of infections increases the risk and accelerates the development of cancer. One clear example of inflammation‐related cancer is hepatocellular carcinoma (HCC). HCC is a type tumor that slowly unfolds on a background of chronic inflammation mainly triggered by exposure to infectious agents (hepatotropic viruses) or to toxic compounds (ethanol). The molecular links that connect inflammation and cancer are not completely known, but evidences gathered over the past few years are beginning to define the precise mechanisms. In this article we review the most compelling evidences on the role of transcription factors such as NF‐κB and STAT3, cytokines like IL‐6 and IL‐1α, ligands of the EGF receptor and other inflammatory mediators in cancer development, with special emphasis in HCC. The molecular dissection of the pathways connecting the inflammatory reaction and neoplasia will pave the way for better therapies to treat cancers.
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1 retracted
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Inflammation and cancer: back to Virchow?
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Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
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IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
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NF-κB functions as a tumour promoter in inflammation-associated cancer
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The Lifelong Effects of Early Childhood Adversity and Toxic Stress
Shonkoff, J. P., Garner, A. S., THE COMMITTEE ON PSYCHOSOCIAL ASPECTS OF CHILD AND FAMILY HEALTH, C. O. E. C., Siegel, B. S., Dobbins, M. I., Earls, M. F., Garner, A. S., McGuinn, L., Pascoe, J., & Wood, D. L. (2012) · Pediatrics · doi:10.1542/peds.2011-2663 · Cited by 5,164
Reactive oxygen species in cancer
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Tang, W., Chen, Z., Zhang, W., Cheng, Y., Zhang, B., Wu, F., Wang, Q., Wang, S., Rong, D., Reiter, F. P., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0187-x · Cited by 997
He, G., Yu, G.-Y., Temkin, V., Ogata, H., Kuntzen, C., Sakurai, T., Sieghart, W., Peck-Radosavljevic, M., Leffert, H. L., & Karin, M. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.048 · Cited by 427
Capece, D., Fischietti, M., Verzella, D., Gaggiano, A., Cicciarelli, G., Tessitore, A., Zazzeroni, F., & Alesse, E. (2013) · BioMed Research International · doi:10.1155/2013/187204 · Cited by 408
Metadata
- Authors
- Berasain, C., Castillo, J., Perugorria, M. J., Latasa, M. U., Prieto, J., & Avila, M. A.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2009-02
- Volume
- 1155
- Issue
- 1
- Pages
- 206-221
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1942321192
- Cited by
- 390
- References
- 107
- FWCI
- 19.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Berasain, C., Castillo, J., Perugorria, M. J., Latasa, M. U., Prieto, J., & Avila, M. A. (2009). Inflammation and Liver Cancer: New Molecular Links. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.2009.03704.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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