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Cited by 172Dementia and Cognitive Impairment ResearchEpilepsy research and treatmentAlzheimer's disease research and treatments

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Association of epileptiform abnormalities and seizures in Alzheimer disease.

Open access
Lam, Alice D., Sarkis, Rani A., Pellerin, Kyle R., Jing, Jin, Dworetzky, Barbara A., Hoch, Daniel B., Jacobs, Claire S., Lee, Jong Woo, Weisholtz, Daniel S., Zepeda, Rodrigo, Westover, M. Brandon, Cole, Andrew J., Cash, Sydney S.·2020·Neurology
DOI 10.1212/wnl.0000000000010612PMC PMC7713786
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Abstract

Objective To examine the relationship between scalp EEG biomarkers of hyperexcitability in Alzheimer disease (AD) and to determine how these electric biomarkers relate to the clinical expression of seizures in AD. Methods In this cross-sectional study, we performed 24-hour ambulatory scalp EEGs on 43 cognitively normal elderly healthy controls (HC), 41 participants with early-stage AD with no history or risk factors for epilepsy (AD-NoEp), and 15 participants with early-stage AD with late-onset epilepsy related to AD (AD-Ep). Two epileptologists blinded to diagnosis visually reviewed all EEGs and annotated all potential epileptiform abnormalities. A panel of 9 epileptologists blinded to diagnosis was then surveyed to generate a consensus interpretation of epileptiform abnormalities in each EEG. Results Epileptiform abnormalities were seen in 53% of AD-Ep, 22% of AD-NoEp, and 4.7% of HC. Specific features of epileptiform discharges, including high frequency, robust morphology, right temporal location, and occurrence during wakefulness and REM, were associated with clinical seizures in AD. Multiple EEG biomarkers concordantly demonstrated a pattern of left temporal lobe hyperexcitability in early stages of AD, whereas clinical seizures in AD were often associated with bitemporal hyperexcitability. Frequent small sharp spikes were specifically associated with epileptiform EEGs and thus identified as a potential biomarker of hyperexcitability in AD. Conclusion Epileptiform abnorm…

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Metadata

Authors
Lam, A. D., Sarkis, R. A., Pellerin, K. R., Jing, J., Dworetzky, B. A., Hoch, D. B., Jacobs, C. S., Lee, J. W., Weisholtz, D. S., Zepeda, R., Westover, M. B., Cole, A. J., & Cash, S. S.
Affiliations
Brigham and Women's Hospital (US)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2020-10-20
Volume
95
Issue
16
Pages
e2259-e2270
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0000000000010612
PMC
PMC7713786
OpenAlex
W3046988908
Cited by
172
References
3
Citations by year
2026: 22 · 2025: 36 · 2024: 32 · 2023: 37 · 2022: 22 · 2021: 21 · 2020: 1
FWCI
14.78
Type
journal article
Language
en
Open access
Locations
  • Neurology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (P30AG062421)
  • National Institute of Neurological Disorders and Stroke (R01NS102574, R01NS062092, K23NS090900, K23NS101037, K24NS088568, R01NS102190, R01NS107291, R25NS065743)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, epileptiform abnormalities, seizures, hyperexcitability, EEG biomarkers, REM sleep, seizure risk
MeSH terms
Aged, Alzheimer Disease, Cross-Sectional Studies, Electroencephalography, Epilepsy, Female, Humans, Male, Risk Factors, Seizures, Biomarkers

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