Cardiovascular changes during chronic hypertensive states
Open accessAbstract
It is well established that elevated blood pressure constitutes a major risk factor for coronary heart disease, arrythmias, heart failure, cerebrovascular disease, peripheral artery disease and renal failure. Blood pressure level and the duration of arterial hypertension (HTN) impact target organ damage. Many studies in adults have demonstrated the role of antihypertensive therapy in preventing cardiovascular (CV) events. The so-called hard end-points, such as death, myocardial infarction (MI) or stroke, are rarely seen in children, but intermediate target organ damage, including left ventricular hypertrophy, increased intima-media thickness and microalbuminuria, is already detectable during childhood. The goal of antihypertensive treatment is to reduce the global risk of CV events. In the adult population stratification of CV risk is based on blood pressure level, risk factors, subclinical target organ damage and established CV and kidney disease. Increased CV risk begins early in the course of kidney disease, and CV diseases are the most frequent cause of morbidity and mortality in patients with chronic kidney disease (CKD). Children with CKD are especially prone to the long-term effects of CV risk factors, which result in high morbidity and mortality in young adults. To improve the outcome, pediatric and adult CKD patients require nephro- and cardioprotection.
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Hypertension management and treatment is a combination of drug therapy, healthy lifestyle changes, and adherence to treatment.
“Hypertension management and treatment is a combination of drug therapy, healthy lifestyle changes—such as regular physical activity, abstinence from alcohol and narcotics abuse, maintaining a healthy weight, and a low-sodium diet—and adherence to treatment [1, 2, 4, 7].”
From The effect of the mobile “blood pressure management application” on hypertension self-management enhancement: a randomized controlled trial (2021) · cites this paper as [2]
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HYPERTENSION BEYOND BLOOD PRESSURE: AN INTEGRATED DIAGNOSTIC PERSPECTIVE
Karki, V. K., Hirulal, M., Dr. Nisha Biswas, T., & S, P. D. (2026) · International Ayurvedic Medical Journal · doi:10.46607/iamj1314032026
- Authors
- Drozdz, D., & Kawecka-Jaszcz, K.
- Venue
- Pediatric Nephrology
- Published
- 2013-09-12
- Volume
- 29
- Issue
- 9
- Pages
- 1507-1516
- ISSN
- 0931-041X (ISSN-L)
- 1432-198X
- PMC
- PMC4147208
- OpenAlex
- W2085042339
- Cited by
- 72
- References
- 76
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 9 · 2022: 9 · 2021: 14 · 2020: 17 · 2019: 9 · 2018: 6 · 2017: 1 · 2015: 2 · 2014: 1
- FWCI
- 0.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Pediatric Nephrology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion, cc-by-nc-nd)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- chronic hypertension, cardiovascular risk, target organ damage, left ventricular hypertrophy, intima-media thickness, microalbuminuria, chronic kidney disease, pediatric chronic kidney disease, antihypertensive therapy, cardiovascular events, cardiovascular risk stratification, cardiorenal protection
- MeSH terms
- Antihypertensive Agents, Cardiovascular Diseases, Child, Chronic Disease, Humans, Hypertension, Risk Factors, Renal Insufficiency, Chronic
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