The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Novel MITF targets identified using a two‐step DNA microarray strategy
Open accessAbstract
Summary: Malignant melanoma is a chemotherapy‐resistant cancer with high mortality. Recent advances in our understanding of the disease at the molecular level have indicated that it shares many characteristics with developmental precursors to melanocytes, the mature pigment‐producing cells of the skin and hair follicles. The development of melanocytes absolutely depends on the action of the microphthalmia‐associated transcription factor (MITF). MITF has been shown to regulate a broad variety of genes, whose functions range from pigment production to cell‐cycle regulation, migration and survival. However, the existing list of targets is not sufficient to explain the role of MITF in melanocyte development and melanoma progression. DNA microarray analysis of gene expression offers a straightforward approach to identify new target genes, but standard analytical procedures are susceptible to the generation of false positives and require additional experimental steps for validation. Here, we introduce a new strategy where two DNA microarray‐based approaches for identifying transcription factor targets are combined in a cross‐validation protocol designed to help control false‐positive generation. We use this two‐step approach to successfully re‐identify thirteen previously recorded targets of MITF‐mediated upregulation, as well as 71 novel targets. Many of these new targets have known relevance to pigmentation and melanoma biology, and further emphasize the critical role of MITF in these processes.
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Cites
Controlling the false discovery rate in behavior genetics research
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Melanocytes and the Microphthalmia Transcription Factor Network
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In vivo Switching of Human Melanoma Cells between Proliferative and Invasive States
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Mitf regulation of Dia1 controls melanoma proliferation and invasiveness
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Cited by
Tsoi, J., Robert, L., Paraiso, K., Galvan, C., Sheu, K. M., Lay, J., Wong, D. J. L., Atefi, M., Shirazi, R., Wang, X., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.017 · Cited by 938
Martina, J. A., Diab, H. I., Lishu, L., Jeong-A, L., Patange, S., Raben, N., & Puertollano, R. (2014) · Science Signaling · doi:10.1126/scisignal.2004754 · Cited by 677
An integrated approach to uncover drivers of cancer
Akavia, U. D., Litvin, O., Kim, J., Sanchez-Garcia, F., Kotliar, D., Causton, H. C., Pochanard, P., Mozes, E., Garraway, L. A., & Pe'er, D. (2010) · Cell · doi:10.1016/j.cell.2010.11.013 · Cited by 484
Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state
Verfaillie, A., Imrichova, H., Atak, Z. K., Dewaele, M., Rambow, F., Hulselmans, G., Christiaens, V., Svetlichnyy, D., Luciani, F., Van den Mooter, L., et al. (2015) · Nature Communications · doi:10.1038/ncomms7683 · Cited by 489
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
Yokoyama, S., Woods, S. L., Boyle, G. M., Aoude, L. G., MacGregor, S., Zismann, V., Gartside, M., Cust, A. E., Haq, R., Harland, M., et al. (2011) · Nature · doi:10.1038/nature10630 · Cited by 484
Metadata
- Authors
- Hoek, K. S., Schlegel, N. C., Eichhoff, O. M., Widmer, D. S., Praetorius, C., Einarsson, S. O., Valgeirsdottir, S., Bergsteinsdottir, K., Schepsky, A., Dummer, R., & Steingrimsson, E.
- Venue
- Pigment Cell & Melanoma Research
- Publisher
- Wiley
- Published
- 2008-11-11
- Volume
- 21
- Issue
- 6
- Pages
- 665-676
- ISSN
- 1755-1471 (ISSN-L)
- 1755-148X
- OpenAlex
- W2092129054
- Cited by
- 262
- References
- 74
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hoek, K. S., Schlegel, N. C., Eichhoff, O. M., Widmer, D. S., Praetorius, C., Einarsson, S. O., Valgeirsdottir, S., Bergsteinsdottir, K., Schepsky, A., Dummer, R., & Steingrimsson, E. (2008). Novel MITF targets identified using a two‐step DNA microarray strategy. Pigment Cell & Melanoma Research. https://doi.org/10.1111/j.1755-148x.2008.00505.x
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