An integrated approach to uncover drivers of cancer

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Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

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The transcriptional network for mesenchymal transformation of brain tumours

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MITF: master regulator of melanocyte development and melanoma oncogene

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Control of Macroautophagy by Calcium, Calmodulin-Dependent Kinase Kinase-β, and Bcl-2

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Promiscuous Mutations Activate the Noncanonical NF-κB Pathway in Multiple Myeloma

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Frequent Engagement of the Classical and Alternative NF-κB Pathways by Diverse Genetic Abnormalities in Multiple Myeloma

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4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

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Melanocytes and theMicrophthalmiaTranscription Factor Network

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Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability

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<i>In vivo</i> Switching of Human Melanoma Cells between Proliferative and Invasive States

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A module map showing conditional activity of expression modules in cancer

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FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport

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V600E BRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway

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Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

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Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature

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PTEN-deficient cancers depend on PIK3CB

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Malignant melanoma: genetics and therapeutics in the genomic eraPreprint

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Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) and Multi-Targeted Kinase Inhibitor, in Patients With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3

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KLF6 , a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer

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The sortilin cytoplasmic tail conveys Golgi–endosome transport and binds the VHS domain of the GGA2 sorting protein

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An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer

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Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets

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Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions

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Activation of the novel stress‐activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

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Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF

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Patterns of Gene Expression and Copy-Number Alterations in von-Hippel Lindau Disease-Associated and Sporadic Clear Cell Carcinoma of the Kidney

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The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes

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Acute-Phase Serum Amyloid A: An Inflammatory Adipokine and Potential Link between Obesity and Its Metabolic Complications

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GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer

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A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse

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Automated Network Analysis Identifies Core Pathways in Glioblastoma

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Novel Role of Antioxidant-1 (Atox1) as a Copper-dependent Transcription Factor Involved in Cell Proliferation

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Probabilistic models of indexing and searching

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Modeling Genomic Diversity and Tumor Dependency in Malignant Melanoma

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Identification of Common Transcriptional Regulatory Elements in Interleukin-17 Target Genes

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Oncogenic BRAF Regulates Melanoma Proliferation through the Lineage Specific Factor MITF

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Novel MITF targets identified using a two‐step DNA microarray strategy

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GREB1 is a critical regulator of hormone dependent breast cancer growth

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The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis

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Acquired copy number alterations in adult acute myeloid leukemia genomes

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Genome-wide identification of post-translational modulators of transcription factor activity in human B cells

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Genetic regulators of large-scale transcriptional signatures in cancer

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Lipocalin 2 Is Required for Pulmonary Host Defense against Klebsiella Infection

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Identification of the SPG15 Gene, Encoding Spastizin, as a Frequent Cause of Complicated Autosomal-Recessive Spastic Paraplegia, Including Kjellin Syndrome

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Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians

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Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase

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The Tumor Suppressor Cylindromatosis (CYLD) Acts as a Negative Regulator for Toll-like Receptor 2 Signaling via Negative Cross-talk with TRAF6 and TRAF7

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Hermansky-Pudlak syndrome is caused by mutations in HPS4, the human homolog of the mouse light-ear gene

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Etk/Bmx Transactivates Vascular Endothelial Growth Factor 2 and Recruits Phosphatidylinositol 3-Kinase to Mediate the Tumor Necrosis Factor-induced Angiogenic Pathway

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Functional Identification of Tumor-Suppressor Genes through an In Vivo RNA Interference Screen in a Mouse Lymphoma Model

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Screening for target Rabs of TBC (Tre‐2/Bub2/Cdc16) domain‐containing proteins based on their Rab‐binding activity

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Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells

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NF‐κB activation in melanoma

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Structural basis for recognition of acidic-cluster dileucine sequence by GGA1

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Identifying regulatory mechanisms using individual variation reveals key role for chromatin modification

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Learning Module NetworksPreprint

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The NR4A Orphan Nuclear Receptor NOR1 Is Induced by Platelet-derived Growth Factor and Mediates Vascular Smooth Muscle Cell Proliferation

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Mig-6 controls EGFR trafficking and suppresses gliomagenesis

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The P2Y2 Nucleotide Receptor Mediates UTP-induced Vascular Cell Adhesion Molecule-1 Expression in Coronary Artery Endothelial Cells

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A Comparative and Integrative Approach Identifies ATPase Family, AAA Domain Containing 2 as a Likely Driver of Cell Proliferation in Lung Adenocarcinoma

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Chromosomal Instability Selects Gene Copy-Number Variants Encoding Core Regulators of Proliferation in ER+ Breast Cancer

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Abstract B70: Conexic: A Bayesian framework to detect drivers and their function uncovers an endosomal signature in melanoma

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Cancer driver gene discovery through an integrative genomics approach in a non-parametric Bayesian framework

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