The knockout mouse project

Initial sequencing and analysis of the human genome

International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216 · see citing works

The sequence of the human genome

Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909 · see citing works

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works

Initial sequencing and comparative analysis of the mouse genome

Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187 · see citing works

A protein related to extracellular matrix proteins deleted in the mouse mutant reeler

D'Arcangelo, G., G. Miao, G., Chen, S.-C., Scares, H. D., Morgan, J. I., & Curran, T. (1995) · Nature · doi:10.1038/374719a0 · Cited by 1,748 · see citing works

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

Chen, R. Z., Akbarian, S., Tudor, M., & Jaenisch, R. (2001) · Nature Genetics · doi:10.1038/85906 · Cited by 1,275 · see citing works

Molecular characterization of the mouse agouti locus

Bultman, S. J., Michaud, E. J., & Woychik, R. P. (1992) · Cell · doi:10.1016/s0092-8674(05)80067-4 · Cited by 805 · see citing works

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

Valenzuela, D. M., Murphy, A. J., Frendewey, D. A., Gale, N. W., Economides, A. N., Auerbach, W., Poueymirou, W. T., Adams, N. C., Rojas, J., Yasenchak, J., et al. (2003) · Nature Biotechnology · doi:10.1038/nbt822 · Cited by 585 · see citing works

Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

Zambrowicz, B., Friedrich, G. A., Buxton, E. C., Lilleberg, S. L., Person, C., & Sands, A. (1998) · Nature · doi:10.1038/33423 · Cited by 436 · see citing works

Gene-trap mutagenesis: past, present and beyond

Stanford, W. L., Cohn, J. B., & Cordes, S. P. (2001) · Nature Reviews Genetics · doi:10.1038/35093548 · Cited by 391 · see citing works

Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention

Zambrowicz, B., Abuin, A., Ramírez‐Solis, R., Richter, L. J., Piggott, J. R., BeltrandelRio, H., Buxton, E. C., Edwards, J., Finch, R. A., Friddle, C. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336103100 · Cited by 330 · see citing works

Transgenic RNA interference in ES cell–derived embryos recapitulates a genetic null phenotype

Kunath, T., Gish, G. D., Lickert, H., Jones, N., Pawson, T. J., & Rossant, J. (2003) · Nature Biotechnology · doi:10.1038/nbt813 · Cited by 278 · see citing works

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells

Stryke, D. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg064 · Cited by 239 · see citing works

A public gene trap resource for mouse functional genomics

Skarnes, W. C., Nord, A. S., Cox, T., von Melchner, H., Wurst, W., Hicks, G. G., Young, S. G., Conklin, B. R., Ruiz, P., Soriano, P. M., et al. (2004) · Nature Genetics · doi:10.1038/ng0604-543 · Cited by 208 · see citing works

Mouse models for mitochondrial disease

Wallace, D. C. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1393 · Cited by 178 · see citing works

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome

Hansen, J., Floß, T., Sloun, P. P. H. V., Füchtbauer, E., Vauti, F., Arnold, H.-H., Schnütgen, F., Wurst, W., von Melchner, H., & Ruíz, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1633296100 · Cited by 144 · see citing works

Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation

Eggan, K. C., Rode, A., Jentsch, I., Samuel, C., Hennek, T., Tintrup, H., Zevnik, B., Erwin, J. A., Loring, J. M., Jackson‐Grusby, L., et al. (2002) · Nature Biotechnology · doi:10.1038/nbt0502-455 · Cited by 141 · see citing works

To knockout in 129 or in C57BL/6: that is the question

Seong, E., Saunders, T. L., Stewart, C. L., & Burmeister, M. (2003) · Trends in Genetics · doi:10.1016/j.tig.2003.12.006 · Cited by 141 · see citing works

Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells

Wiles, M. V., Vauti, F., Otte, J., Füchtbauer, E., Ruíz, P., Füchtbauer, A. C., Arnold, H.-H., Lehrach, H. R., Metz, T., von Melchner, H., et al. (2000) · Nature Genetics · doi:10.1038/71622 · Cited by 139 · see citing works

Functional Annotation of Mouse Genome Sequences

Nadeau, J. H., Balling, R., Barsh, G. S., Beier, D. R., Brown, S. D. M., Bućan, M., Camper, S. A., Carlson, G. A., Copeland, N. G., Eppig, J. T., et al. (2001) · Science · doi:10.1126/science.1058244 · Cited by 135 · see citing works

Identification and validation of PDGF transcriptional targets by microarray-coupled gene-trap mutagenesis

Chen, W. V., Delrow, J. J., Corrin, P. D., Frazier, J. P., & Soriano, P. M. (2004) · Nature Genetics · doi:10.1038/ng1306 · Cited by 110 · see citing works

Skeletal development: insights from targeting the mouse genome

Horton, W. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14119-0 · Cited by 68 · see citing works

Laskers for 2001: Knockout mice and test-tube babies

Goldstein, J. L. (2001) · Nature Medicine · doi:10.1038/nm1001-1079 · Cited by 21 · see citing works

Cardiovascular diseases: new insights from knockout mice

DAORLEANSJUSTE, P. (2003) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(03)00017-1 · Cited by 12 · see citing works

Network pharmacology: the next paradigm in drug discovery

Hopkins, A. L. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.118 · Cited by 4,622 · see citing works

The UCSC Genome Browser database: update 2011

Fujita, P. A., Rhead, B. L., Zweig, A. S., Hinrichs, A. S., Karolchik, D., Cline, M., Goldman, M. J., Barber, G. P., Clawson, H., Coelho, A., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq963 · Cited by 1,836 · see citing works

The ascent of mouse: advances in modelling human depression and anxiety

Cryan, J. F., & Holmes, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1825 · Cited by 1,198 · see citing works

Charting a course for genomic medicine from base pairs to bedside

Green, E. D., & Guyer, M. S. (2011) · Nature · doi:10.1038/nature09764 · Cited by 901 · see citing works

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivoPreprint

Shim, J., Xiao, C., Paschal, A. E., Bailey, S. T., Rao, P., Hayden, M. S., Lee, K., Bussey, C., Steckel, M., Tanaka, N., et al. (2005) · Genes & Development · doi:10.1101/gad.1360605 · Cited by 735 · see citing works

Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century

Capecchi, M. (2005) · Nature reviews genetics · doi:10.1038/nrg1619 · Cited by 723 · see citing works

Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs

Moran, V. A., Perera, R. J., & Khalil, A. M. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks296 · Cited by 637 · see citing works

Mosaic Analysis with Double Markers in Mice

Zong, H., Espinosa, J. S., Su, H. H., Muzumdar, M. D., & Luo, L. (2005) · Cell · doi:10.1016/j.cell.2005.02.012 · Cited by 586 · see citing works

The UCSC Genome Browser database: update 2010

Rhead, B. L., Karolchik, D., Kuhn, R. M., Hinrichs, A. S., Zweig, A. S., Fujita, P. A., Diekhans, M., Smith, K. E., Rosenbloom, K. R., Raney, B. J., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp939 · Cited by 567 · see citing works

Elevated Plus Maze for Mice

Komada, M., Takao, K., & Miyakawa, T. (2008) · Journal of Visualized Experiments · doi:10.3791/1088 · Cited by 551 · see citing works

Strategies for mapping and cloning quantitative trait genes in rodents

Jonathan Flint, C., Valdar, W. S. J., Shifman, S., & Mott, R. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1576 · Cited by 497 · see citing works

The Mammalian Phenotype Ontology as a tool for annotating, analyzing and comparing phenotypic information

Smith, C. L., Goldsmith, C.-A. W., & Eppig, J. T. (2004) · Genome Biology · doi:10.1186/gb-2004-6-1-r7 · Cited by 417 · see citing works

A Mouse for All Reasons

Collins, F. S. (2007) · Cell · doi:10.1016/j.cell.2006.12.018 · Cited by 412 · see citing works

Genetic architecture of quantitative traits in mice, flies, and humansPreprint

Jonathan Flint, C., & Mackay, T. F. C. (2009) · Genome Research · doi:10.1101/gr.086660.108 · Cited by 404 · see citing works

Schizophrenia-Relevant Behavioral Testing in Rodent Models: A Uniquely Human Disorder?

Powell, C. M., & Miyakawa, T. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.008 · Cited by 368 · see citing works

The mammalian phenotype ontology: enabling robust annotation and comparative analysis

Smith, C. L., & Eppig, J. T. (2009) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.44 · Cited by 353 · see citing works

DMP1-targeted Cre Expression in Odontoblasts and Osteocytes

Lu, Y., Xie, Y., Zhang, S., Dusevich, V., Bonewald, L. F., & Feng, J. Q. (2007) · Journal of Dental Research · doi:10.1177/154405910708600404 · Cited by 350 · see citing works

A mouse knockout library for secreted and transmembrane proteins

Tang, T. T.-L., Li, L., Tang, J., Li, Y., Lin, W., Martin, F., Grant, D., Solloway, M. J., Parker, L. H., Ye, W., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1644 · Cited by 334 · see citing works

The mammalian gene function resource: the international knockout mouse consortium

Bradley, A., Anastassiadis, K., Ayadi, A., Battey, J. F., Bell, C., Birling, M., BOTTOMLEY, J. R., Brown, S. D. M., Bürger, A., Bult, C. J., et al. (2012) · Mammalian Genome · doi:10.1007/s00335-012-9422-2 · Cited by 312 · see citing works

The NCATS BioPlanet – An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics

Huang, R., Grishagin, I. V., Wang, Y., Zhao, T., Greene, J., Obenauer, J. C., Ngan, D. K., Nguyễn, Ð.-T., Guha, R., Jadhav, A., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00445 · Cited by 294 · see citing works

The mouse as a model for human biology: a resource guide for complex trait analysis

Peters, L. L., Robledo, R. F., Bult, C. J., Churchill, G. A., Paigen, B. J., & Svenson, K. L. (2006) · Nature Reviews Genetics · doi:10.1038/nrg2025 · Cited by 283 · see citing works

Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study

Mandillo, S., Tucci, V., Hölter, S. M., Méziane, H., Banchaabouchi, M. A., Kallnik, M., Lad, H. V., Nolan, P. M., Ouagazzal, A., Coghill, E. L., et al. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.90207.2008 · Cited by 286 · see citing works

Emerging and evolving concepts in gene essentiality

Rancati, G. I., Moffat, J., Typas, A., & Pavelka, N. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.74 · Cited by 272 · see citing works

Light/dark Transition Test for Mice

Takao, K., & Miyakawa, T. (2006) · Journal of Visualized Experiments · doi:10.3791/104 · Cited by 268 · see citing works

Developmental and adult phenotyping directly from mutant embryonic stem cells

George, S. H. L., Gertsenstein, M., Vintersten, K., Korets-Smith, E., Murphy, J. T., Stevens, M. E., Haigh, J. J., & Nagy, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609277104 · Cited by 267 · see citing works

Utilizing RNA interference to enhance cancer drug discovery

Iorns, E. J., Lord, C. J., Turner, N. C., & Ashworth, A. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2355 · Cited by 251 · see citing works

Null mutations in human and mouse orthologs frequently result in different phenotypes

Liao, B.-Y., & Zhang, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800387105 · Cited by 234 · see citing works

Mendelian disorders deserve more attention

Antonarakis, S. E., & Beckmann, J. S. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1826 · Cited by 241 · see citing works

F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses

Poueymirou, W. T., Auerbach, W., Frendewey, D. A., Hickey, J. F., Escaravage, J. M., Esau, L., Dore, A. T., Stevens, S. G., Adams, N. C., Dominguez, M. G., et al. (2006) · Nature Biotechnology · doi:10.1038/nbt1263 · Cited by 238 · see citing works

Responsible Conduct of Research

Shamoo, A. E., & Resnik, D. B. (2022) · doi:10.1093/oso/9780197547090.001.0001 · Cited by 224 · see citing works

Learning from Small Fry: The Zebrafish as a Genetic Model Organism for Aquaculture Fish Species

Dahm, R., & Geisler, R. (2006) · Marine Biotechnology · doi:10.1007/s10126-006-5139-0 · Cited by 223 · see citing works

Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities

Li, Z., Yu, T., Morishima, M., Pao, A., LaDuca, J., Conroy, J., Nowak, N., Matsui, S.-I., Shiraishi, I., & Yu, Y. E. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm086 · Cited by 218 · see citing works

Cyto- and chemoarchitecture of the hypothalamic paraventricular nucleus in the C57BL/6J male mouse: a study of immunostaining and multiple fluorescent tract tracing

Biag, J., Huang, Y., Gou, L., Hintiryan, H., Askarinam, A., Hahn, J. D., Toga, A. W., & Dong, H. (2012) · Journal of Comparative Neurology · doi:10.1002/cne.22698 · Cited by 205 · see citing works

Involvement of Ca2+-Dependent Hyperpolarization in Sleep Duration in Mammals

Tatsuki, F., Sunagawa, G. A., Shi, S., Susaki, E. A., Yukinaga, H., Perrin, D., Sumiyama, K., Ukai‐Tadenuma, M., Fujishima, H., Ohno, R.-I., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.032 · Cited by 196 · see citing works

The European dimension for the mouse genome mutagenesis program

Auwerx, J. H., Avner, P. R., Chambon, P., Baldock, R., Davidson, D. R., Hastie, N. D., Jackson, I. J., Ballabio, A., Balling, R., Barbacid, M., et al. (2004) · Nature Genetics · doi:10.1038/ng0904-925 · Cited by 197 · see citing works

Appearances can be deceiving: phenotypes of knockout mice

Barbaric, I., Miller, G., & Dear, T. N. (2007) · Briefings in Functional Genomics and Proteomics · doi:10.1093/bfgp/elm008 · Cited by 195 · see citing works

Male infertility caused by spermiogenic defects: Lessons from gene knockouts

Yan, W. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.03.003 · Cited by 194 · see citing works

Elevated Plus Maze for Mice

Komada, M., Takao, K., & Miyakawa, T. (2008) · Journal of Visualized Experiments · doi:10.3791/1088-v · Cited by 193 · see citing works

Introducing the German Mouse Clinic: open access platform for standardized phenotyping

Gailus‐Durner, V., Fuchs, H., Becker, L., Bolle, I., Brielmeier, M., Calzada‐Wack, J., Elvert, R., Ehrhardt, N. M., Dalke, C., Franz, T. J., et al. (2005) · Nature Methods · doi:10.1038/nmeth0605-403 · Cited by 191 · see citing works

Animal models of depression

Deussing, J. M. (2006) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2006.11.003 · Cited by 190 · see citing works

High‐throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains

Philip, V. M., Duvvuru, S., Gomero, B., Ansah, T.-A., Blaha, C. D., Cook, M. N., Hamre, K. M., Lariviere, W. R., Matthews, D. B., Mittleman, G., et al. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00540.x · Cited by 186 · see citing works

Virtual Histology of Transgenic Mouse Embryos for High-Throughput Phenotyping

Johnson, J. T., Hansen, M. S., Wu, I. Q., Healy, L., Johnson, C. R., Jones, G., Capecchi, M. R., & Keller, C. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020061 · Cited by 183 · see citing works

Pancreas-specific Cre driver lines and considerations for their prudent use

Magnuson, M., & Osipovich, A. B. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.011 · Cited by 188 · see citing works

A Resource for the Conditional Ablation of microRNAs in the Mouse

Park, C. Y., Jeker, L. T., Carver-Moore, K., Oh, A., Liu, H. J., Cameron, R., Richards, H. W., Li, Z., Adler, D., Yoshinaga, Y., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.02.008 · Cited by 174 · see citing works

Linking RNA biology to lncRNAsPreprint

Goff, L. A., & Rinn, J. L. (2015) · Genome Research · doi:10.1101/gr.191122.115 · Cited by 175 · see citing works

Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain

Goff, L. A., Groff, A. F., Sauvageau, M., Trayes-Gibson, Z., Sanchez-Gomez, D. B., Morse, M., Martin, R., Elcavage, L. E., Liapis, S. C., Gonzalez-Celeiro, M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411263112 · Cited by 174 · see citing works

The Mammalian Phenotype Ontology as a unifying standard for experimental and high-throughput phenotyping data

Smith, C. L., & Eppig, J. T. (2012) · Mammalian Genome · doi:10.1007/s00335-012-9421-3 · Cited by 174 · see citing works

Reduced Glutathione Enhances Fertility of Frozen/Thawed C57BL/6 Mouse Sperm after Exposure to Methyl-Beta-Cyclodextrin1

Takeo, T., & Nakagata, N. (2011) · Biology of Reproduction · doi:10.1095/biolreprod.111.092536 · Cited by 169 · see citing works

Genomewide production of multipurpose alleles for the functional analysis of the mouse genome

Schnütgen, F., De-Zolt, S., Sloun, P. P. H. V., Hollatz, M., Floß, T., Hansen, J., Altschmied, J., Seisenberger, C., Ghyselinck, N. B., Ruíz, P., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502273102 · Cited by 167 · see citing works

Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice

Berghe, T. V., Hulpiau, P., Martens, L., Vandenbroucke, R. E., Wonterghem, E. V., Perry, S. W., Bruggeman, I., Divert, T., Choi, S. M., Vuylsteke, M., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.011 · Cited by 165 · see citing works

EMPReSS: standardized phenotype screens for functional annotation of the mouse genome

Brown, S. D. M., Chambon, P., & de Angelis, M. H. (2005) · Nature Genetics · doi:10.1038/ng1105-1155 · Cited by 159 · see citing works

Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project

Ayadi, A., Birling, M., BOTTOMLEY, J. R., Bussell, J., Fuchs, H., Fray, M., Gailus‐Durner, V., Greenaway, S., Houghton, R., Karp, N. A., et al. (2012) · Mammalian Genome · doi:10.1007/s00335-012-9418-y · Cited by 155 · see citing works

Assignment of protein function in the postgenomic era

Saghatelian, A., & Cravatt, B. F. (2005) · Nature Chemical Biology · doi:10.1038/nchembio0805-130 · Cited by 155 · see citing works

Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells

Kanatsu‐Shinohara, M., Ikawa, M., Takehashi, M., Ogonuki, N., Miki, H., Inoue, K., Kazuki, Y., Lee, J., Toyokuni, S., Oshimura, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601139103 · Cited by 150 · see citing works

‘One medicine—one pathology': are veterinary and human pathology prepared?

Cardiff, R. D., Ward, J. M., & Barthold, S. W. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700695 · Cited by 150 · see citing works

Integrative Physiology: At the Crossroads of Nutrition, Microbiota, Animal Physiology, and Human Health

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Current issues in mouse genome engineering

Glaser, S., Anastassiadis, K., & Stewart, A. F. (2005) · Nature Genetics · doi:10.1038/ng1668 · Cited by 160 · see citing works

Chemical control of stem cell fate and developmental potential.

Lyssiotis, C., Lairson, L., Boitano, A. E., Wurdak, H., Zhu, S.-T., & Schultz, P. (2011) · Angewandte Chemie · doi:10.1002/anie.201004284 · Cited by 167 · see citing works

GeneWeaver: a web-based system for integrative functional genomics

Baker, E. J., Jay, J. J., Bubier, J. A., Langston, M. A., & Chesler, E. J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr968 · Cited by 140 · see citing works

Toward simpler and faster genome-wide mutagenesis in mice

Wu, S., Ying, G., Wu, Q., & Capecchi, M. R. (2007) · Nature Genetics · doi:10.1038/ng2060 · Cited by 140 · see citing works

A protocol for constructing gene targeting vectors: generating knockout mice for the cadherin family and beyond

Wu, S., Ying, G., Wu, Q., & Capecchi, M. R. (2008) · Nature Protocols · doi:10.1038/nprot.2008.70 · Cited by 133 · see citing works

Identification of cardiac malformations in mice lacking Ptdsrusing a novel high-throughput magnetic resonance imaging technique

Schneider, J. E., Böse, J., Bamforth, S. D., Gruber, A. D., Broadbent, C., Clarke, K. J., Neubauer, S., Lengeling, A., & Bhattacharya, S. (2004) · BMC Developmental Biology · doi:10.1186/1471-213x-4-16 · Cited by 136 · see citing works

Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology

Aspatwar, A., Tolvanen, M. E. E., Barker, H. R., Syrjänen, L., Valanne, S., Purmonen, S., Waheed, A., Sly, W. S., & Parkkila, S. (2022) · Physiological Reviews · doi:10.1152/physrev.00018.2021 · Cited by 135 · see citing works

The blessings and curses of C57BL/6 substrains in mouse genetic studies

Bryant, C. D. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06325.x · Cited by 139 · see citing works

The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse

Nord, A. S. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj097 · Cited by 132 · see citing works

A review of current large‐scale mouse knockout efforts

Guan, C., Ye, C., Yang, X., & Gao, J. (2010) · genesis · doi:10.1002/dvg.20594 · Cited by 129 · see citing works

A recombineering based approach for high-throughput conditional knockout targeting vector construction

Chan, W., Costantino, N., Li, R., Lee, S. C., Su, Q., Melvin, D., Court, D. L., & Liu, P. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm163 · Cited by 125 · see citing works

EUCOMM the European Conditional Mouse Mutagenesis Program

Friedel, R. H., Seisenberger, C., Kaloff, C., & Wurst, W. (2007) · Briefings in Functional Genomics and Proteomics · doi:10.1093/bfgp/elm022 · Cited by 126 · see citing works

Mouse models in male fertility research

Jamsai, D., & O’Bryan, M. K. (2010) · Asian Journal of Andrology · doi:10.1038/aja.2010.101 · Cited by 123 · see citing works

Granulin epithelin precursor: a bone morphogenic protein 2‐inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis

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Large-scale gene trapping in C57BL/6N mouse embryonic stem cellsPreprint

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