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Cited by 181

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Glucocorticoids: Mood, Memory, and Mechanisms

Wolkowitz, Owen M., Burke, Heather, Epel, Elissa S., Reus, Victor I.·2009·Annals of the New York Academy of Sciences
DOI 10.1111/j.1749-6632.2009.04980.x
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Abstract

Elevated circulating levels of glucocorticoids are associated with psychiatric symptoms across several different conditions. It remains unknown if this hormonal abnormality is a cause or an effect of the psychiatric conditions. For example, the hypercortisolemia observed in a subset of patients with depression may have a direct impact on the symptoms of depression, but it is also possible that the hypercortisolemia merely reflects the stress associated with depression. Further, rather than causing depression, hypercortisolemia could represent a homeostatic attempt to overcome glucocorticoid resistance. Each of these possibilities will be considered, and correlational and causal evidence will be reviewed. This article will focus on the relationships between glucocorticoids and psychiatric symptoms in Cushing's syndrome, major depression, and steroid psychosis/steroid dementia, as well as the effects of exogenously administered glucocorticoids in normal volunteers. Similarities and differences in the relationship of glucocorticoid hormones to psychiatric symptoms in these conditions will be reviewed. Possible mediators of glucocorticoid effects on the brain and behavior, as well as possible “pro‐aging” effects of glucocorticoids in certain cells of the body, will be reviewed. The article concludes with a conceptual model of glucocorticoid actions in the brain that may lead to novel therapeutic opportunities.

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Metadata

Authors
Wolkowitz, O. M., Burke, H., Epel, E. S., & Reus, V. I.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2009-10
Volume
1179
Issue
1
Pages
19-40
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/j.1749-6632.2009.04980.x
OpenAlex
W2329166121
Cited by
181
References
41
FWCI
4.47
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Glucocorticoids: Mood, Memory, and Mechanisms. https://app.cochat.ai/papers/10.1111/j.1749-6632.2009.04980.x
The paper
Wolkowitz, O. M., Burke, H., Epel, E. S., & Reus, V. I. (2009). Glucocorticoids: Mood, Memory, and Mechanisms. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.2009.04980.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.