Oral cobalamin (vitamin B12) treatment. An update
Open accessAbstract
The objective of this review was to evaluate oral cobalamin (vitamin B(12)) therapy in adult and elderly patients, from the perspective of a hematologist. PubMed was systematically searched for English and French articles published from January 1990 to January 2007. Data from our working group, the 'Groupe d'étude des carences en vitamine B(12)des Hôpitaux Universitaires de Strasbourg', have also been included. Several prospective studies in well-determined population (n = 4), prospective randomized studies (n = 3) and a systematic review by the Cochrane group (n = 1) provide evidence that oral cobalamin therapy may adequately treat cobalamin deficiency, particularly hematological abnormalities or manifestations. These studies suggest that at least 1000 microg/day of oral cyanocobalmin are needed for pernicious anemia and a mean daily dose of 250 microg for food-cobalamin malabsorption. This present review confirms the previously reported efficacy of oral cobalamin treatment in adult and elderly patients.
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Vitamin B12 is essential for normal brain and nervous system functioning, DNA synthesis, and homocysteine metabolism, and has indirect links to energy metabolism.
“Vitamin B12 (cobalamin) is a water-soluble vitamin essential for normal brain and nervous system functioning, DNA synthesis, and homocysteine metabolism and has indirect links to energy metabolism”
From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [230]
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- Authors
- ANDRÈS, E., DALI‐YOUCEF, N., VOGEL, T., SERRAJ, K., & ZIMMER, J.
- Affiliations
- Hôpitaux Universitaires de Strasbourg (FR)
- Centre de Recherche Public de la Santé (LU)
- Corresponding author
- ANDRÈS, E.
- Venue
- International Journal of Laboratory Hematology
- Publisher
- Wiley
- Published
- 2009-01-11
- Volume
- 31
- Issue
- 1
- Pages
- 1-8
- ISSN
- 1751-5521 (ISSN-L)
- 1751-553X
- OpenAlex
- W1771053245
- Cited by
- 52
- References
- 32
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Laboratory Hematology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Health Sciences › Medicine › Emergency Medicine › Hematological disorders and diagnostics
- Keywords
- vitamin B12 deficiency, vitamin B12, pernicious anemia, hematologic manifestations, elderly patients, treatment efficacy
- MeSH terms
- Clinical Trials as Topic, Humans, Vitamin B 12, Vitamin B 12 Deficiency, Randomized Controlled Trials as Topic
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