A knockout mouse resource for the biomedical research community
Open accessAbstract
The Knockout Mouse Project (KOMP) Repository archives and distributes vectors, embryonic stem cell clones, frozen germplasm, and live mutant mice for 8,500 knockout genes. Here, we describe the creation and functions of the KOMP Repository.
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Efforts to probe clinical consequences of coding alleles with large phenotypic effects, particularly null alleles, in humans and animal models represent powerful strategies for extending functional analyses to the whole-body level.
“Efforts to probe the clinical consequences of coding alleles with large phenotypic effects (particularly null alleles) in humans53,54 and across diverse animal models116 represent powerful strategies for extending functional analyses to the whole-body level.”
From A brief history of human disease genetics (2020) · cites this paper as [116]
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Cites
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187 · see citing works
A conditional knockout resource for the genome-wide study of mouse gene function
Skarnes, W. C., Rosen, B., West, A. P., Koutsourakis, M., Bushell, W., Iyer, V., Mujica, A. O., Thomas, M., Harrow, J., Cox, T., et al. (2011) · Nature · doi:10.1038/nature10163 · Cited by 1,708 · see citing works
The Comprehensive Knockout Mouse Project Consortium (2004) · Nature Genetics · doi:10.1038/ng0904-921 · Cited by 608 · see citing works
Collins, F. S. (2007) · Cell · doi:10.1016/j.cell.2006.12.018 · Cited by 412 · see citing works
The European dimension for the mouse genome mutagenesis program
Auwerx, J. H., Avner, P. R., Chambon, P., Baldock, R., Davidson, D. R., Hastie, N. D., Jackson, I. J., Ballabio, A., Balling, R., Barbacid, M., et al. (2004) · Nature Genetics · doi:10.1038/ng0904-925 · Cited by 197 · see citing works
Tools for targeted manipulation of the mouse genome.
van der Weyden, L., Adams, D., & Bradley, A. (2002) · Physiological Genomics · doi:10.1152/physiolgenomics.00074.2002 · Cited by 197 · see citing works
Mouse project to find each gene's role
Abbott, A. (2010) · Nature · doi:10.1038/465410a · Cited by 35 · see citing works
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A brief history of human disease genetics
Claussnitzer, M., Cho, J. H., Collins, R., Cox, N. J., Dermitzakis, E. T., Hurles, M. E., Kathiresan, S., Kenny, E. E., Lindgren, C. M., MacArthur, D. G., et al. (2020) · Nature · doi:10.1038/s41586-019-1879-7 · Cited by 697 · see citing works
Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development
Ngan, C. Y., Wong, C. H., Tjong, H., Wang, W., Goldfeder, R. L., Choi, C., He, H., Gong, L., Lin, J., Urban, B., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-0581-x · Cited by 140 · see citing works
- Authors
- Lloyd, K. C. K.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Lloyd, K. C. Kent
- ORCID
- Lloyd, K. C. Kent
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2011-12
- Volume
- 1245
- Issue
- 1
- Pages
- 24-26
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- PMC
- PMC4070945
- OpenAlex
- W1586688941
- Cited by
- 70
- References
- 7
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 9 · 2015: 8 · 2013: 9 · 2012: 3
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (U42OD011175, UM1OD023221)
- National Human Genome Research Institute (U54HG006364)
- National Cancer Institute (P30CA093373)
- National Center for Research Resources (U42RR024244, U42RR033193)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- knockout mice, germplasm distribution, gene targeting vectors
- MeSH terms
- Animals, Animal Husbandry, California, Genetic Engineering, Biological Specimen Banks, Mice, Knockout, Mice, Embryonic Stem Cells
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