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Acupuncture Stimulation on GB 34 Activates Neural Responses Associated with Parkinson's Disease
Open accessAbstract
Summary: Background: Parkinson's disease (PD) is a degenerative brain disorder that is caused by neural defects in the substantia nigra. Numerous studies have reported that acupuncture treatment on GB 34 (Yanglingquan) leads to significant improvements in patients with PD and in PD animal models. Studies using functional magnetic resonance imaging (fMRI) have shown that patients with PD, compared to healthy participants, have lower neural responses in extensive brain regions including the putamen, thalamus, and the supplementary motor area. Objective: This study investigated the reported association between acupuncture point GB 34 and PD. Methods: Using fMRI, neural responses of 12 patients with PD and 12 healthy participants were examined before and after acupuncture stimulation. Results: Acupuncture stimulation increased neural responses in regions including the substantia nigra, caudate, thalamus, and putamen, which are impaired caused by PD. Conclusions: Areas associated with PD were activated by the acupuncture stimulation on GB 34. This shows that acupuncture treatment on GB 34 may be effective in improving the symptoms of PD. Although more randomized controlled trials on the topic will be needed, this study shows that acupuncture may be helpful in the treatment of symptoms involving PD.
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Stimulation of ST34 has been associated with activation of neural responses, by activating precentral gyrus and prefrontal cortex associated with Parkinson's disease.
“Also, in the literature, the stimulation of this point has been associated with the activation of neural responses, by activating precentral gyrus and prefrontal cortex associated with PD [54], [55], [56].”
From Analysis of patellar reflex in Parkinson disease patients after an acupuncture treatment protocol – Case series study (2025) · cites this paper as [54]
The Acupuncture methods section says the study stimulated GB34, not ST34. The Discussion reports increased prefrontal-gyrus responses after acupuncture in patients with Parkinson’s disease, but identifies the precentral gyrus as an area with lower responses before stimulation, not one activated by it. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson’s disease
Yeo, S., Choe, I.-H., van den Noort, M., Bosch, P., Jahng, G.-H., Rosen, B., Kim, S.-H., & Lim, S. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-336 · Cited by 64
Self-citationPereira, C. R., Machado, J., Criado, B., Santos, R., Reis, A. M., Ramos, B., Santos, M. J., & Greten, H. J. (2025) · Clinical Parkinsonism & Related Disorders · doi:10.1016/j.prdoa.2025.100324 · Cited by 1
“To address the subjectivity in the assessment of reflexes and introduce a quantitative and objective approach, we conducted a study with the assistance of Biopac [54] with E-Rehabilitation technology [55].”
Metadata
- Authors
- Yeo, S., Lim, S., Choe, I., Choi, Y., Chung, K., Jahng, G., & Kim, S.
- Affiliations
- Kyung Hee University (KR)
- Corresponding author
- Lim, Sabina
- Venue
- CNS Neuroscience & Therapeutics
- Publisher
- Wiley
- Published
- 2012-09
- Volume
- 18
- Issue
- 9
- Pages
- 781-790
- ISSN
- 1755-5930 (ISSN-L)
- 1755-5949
- PMC
- PMC6493472
- OpenAlex
- W2133874540
- Cited by
- 60
- References
- 58
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 9 · 2015: 6 · 2014: 9 · 2013: 4
- FWCI
- 14.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- CNS Neuroscience & Therapeutics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation
- Ministry of Health and Welfare
- National Research Foundation of Korea
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Acupuncture Treatment Research Studies
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Studies
- Keywords
- Parkinson's disease, acupuncture, substantia nigra, neural responses, caudate nucleus, thalamus, putamen, brain activation
- MeSH terms
- Adult, Aged, Brain, Brain Mapping, Caudate Nucleus, Evoked Potentials, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Parkinson Disease, Putamen, Reference Values, Substantia Nigra, Thalamus, Acupuncture Points, Acupuncture Therapy, Case-Control Studies, Matched-Pair Analysis
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