Cited by 229Dementia and Cognitive Impairment ResearchEpilepsy research and treatmentAlzheimer's disease research and treatments

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Seizures and Epilepsy in Alzheimer's Disease

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Friedman, Daniel, Honig, Lawrence S., Scarmeas, Nikolaos·2012·CNS Neuroscience & Therapeutics

DOI 10.1111/j.1755-5949.2011.00251.xPMC PMC3630499

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Abstract

SUMMARY: Many studies have shown that patients with Alzheimer's disease (AD) are at increased risk for developing seizures and epilepsy. However, reported prevalence and incidence of seizures and relationship of seizures to disease measures such as severity, outcome, and progression vary widely between studies. We performed a literature review of the available clinical and epidemiological data on the topic of seizures in patients with AD. We review seizure rates and types, risk factors for seizures, electroencephalogram (EEG) studies, and treatment responses. Finally, we consider limitations and methodological issues. There is considerable variability in the reported prevalence and incidence of seizures in patients with AD—with reported lifetime prevalence rates of 1.5–64%. More recent, prospective, and larger studies in general report lower rates. Some, but not all, studies have noted increased seizure risk with increasing dementia severity or with younger age of AD onset. Generalized convulsive seizures are the most commonly reported type, but often historical information is the only basis used to determine seizure type and the manifestation of seizures may be difficult to distinguish from other behaviors common in demented patients. EEG has infrequently been performed and reported. Data on treatment of seizures in AD are extremely limited. Similarly, the relationship between seizures and cognitive impairment in AD is unclear. We conclude that the literature on seizures and epilepsy in AD, including diagnosis, risk factors, and response to treatment suffers from methodological limitations and gaps.

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Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Incidence of Epilepsy and Unprovoked Seizures in Rochester, Minnesota: 1935–1984
Hauser, W. A., Annegers, J. F., & Kurland, L. T. (1993) · Epilepsia · doi:10.1111/j.1528-1157.1993.tb02586.x · Cited by 2,084
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of alzheimer’s disease.
Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Yoo, J., Ho, K. O., Yu, G.-Q., Kreitzer, A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.025 · Cited by 1,653
Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
Palop, J. J., & Mucke, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2583 · Cited by 1,651
How common are the "common" neurologic disorders?
Hirtz, D., Thurman, D. J., Gwinn-Hardy, K., Mohamed, M., Chaudhuri, A. R., & Zalutsky, R. (2007) · Neurology · doi:10.1212/01.wnl.0000252807.38124.a3 · Cited by 1,365
HOW COMMON ARE THE “COMMON” NEUROLOGIC DISORDERS?
Kaplin, A. I., & Williams, M. (2007) · Neurology · doi:10.1212/01.wnl.0000278071.91524.4d · Cited by 1,132
Limbic seizures produced by pilocarpine in rats: Behavioural, electroencephalographic and neuropathological study
Turski, W. A., Cavalheiro, É. A., Schwarz, M., Czuczwar, S. J., Kleinrok, Z., & Turski, L. (1983) · Behavioural Brain Research · doi:10.1016/0166-4328(83)90136-5 · Cited by 1,114
Brain Inflammation in Epilepsy: Experimental and Clinical Evidence
Vezzani, A., & Granata, T. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.00298.x · Cited by 1,049
Apolipoprotein E and Alzheimer disease.
Strittmatter, W. J., & Roses, A. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.4725 · Cited by 701

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Authors: Friedman, D., Honig, L. S., & Scarmeas, N.
Affiliations: NYU Langone Health (US)
Columbia University Irving Medical Center (US)
Corresponding author: Friedman, Daniel
ORCID: Friedman, Daniel
Honig, Lawrence S.
Scarmeas, Nikolaos
Venue: CNS Neuroscience & Therapeutics
Publisher: Wiley
Published: 2011-06-07
Volume: 18
Issue: 4
Pages: 285-294
ISSN: 1755-5930 (ISSN-L)
1755-5949
DOI: 10.1111/j.1755-5949.2011.00251.x
PMC: PMC3630499
OpenAlex: W1570043013
Cited by: 229
References: 72
Citations by year: 2026: 16 · 2025: 13 · 2024: 18 · 2023: 16 · 2022: 15 · 2021: 33 · 2020: 21 · 2019: 17 · 2018: 18 · 2017: 9 · 2016: 14 · 2015: 13 · 2014: 12 · 2013: 5 · 2012: 9
FWCI: 1.09
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: CNS Neuroscience & Therapeutics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (P50AG008702)
National Center for Research Resources (M01RR000645)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: Alzheimer's disease, seizures, epilepsy, seizure prevalence, seizure incidence, risk factors, generalized convulsions, EEG, anticonvulsant therapy, dementia severity, cognitive impairment, methodological limitations
MeSH terms: Alzheimer Disease, Animals, Cognition Disorders, Electroencephalography, Epilepsy, Humans, Prospective Studies, Retrospective Studies, Risk Factors, Seizures

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Seizures and Epilepsy in Alzheimer's Disease

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