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1,25-Dihydroxyvitamin D 3 Induces Nitric Oxide Synthase and Suppresses Growth of Mycobacterium tuberculosis in a Human Macrophage-Like Cell Line

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Novel activities of CYP11A1 and their potential physiological significance

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Cytochromes P450 are essential players in the vitamin D signaling system

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Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase

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RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20‐hydroxy‐ and 20,23‐dihydroxyvitamin D

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<i>In vivo</i> evidence for a novel pathway of vitamin D ₃ metabolism initiated by P450scc and modified by CYP27B1

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Vitamin D: A D-Lightful Solution for Health

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Calcium and vitamin D supplements and health outcomes: a reanalysis of the Women’s Health Initiative (WHI) limited-access data set

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A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin

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Vitamin D Protects Human Endothelial Cells From Oxidative Stress Through the Autophagic and Survival Pathways

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Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes

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Ribozyme knockdown functionally links a 1,25(OH) 2 D 3 membrane binding protein (1,25D 3 -MARRS) and phosphate uptake in intestinal cells

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The Vitamin D Receptor: New Paradigms for the Regulation of Gene Expression by 1,25-Dihydroxyvitamin D3

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Molecular basis of the potential of vitamin D to prevent cancer

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Regulation of the vitamin D receptor gene by environment, genetics and epigenetics

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On the role of skin in the regulation of local and systemic steroidogenic activities

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Intestinal and Hepatic CYP3A4 Catalyze Hydroxylation of 1α,25-Dihydroxyvitamin D3: Implications for Drug-Induced Osteomalacia

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Vitamin D regulated keratinocyte differentiation

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The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions

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A pathway for the metabolism of vitamin D ₃ : Unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1)

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Vitamin D: an ancient hormone

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Vitamin D-3 Receptor as a Target for Breast Cancer Prevention

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An Undesired Effect of Chemotherapy

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Vitamin D status in patients with chronic plaque psoriasis

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1,25-Dihydroxyvitamin D3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage.

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The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism

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Protective role of 1α, 25‐dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells

Bao, B., Ting, H., Hsu, J., & Lee, Y. (2008) · International Journal of Cancer · doi:10.1002/ijc.23460 · Cited by 150 · see citing works

Effects of supplemental vitamin D and calcium on oxidative DNA damage marker in normal colorectal mucosa: A randomized clinical trial

Fedirko, V., Bostick, R. M., Long, Q., Flanders, W. D., McCullough, M. L., Sidelnikov, E., Daniel, C. R., Rutherford, R. E., & Shaukat, A. (2010) · Cancer Epidemiology, Biomarkers &amp; Prevention · doi:10.1158/1055-9965.epi-09-0448 · Cited by 150 · see citing works

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity

Slominski, A. T., Janjetovic, Z., Fuller, B. E., Zmijewski, M. A., Tuckey, R. C., Nguyen, M. N., Sweatman, T., Li, W., Zjawiony, J., Miller, D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009907 · Cited by 149 · see citing works

Calcium and 1,25(OH)2D: interacting drivers of epidermal differentiation

Bikle, D. D., Oda, Y., & Xie, Z. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.03.020 · Cited by 131 · see citing works

Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp‐9) and effector caspases (casp‐3/casp‐7) and PARP in UVR‐exposed HaCaT keratinocytes

Fischer, T. W., Zmijewski, M. A., Wortsman, J., & Slominski, A. T. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00542.x · Cited by 128 · see citing works

1,25‐dihydroxyvitamin D3 inhibits ultraviolet B‐induced apoptosis, Jun kinase activation, and interleukin‐6 production in primary human keratinocytes

Haes, P. D., Garmyn, M., Degreef, H. J., Vantieghem, K., Bouillon, R., & Segaert, S. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10540 · Cited by 128 · see citing works

Skin cancer prevention: A possible role of 1,25dihydroxyvitamin D3 and its analogs

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Mechanistic Effects of Calcitriol in Cancer Biology

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1 ,25-Dihydroxyvitamin D3 is a preventive factor in the metastasis of lung cancer

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Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: A systematic review and meta-analysis

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1α,25 Dihydroxyvitamin D3: Therapeutic and Preventive Effects against Oxidative Stress, Hepatic, Pancreatic and Renal Injury in Alloxan-Induced Diabetes in Rats

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Potentiation of cisplatin antitumor activity using a vitamin D analogue in a murine squamous cell carcinoma model system.

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Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc

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20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation

Zbytek, B., Janjetovic, Z., Tuckey, R. C., Zmijewski, M. A., Sweatman, T. W., Jones, E., Nguyen, M. N., & Slominski, A. T. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.62 · Cited by 118 · see citing works

20-Hydroxyvitamin D₂ is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells

Slominski, A. T., Kim, T.-K., Janjetovic, Z., Tuckey, R. C., Bieniek, R., Yue, J., Li, W., Chen, J., Nguyen, M. N., Tang, E. K. Y., et al. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00203.2010 · Cited by 113 · see citing works

Relation between prediagnostic serum 25-hydroxyvitamin D level and incidence of breast, colorectal, and other cancers

Grant, W. B. (2010) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2010.04.008 · Cited by 112 · see citing works

1,25-Dihydroxyvitamin D3 and analogues protect primary human keratinocytes against UVB-induced DNA damage

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1Alpha,25dihydroxyvitamin D3 and platinum drugs act synergistically to inhibit the growth of prostate cancer cell lines.

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1,25-Dihydroxyvitamin D and three low-calcemic analogs decrease UV-induced DNA damage via the rapid response pathway

Wong, G., Gupta, R., Dixon, K. M., Deo, S. S., Choong, S. M., Halliday, G. M., Bishop, J. E., Ishizuka, S., Norman, A. W., Posner, G. H., et al. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.03.072 · Cited by 102 · see citing works

Vitamin D receptor, a tumor suppressor in skin

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Vitamin D in combination cancer treatment

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The Vitamin D Receptor as Tumor Suppressor in Skin

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Sequential metabolism of 7-dehydrocholesterol to steroidal 5, 7-dienes in adrenal glands and its biological implication in the skin

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20<i>S</i>-Hydroxyvitamin D₃, Noncalcemic Product of CYP11A1 Action on Vitamin D₃, Exhibits Potent Antifibrogenic Activity in Vivo

Slominski, A., Janjetovic, Z., Tuckey, R. C., Nguyen, M. N., Bhattacharya, K. G., Wang, J., Li, W., Jiao, Y., Gu, W., Brown, M., et al. (2013) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2012-3074 · Cited by 89 · see citing works

Production of 22-hydroxy metabolites of vitamin D3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cells

Tuckey, R. C., Li, W., Shehabi, H. Z., Janjetovic, Z., Nguyen, M. N., Kim, T.-K., Chen, J., Howell, D. E., Benson, H. A. E., Sweatman, T., et al. (2011) · Drug Metabolism and Disposition · doi:10.1124/dmd.111.040071 · Cited by 88 · see citing works

Cisplatin potentiates 1,25-dihydroxyvitamin D3-induced apoptosis in association with increased mitogen-activated protein kinase kinase kinase 1 (MEKK-1) expression.

Hershberger, P. A., McGuire, T. F., Yu, W., Zuhowski, E. G., Schellens, J. H. M., Egorin, M. J., Trump, D. L., & Johnson, C. S. (2002) · PubMed · Cited by 85 · see citing works

25-hydroxyvitamin D and breast cancer, colorectal cancer, and colorectal adenomas: case-control versus nested case-control studies.

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1,25D3 Enhances antitumor activity of gemcitabine and cisplatin in human bladder cancer models

Ma, Y., Yu, W., Trump, D. L., & Johnson, C. S. (2010) · Cancer · doi:10.1002/cncr.25059 · Cited by 84 · see citing works

Novel vitamin D hydroxyderivatives inhibit melanoma growth and show differential effects on normal melanocytes.

Slominski, A. T., Janjetović, Z., Kim, T., Wright, A. C., Grese, L., Riney, S. J., Nguyen, M. N., & Tuckey, R. C. (2012) · PubMed · Cited by 84 · see citing works

Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes

Slominski, A. T., Kim, T.-K., Chen, J., Nguyen, M. N., Li, W., Yates, C. R., Sweatman, T., Janjetovic, Z., & Tuckey, R. C. (2012) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/j.biocel.2012.07.027 · Cited by 81 · see citing works

The Role of Vitamin D in Prostate Cancer

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Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation

Slominski, A. T., Janjetovic, Z., Kim, T.-K., Wasilewski, P., Rosas, S., Hanna, S., Sayre, R. M., Dowdy, J. C., Li, W., & Tuckey, R. C. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.01.014 · Cited by 77 · see citing works

Cisplatin-resistant prostate cancer model: Differences in antioxidant system, apoptosis and cell cycle

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Novel vitamin D photoproducts and their precursors in the skin

Slominski, A., Kim, T.-K., Zmijewski, M. A., Janjetovic, Z., Li, W., Chen, J., Kusniatsova, E. I., Semak, I., Postlethwaite, A., Miller, D. D., et al. (2013) · Dermato-Endocrinology · doi:10.4161/derm.23938 · Cited by 76 · see citing works

Iron, oxidative stress and the example of solar ultraviolet a radiation.

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20-hydroxyvitamin D₃ inhibits proliferation of cancer cells with high efficacy while being non-toxic.

Wang, J., Slominski, A. T., Tuckey, R. C., Janjetović, Z., Kulkarni, A. L., Chen, J., Postlethwaite, A. E., Miller, D. D., & Li, W. (2012) · UWA Profiles and Research Repository (UWA) · Cited by 74 · see citing works

Molecular Actions of 1,25-Dihydroxyvitamin D3 on Genes Involved in Calcium Homeostasis

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1α,25 Dihydroxyvitamin D3 enhances cellular defences against UV-induced oxidative and other forms of DNA damage in skin

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Ultraviolet Damage, DNA Repair and Vitamin D in Nonmelanoma Skin Cancer and in Malignant Melanoma

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Vitamin D: the light side of sunshine

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Vitamin D is a prooxidant in breast cancer cells.

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Correlation between secosteroid-induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength

Kim, T.-K., Wang, J., Janjetovic, Z., Chen, J., Tuckey, R. C., Nguyen, M. N., Tang, E. K. Y., Miller, D., Li, W., & Slominski, A. T. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.04.001 · Cited by 67 · see citing works

CYP11A1 in skin: an alternative route to photoprotection by vitamin D compounds

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Photo-conversion of two epimers (20R and 20S) of pregna-5,7-diene-3β, 17α, 20-triol and their bioactivity in melanoma cells

Zmijewski, M. A., Li, W., Zjawiony, J. K., Sweatman, T. W., Chen, J., Miller, D. D., & Slominski, A. T. (2009) · Steroids · doi:10.1016/j.steroids.2008.10.017 · Cited by 62 · see citing works

Role of the 1,25D3-MARRS receptor in the 1,25(OH)2D3-stimulated uptake of calcium and phosphate in intestinal cells

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Hydrogen protects auditory hair cells from cisplatin-induced free radicals

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Low doses of ethanolic extract of Boldo (Peumus boldus) can ameliorate toxicity generated by cisplatin in normal liver cells of mice in vivo and in WRL-68 cells in vitro, but not in cancer cells in vivo or in vitro

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1α,25‐dihydroxyvitamin D3 attenuates cyanide‐induced neurotoxicity by inhibiting uncoupling protein‐2 up‐regulation

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Molecular damage caused by generation of reactive oxygen species in the redox cycle of doxorubicin–transferrin conjugate in human leukemia cell lines

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Vitamin D receptor(s): In the nucleus but also at membranes?

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Vitamin D Receptor Is Necessary for Mitochondrial Function and Cell Health

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Protective Effects of Novel Derivatives of Vitamin D3 and Lumisterol Against UVB-Induced Damage in Human Keratinocytes Involve Activation of Nrf2 and P53 Defense Mechanisms

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Endogenously produced nonclassical vitamin D hydroxy-metabolites act as “biased” agonists on VDR and inverse agonists on RORα and RORγ

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Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management

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Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D

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Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage

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Differential and Overlapping Effects of 20,23(OH)2D3 and 1,25(OH)2D3 on Gene Expression in Human Epidermal Keratinocytes: Identification of AhR as an Alternative Receptor for 20,23(OH)2D3

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Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols

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Vitamin D Signaling in Psoriasis: Pathogenesis and Therapy

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The Role of Classical and Novel Forms of Vitamin D in the Pathogenesis and Progression of Nonmelanoma Skin Cancers

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Defect and Additional Active Sites on the Basal Plane of Manganese-Doped Molybdenum Diselenide for Effective Enzyme Immobilization: In Vitro and in Vivo Real-Time Analyses of Hydrogen Peroxide Sensing

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Myrtus Polyphenols, from Antioxidants to Anti-Inflammatory Molecules: Exploring a Network Involving Cytochromes P450 and Vitamin D

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Keratinocyte Growth Factor 2 Ameliorates UVB-Induced Skin Damage via Activating the AhR/Nrf2 Signaling Pathway

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Vitamin D and its low calcemic analogs modulate the anticancer properties of cisplatin and dacarbazine in the human melanoma A375 cell line

Piotrowska, A., Wierzbicka, J., Rybarczyk, A., Tuckey, R. C., Slominski, A. T., & Zmijewski, M. A. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4725 · Cited by 36 · see citing works

EXPRESSION OF CONCERN: Mitochondrial function is controlled by melatonin and its metabolites in vitro in human melanoma cells

Bilska, B., Schedel, F., Piotrowska, A., Stefan, J., Zmijewski, M. A., Pyza, E., Reiter, R. J., Steinbrink, K., Slominski, A. T., Tulić, M. K., et al. (2021) · Journal of Pineal Research · doi:10.1111/jpi.12728 · Cited by 34 · see citing works

Mitigative Effects of Topical Norfloxacin on an Imiquimod-Induced Murine Model of Psoriasis

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Metal ion homeostasis with emphasis on zinc and copper: Potential crucial link to explain the non-classical antioxidative properties of vitamin D and melatonin

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Eldecalcitol induces apoptosis and autophagy in human osteosarcoma MG-63 cells by accumulating ROS to suppress the PI3K/Akt/mTOR signaling pathway

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1α,25(OH)2D3 Radiosensitizes Cancer Cells by Activating the NADPH/ROS Pathway

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Mitochondrial potassium channels: A novel calcitriol target

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Recent Advancements Towards the Use of Vitamin D Isoforms and the Development of Their Synthetic Analogues as New Therapeutics

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Selective ability of rat 7-Dehydrocholesterol reductase (DHCR7) to act on some 7-Dehydrocholesterol metabolites but not on lumisterol metabolites

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Vitamin D Modulates the Response of Patient-Derived Metastatic Melanoma Cells to Anticancer Drugs

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Combined treatment of menadione and calcitriol increases the antiproliferative effect by promoting oxidative/nitrosative stress, mitochondrial dysfunction, and autophagy in breast cancer MCF-7 cells

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Vitamin D Enhances Anticancer Properties of Cediranib, a VEGFR Inhibitor, by Modulation of VEGFR2 Expression in Melanoma Cells

Piotrowska, A., Beserra, F. P., Wierzbicka, J., Nowak, J. I., & Zmijewski, M. A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.763895 · Cited by 12 · see citing works

PDIA3 modulates genomic response to 1,25-dihydroxyvitamin D3 in squamous cell carcinoma of the skin

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Different impact of vitamin D on mitochondrial activity and morphology in normal and malignant keratinocytes, the role of genomic pathway

Olszewska, A., Nowak, J. I., Król, O., Flis, D. J., & Zmijewski, M. A. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.11.033 · Cited by 10 · see citing works

Physiological and transcriptomic analysis revealed the alleviating effect of 1,25(OH)2D3 on environmental iron overloading induced ferroptosis in zebrafish

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Antiproliferative activity of side-chain truncated vitamin D analogs (PRI-1203 and PRI-1204) against human malignant melanoma cell lines

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Nanoparticles and skin cancer

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Acute hepatologic and nephrologic effects of calcitriol in Syrian golden hamster (Mesocricetus auratus)

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Blackcurrant Anthocyanins Improve Blood Lipids and Biomarkers of Inflammation and Oxidative Stress in Healthy Women in Menopause Transition without Changing Body Composition

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Vitamin D ameliorates liver pathology in mice caused by exposure to endocrine disruptor bisphenol A

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Vitamin D3–assisted chemo-photodynamic therapy of rhabdomyosarcoma cancer cells for effective treatment

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Therapeutic potential of vitamin D against bisphenol A-induced spleen injury in Swiss albino mice

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Fibroblast Growth Factor Receptor Inhibitors Decrease Proliferation of Melanoma Cell Lines and Their Activity Is Modulated by Vitamin D

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Cytotoxicity and DNA Damage Ability of Isomeric meso -Tetra(cisplatin)porphyrins in Keratinocytes and Melanoma Cells Treated with Photodynamic Therapy

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Neuroprotective Triterpenoids from Mastic Gum ( Pistacia lentiscus L.)

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Supraphysiological 25‐Hydroxyvitamin D 3 and Calcipotriol Induce Reactive Oxygen Species, Mitochondrial Dysfunction and Apoptosis in HeLa Cervical Cancer Cells

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Vitamin D protects keratinocytes from deleterious effects of ionizing radiation

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1,25-Dihydroxvitamin D3 attenuates the damage of human immortalised keratinocytes caused by Ultraviolet-B

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Supraphysiological 25‐Hydroxyvitamin D 3 and Calcipotriol Induce Reactive Oxygen Species, Mitochondrial Dysfunction and Apoptosis in HeLa Cervical Cancer Cells

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