The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10
Open accessAbstract
Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural stem cells into wild-type hosts showing the permanent, cell-autonomous nature of the defect. Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms.
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Cites
The transcription factor Sox10 is a key regulator of peripheral glial development
Britsch, S., Goerich, D. E., Riethmacher, D., Peirano, R. I., Rossner, M., Nave, K.-A., Birchmeier, C., & Wegner, M. (2001) · Genes & Development · doi:10.1101/gad.186601 · Cited by 914
Self-citationFrom head to toes: the multiple facets of Sox proteins
Wegner, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.6.1409 · Cited by 890
Self-citationLu, Q. R., Yuk, D.-I., Alberta, J. A., Zhu, Z., Pawlitzky, I., Chan, J., McMahon, A. P., Stiles, C. D., & Rowitch, D. H. (2000) · Neuron · doi:10.1016/s0896-6273(00)80897-1 · Cited by 852
SOX10 mutations in patients with Waardenburg-Hirschsprung disease
Pingault, V., Bondurand, N., Kuhlbrodt, K., Goerich, D. E., Préhu, M.-O., Puliti, A., Herbarth, B., Hermans-Borgmeyer, I., Legius, E., Matthijs, G., et al. (1998) · Nature Genetics · doi:10.1038/ng0298-171 · Cited by 825
Self-citationZhou, Q., Wang, S., & Anderson, D. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)80898-3 · Cited by 789
Sox10, a Novel Transcriptional Modulator in Glial Cells
Kuhlbrodt, K., Herbarth, B., Sock, E., Hermans-Borgmeyer, I., & Wegner, M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00237.1998 · Cited by 781
Self-citationSOX10 mutation disrupts neural crest development in Dom Hirschsprung mouse model
Southard-Smith, E. M., Kos, L., & Pavan, W. J. (1998) · Nature Genetics · doi:10.1038/ng0198-60 · Cited by 738
Severe neuropathies in mice with targeted mutations in the ErbB3 receptor
Riethmacher, D., Sonnenberg-Riethmacher, E., Brinkmann, V., Yamaai, T., Lewin, G. R., & Birchmeier, C. (1997) · Nature · doi:10.1038/39593 · Cited by 729
Self-citationPairing SOX off: with partners in the regulation of embryonic development
Kamachi, Y., Uchikawa, M., & Kondoh, H. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(99)01955-1 · Cited by 639
Canoll, P. D., Musacchio, J. M., Hardy, R., Reynolds, R., Marchionni, M. A., & Salzer, J. L. (1996) · Neuron · doi:10.1016/s0896-6273(00)80155-5 · Cited by 374
Cited by
Kessaris, N., Fogarty, M., Iannarelli, P., Grist, M., Wegner, M., & Richardson, W. D. (2006) · Nature Neuroscience · doi:10.1038/nn1620 · Cited by 1,195
Myelination of the Nervous System: Mechanisms and Functions
Nave, K.-A., & Werner, H. B. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013101 · Cited by 983
Oligodendrocyte dysfunction in schizophrenia and bipolar disorder
Tkachev, D., Mimmack, M. L., Ryan, M. M., Wayland, M., Freeman, T., Jones, P. B., Starkey, M., Webster, M. J., Yolken, R. H., & Bahn, S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14289-4 · Cited by 933
A gene regulatory network orchestrates neural crest formation
Sauka-Spengler, T., & Bronner-Fraser, M. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2428 · Cited by 728
The Sox9 transcription factor determines glial fate choice in the developing spinal cord
Stolt, C. C., Lommes, P., Sock, E., Chaboissier, M.-C., Schedl, A., & Wegner, M. (2003) · Genes & Development · doi:10.1101/gad.259003 · Cited by 636
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Metadata
- Authors
- Stolt, C. C., Rehberg, S., Ader, M., Lommes, P., Riethmacher, D., Schachner, M., Bartsch, U., & Wegner, M.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-01-15
- Volume
- 16
- Issue
- 2
- Pages
- 165-170
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2109734495
- Cited by
- 684
- References
- 26
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Stolt, C. C., Rehberg, S., Ader, M., Lommes, P., Riethmacher, D., Schachner, M., Bartsch, U., & Wegner, M. (2002). Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. Genes & Development. https://doi.org/10.1101/gad.215802
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