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Cited by 571

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Obesity and cancer risk: evidence, mechanisms, and recommendations

Open access
Vucenik, Ivana, Stains, Joseph P.·2012·Annals of the New York Academy of Sciences
DOI 10.1111/j.1749-6632.2012.06750.x
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Abstract

Obesity, a growing health problem worldwide, has been associated with the metabolic syndrome, diabetes, cardiovascular disease, hypertension, and other chronic diseases. Recently, the obesity–cancer link has received much attention. Epidemiological studies have shown that obesity is also associated with increased risk of several cancer types, including colon, breast, endometrium, liver, kidney, esophagus, gastric, pancreatic, gallbladder, and leukemia, and can also lead to poorer treatment and increased cancer‐related mortality. Biological mechanisms underlying the relationship between obesity and cancer are not well understood. They include modulation of energy balance and calorie restriction, growth factors, multiple signaling pathways, and inflammatory processes. Key among the signaling pathways linking obesity and cancer is the PI3K/Akt/mTOR cascade, which is a target of many of the obesity‐associated factors and regulates cell proliferation and survival. Understanding the molecular and cellular mechanisms of the obesity–cancer connection is important in developing potential therapeutics. The link between obesity and cancer underscores the recommendation to maintain a healthy body weight throughout life as one of the most important ways to protect against cancer.

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Metadata

Authors
Vucenik, I., & Stains, J. P.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2012-10
Volume
1271
Issue
1
Pages
37-43
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/j.1749-6632.2012.06750.x
OpenAlex
W1892385952
Cited by
571
References
58
FWCI
24.00
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Obesity and cancer risk: evidence, mechanisms, and recommendations. https://app.cochat.ai/papers/10.1111/j.1749-6632.2012.06750.x
The paper
Vucenik, I., & Stains, J. P. (2012). Obesity and cancer risk: evidence, mechanisms, and recommendations. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.2012.06750.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.