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The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Cardiac and Vascular Consequences of Pre‐Hypertension in Youth

Open access
Urbina, Elaine M., Khoury, Philip R., McCoy, Connie, Daniels, Stephen R., Kimball, Thomas R., Dolan, Lawrence M.·2011·The Journal of Clinical Hypertension

Abstract

Hypertension is associated with increased left ventricular mass (LVM) and carotid intima‐media thickness (cIMT), which predict cardiovascular (CV) events in adults. Whether target organ damage is found in pre‐hypertensive youth is not known. The authors measured body mass index, blood pressure, fasting glucose, insulin, lipids and C‐reactive protein, LVM/height 2.7 (LVM index), diastolic function, cIMT, carotid stiffness, augmentation index, brachial artery distensibility, and pulse wave velocity (PWV) in 723 patients aged 10 to 23 years (29% with type 2 diabetes mellitus). Patients were stratified by blood pressure level (normotensive: 531, pre‐hypertensive: 65, hypertensive: 127). Adiposity and CV risk factors worsened across blood pressure group. There was a graded increase in cIMT, arterial stiffness, and LVM index and decrease in diastolic function from normotension to pre‐hypertension to hypertension. In multivariable models adjusted for CV risk factors, status as pre‐hypertension or hypertension remained an independent determinant of target organ damage for LVM, diastolic function, internal cIMT, and carotid and arterial stiffness. Pre‐hypertension is associated with cardiovascular target organ damage in adolescents and young adults. J Clin Hypertens (Greenwich). 2011;13:332–342. ©2011 Wiley Periodicals, Inc.

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Crossref · 10.1111/j.1751-7176.2011.00471.x

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Metadata

Authors
Urbina, E. M., Khoury, P. R., McCoy, C., Daniels, S. R., Kimball, T. R., & Dolan, L. M.
Venue
The Journal of Clinical Hypertension
Publisher
Wiley
Published
2011-04-21
Volume
13
Issue
5
Pages
332-342
ISSN
  • 1524-6175 (ISSN-L)
  • 1751-7176
OpenAlex
W1838167348
Cited by
313
References
5
FWCI
9.23
Type
journal article
Language
en
Open access
bronze

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