Ultraviolet Radiation and Melanoma

Kanavy, Holly E.; Gerstenblith, Meg R.

doi:10.1016/j.sder.2011.08.003

Cited by 170Skin Protection and AgingCutaneous Melanoma Detection and Managementmelanin and skin pigmentation

Ultraviolet Radiation and Melanoma

Kanavy, Holly E., Gerstenblith, Meg R.·2011·Seminars in Cutaneous Medicine and Surgery

DOI 10.1016/j.sder.2011.08.003

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Abstract

Melanoma is a particularly aggressive type of skin cancer, and its incidence has been increasing steadily since the 1970s. This article will review the extensive epidemiologic data demonstrating that ultraviolet radiation (UVR) exposure, from the sun or artificial tanning beds, is the most important environmental risk factor for melanoma; the multiple detrimental effects of UVR on human skin, including DNA damage through the formation of dimeric photoproducts, gene mutations, oxidative stress, inflammation, and immunosuppression, all of which contribute to melanomagenesis; and the evidence that protection from UVR exposure, whether by melanin or by sunscreen, reduces the risk of developing melanoma.

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Basal cell carcinoma and malignant melanoma incidence is mostly related to intermittent solar exposure during childhood and adolescence.
“In contrast, basal cell carcinoma and malignant melanoma incidence appears to be mostly related to intermittent exposure to solar light during childhood and adolescence (1), although the situation for melanoma appears to be more complex (2).”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup> (2012) · cites this paper as [2]

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Authors: Kanavy, H. E., & Gerstenblith, M. R.
Affiliations: University Hospitals Cleveland Medical Center (US)
ORCID: Gerstenblith, Meg R.
Venue: Seminars in Cutaneous Medicine and Surgery
Publisher: Frontline Medical Communications, Inc.
Published: 2011-12
Volume: 30
Issue: 4
Pages: 222-228
ISSN: 1085-5629 (ISSN-L)
DOI: 10.1016/j.sder.2011.08.003
OpenAlex: W2119277951
Cited by: 170
References: 85
Citations by year: 2026: 1 · 2025: 8 · 2024: 6 · 2023: 7 · 2022: 12 · 2021: 13 · 2020: 10 · 2019: 16 · 2018: 14 · 2017: 9 · 2016: 16 · 2015: 12 · 2014: 15 · 2013: 18 · 2012: 8
FWCI: 2.21
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Cutaneous Medicine and Surgery (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords: melanoma, ultraviolet radiation, tanning beds, sun exposure, melanomagenesis, DNA damage, photoproducts, genetic mutations, oxidative stress, skin inflammation, immunosuppression, melanin, sunscreen, melanoma prevention, environmental risk factors
MeSH terms: Cell Transformation, Neoplastic, DNA Damage, Humans, Melanoma, Sunlight, Ultraviolet Rays, Incidence

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Ultraviolet Radiation and Melanoma

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