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Cited by 43Neuroinflammation and Neurodegeneration MechanismsHIV Research and TreatmentInfectious Diseases and Tuberculosis

CD45 Isoform Expression in Microglia and Inflammatory Cells in HIV‐1 Encephalitis

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Cosenza‐Nashat, Melissa A., Kim, Mee‐Ohk, Zhao, Meng‐Liang, Suh, Hyeon‐Sook, Lee, Sunhee C.·2006·Brain Pathology
DOI 10.1111/j.1750-3639.2006.00027.xPMC PMC1804203
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Abstract

CD45 is a membrane tyrosine phosphatase that modulates the function of the hematopoietic cells.In vitro, agonist antibodies to CD45RO or CD45RB isoforms have been shown to suppress microglial activation, but whether microglia in vivo express these isoforms in HIV encephalitis (HIVE) is unknown. Brain sections from control and HIVE were immunostained for CD45 isoforms using exon‐specific antibodies (RA, RB, RC and RO). RA and RC were limited to rare lymphocytes, while RB expression was robust in microglia and inflammatory cells. RO was low in control microglia, but increased in HIVE. RO was also localized to macrophages and CD8+ T cells. Targeting CD45 in vivo with isoform‐specific antibodies remains a therapeutic option for neuroinflammatory diseases.

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Cited by

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Authors
Cosenza‐Nashat, M. A., Kim, M., Zhao, M., Suh, H., & Lee, S. C.
Affiliations
  • Massachusetts General Hospital (US)
  • Albert Einstein College of Medicine (US)
Corresponding author
Lee, Sunhee C.
Venue
Brain Pathology
Publisher
Wiley
Published
2006-10
Volume
16
Issue
4
Pages
256-265
ISSN
  • 1015-6305 (ISSN-L)
  • 1750-3639
DOI
10.1111/j.1750-3639.2006.00027.x
PMC
PMC1804203
OpenAlex
W2093204054
Cited by
43
References
5
Citations by year
2026: 2 · 2025: 1 · 2024: 6 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 5 · 2012: 2
FWCI
0.88
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 45 d)
Locations
  • Brain Pathology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (AI0-51519)
  • National Institute of Mental Health (R01MH055477, U01MH083545, R01 MH 55477, R24-MH-59724, R24MH059724)
  • National Institute of Allergy and Infectious Diseases (P30AI051519, AI 051519)
  • National Institute of Neurological Disorders and Stroke (T32NS007098, NS 07098)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
Keywords
CD45 isoforms, CD45RO, CD45RB, CD45RA, CD45RC, HIV-1 encephalitis, microglia, neuroinflammation, CD8+ T cells, macrophages
MeSH terms
Brain, Humans, Immunohistochemistry, Lymphocytes, Macrophages, Middle Aged, HIV-1, AIDS Dementia Complex, Leukocyte Common Antigens, Microglia, Protein Isoforms

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