How might circadian rhythms control mood? Let me count the ways

McClung, Colleen A.

doi:10.1016/j.biopsych.2013.02.019

Cited by 507Circadian rhythm and melatoninSleep and Wakefulness ResearchStress Responses and Cortisol

How might circadian rhythms control mood? Let me count the ways

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McClung, Colleen A.·2013·Biological Psychiatry

DOI 10.1016/j.biopsych.2013.02.019PMC PMC3725187

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Abstract

Mood disorders are serious diseases that affect a large portion of the population. There have been many hypotheses put forth over the years to explain the development of major depression, bipolar disorder, and other mood disorders. These hypotheses include disruptions in monoamine transmission, hypothalamus-pituitary-adrenal axis function, immune function, neurogenesis, mitochondrial dysfunction, and neuropeptide signaling (to name a few). Nearly all people suffering from mood disorders have significant disruptions in circadian rhythms and the sleep/wake cycle. In fact, altered sleep patterns are one of the major diagnostic criteria for these disorders. Moreover, environmental disruptions to circadian rhythms, including shift work, travel across time zones, and irregular social schedules, tend to precipitate or exacerbate mood-related episodes. Recent studies have found that molecular clocks are found throughout the brain and body where they participate in the regulation of most physiological processes, including those thought to be involved in mood regulation. This review will summarize recent data that implicate the circadian system as a vital regulator of a variety of systems that are thought to play a role in the development of mood disorders.

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Recent work on circadian factors influencing risk of affective disorders has revealed extensive interactions between key emotion regulatory neurotransmitters such as dopamine and the genes controlling the molecular circadian clock.
“Recent work on circadian factors influencing risk of affective disorders have revealed extensive interactions between key emotion regulatory neurotransmitters such as dopamine and the genes controlling the molecular circadian clock (McClung, 2007(McClung, , 2011(McClung, , 2013)).”
From Physiological feelings (2019) · cites this paper as McClung, 2013
A major component of many mood, anxiety and psychotic disorders is a disrupted sleep-wake cycle.
“A major component of many mood, anxiety and psychotic disorders is a disrupted sleep–wake cycle183–188”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [184]

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Authors: McClung, C. A.
Affiliations: University of Pittsburgh (US)
Corresponding author: McClung, Colleen A.
ORCID: McClung, Colleen A.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2013-08
Volume: 74
Issue: 4
Pages: 242-249
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2013.02.019
PMC: PMC3725187
OpenAlex: W2006352405
Cited by: 507
References: 103
Citations by year: 2026: 30 · 2025: 38 · 2024: 27 · 2023: 26 · 2022: 56 · 2021: 41 · 2020: 38 · 2019: 47 · 2018: 41 · 2017: 35 · 2016: 39 · 2015: 45 · 2014: 35 · 2013: 9
FWCI: 5.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH082876, MH082876)
National Institute on Drug Abuse (R01DA023988, DA023988)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: circadian rhythm, mood disorders, major depressive disorder, bipolar disorder, sleep disruption, molecular clock, hypothalamic-pituitary-adrenal axis, immune function, neurogenesis, mitochondrial dysfunction, neuropeptide signaling, shift work, jet lag
MeSH terms: Biological Clocks, Brain, Circadian Rhythm, Humans, Mood Disorders

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