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Vitamin D's role in cell proliferation and differentiation: Nutrition Reviews©, Vol. 66, No. s2
Abstract
Vitamin D has pleiotropic effects that go beyond its traditional role in calcium homeostasis. Hundreds of genes with vitamin D receptor response elements directly or indirectly influence cell cycling and proliferation, differentiation, and apoptosis. Vitamin D compounds also have effects on cell function that are nongenomic. The noncalcemic actions of vitamin D influence normal and pathological cell growth, carcinogenesis, immune function, and cardiovascular physiology. This review examines many of the various mechanisms by which vitamin D alters cellular growth and differentiation and explores cell-specific factors that influence responsiveness to vitamin D.
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Cited by
Abramovitch, S., Dahan-Bachar, L., Sharvit, E., Weisman, Y., Tov, A. B., Brazowski, E., & Reif, S. (2011) · Gut · doi:10.1136/gut.2010.234666 · Cited by 286
Vitamin D, Calcium Supplements, and Implications for Cardiovascular Health
Michos, E. D., Cainzos-Achirica, M., Heravi, A. S., & Appel, L. J. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.09.617 · Cited by 94
Miroliaee, A., Nasiri-Toosi, M., Khalilzadeh, O., Esteghamati, A., Abdollahi, A., & Mazloumi, M. (2010) · Hepatology International · doi:10.1007/s12072-010-9194-2 · Cited by 82
Jones, P., Lucock, M., Veysey, M., & Beckett, E. (2018) · Nutrients · doi:10.3390/nu10050554 · Cited by 52
Vitamin D status during normal pregnancy and postpartum. A longitudinal study in 141 Danish women
Milman, N., Hvas, A.-M., & Bergholt, T. (2012) · Journal of Perinatal Medicine · doi:10.1515/jpm.2011.120 · Cited by 51
Vitamin D derivatives enhance cytotoxic effects of H2O2 or cisplatin on human keratinocytes
Piotrowska, A., Wierzbicka, J., Ślebioda, T., Woźniak, M., Tuckey, R. C., Slominski, A. T., & Żmijewski, M. A. (2016) · Steroids · doi:10.1016/j.steroids.2016.04.002 · Cited by 48
Metadata
- Authors
- Samuel, S., & Sitrin, M. D.
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-09-25
- Volume
- 66
- Issue
- 10 Suppl 2
- Pages
- S116-S124
- ISSN
- 0029-6643 (ISSN-L)
- OpenAlex
- W2127675927
- Cited by
- 336
- References
- 0
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- closed
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