The DOI matches its Crossref record; 146 of the 146 references it cites were found in a registry or an index.
The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin
Open accessAbstract
Summary: Converging lines of evidence from varied scientific disciplines suggest that cutaneous melanomas comprise biologically distinct subtypes that arise through multiple causal pathways. Understanding the respective relationships of each subtype with etiologic factors such as UV radiation and constitutional factors is the first necessary step toward developing refined prevention strategies for the specific forms of melanoma. Furthermore, classifying this disease precisely into biologically distinct subtypes is the key to developing mechanism‐based treatments, as highlighted by recent discoveries. In this review, we outline the historical developments that underpin our understanding of melanoma heterogeneity, and we do this from the perspectives of clinical presentation, histopathology, epidemiology, molecular genetics, and developmental biology. We integrate the evidence from these separate trajectories to catalog the emerging major categories of melanomas and conclude with important unanswered questions relating to the development of melanoma and its cells of origin.
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Cites
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Self-citationMassive genomic rearrangement acquired in a single catastrophic event during cancer development
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Cited by
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
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Self-citationUltraviolet Radiation and Melanoma
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Metadata
- Authors
- Whiteman, D. C., Pavan, W. J., & Bastian, B. C.
- Venue
- Pigment Cell & Melanoma Research
- Publisher
- Wiley
- Published
- 2011-08-16
- Volume
- 24
- Issue
- 5
- Pages
- 879-897
- ISSN
- 1755-1471 (ISSN-L)
- 1755-148X
- OpenAlex
- W2090420216
- Cited by
- 273
- References
- 146
- FWCI
- 11.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin. https://app.cochat.ai/papers/10.1111/j.1755-148x.2011.00880.x
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- Whiteman, D. C., Pavan, W. J., & Bastian, B. C. (2011). The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin. Pigment Cell & Melanoma Research. https://doi.org/10.1111/j.1755-148x.2011.00880.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
