The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet: Nutrition Reviews©, Vol. 68, No. 6
Abstract
The diverse nature of intestinal alkaline phosphatase (IAP) functions has remained elusive, and it is only recently that four additional major functions of IAP have been revealed. The present review analyzes the earlier literature on the dietary factors modulating IAP activity in light of these new findings. IAP regulates lipid absorption across the apical membrane of enterocytes, participates in the regulation of bicarbonate secretion and of duodenal surface pH, limits bacterial transepithelial passage, and finally controls bacterial endotoxin-induced inflammation by dephosphorylation, thus detoxifying intestinal lipopolysaccharide. Many dietary components, including fat, protein, and carbohydrate, modulate IAP expression or activity and may be combined to sustain a high level of IAP activity. In conclusion, IAP has a pivotal role in intestinal homeostasis and its activity could be increased through the diet. This is especially true in pathological situations (e.g., inflammatory bowel diseases) in which the involvement of commensal bacteria is suspected and when intestinal AP is too low to detoxify a sufficient amount of bacterial lipopolysaccharide.
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Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition
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The biological stress of early weaned piglets
Campbell, J. M., Crenshaw, J. D., & Polo, J. (2013) · Journal of Animal Science and Biotechnology · doi:10.1186/2049-1891-4-19 · Cited by 1,014
Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia
Moreira, A. P. B., Texeira, T. F. S., Ferreira, A. B., do Carmo Gouveia Peluzio, M., & de Cássia Gonçalves Alfenas, R. (2012) · British Journal of Nutrition · doi:10.1017/s0007114512001213 · Cited by 655
Diabetes, obesity and gut microbiota
Everard, A., & Cani, P. D. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.007 · Cited by 543
Intestinal alkaline phosphatase: novel functions and protective effects
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Self-citation
Metadata
- Authors
- Lallès, J.-P.
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-06
- Volume
- 68
- Issue
- 6
- Pages
- 323-332
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2145043315
- Cited by
- 355
- References
- 66
- FWCI
- 13.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lallès, J.-P. (2010). Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet: Nutrition Reviews©, Vol. 68, No. 6. Nutrition Reviews. https://doi.org/10.1111/j.1753-4887.2010.00292.x
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