Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson’s disease

Yeo, Sujung; Choe, Il-Hwan; van den Noort, Maurits; Bosch, Peggy; Jahng, Geon-Ho; Rosen, Bruce; Kim, Sung-Hoon; Lim, Sabina

doi:10.1186/1472-6882-14-336

Cited by 65Acupuncture Treatment Research StudiesTraditional Chinese Medicine StudiesTranscranial Magnetic Stimulation Studies

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Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson’s disease

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Yeo, Sujung, Choe, Il-Hwan, van den Noort, Maurits, Bosch, Peggy, Jahng, Geon-Ho, Rosen, Bruce, Kim, Sung-Hoon, Lim, Sabina·2014·BMC Complementary and Alternative Medicine

DOI 10.1186/1472-6882-14-336PMC PMC4175221

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Abstract

BACKGROUND: Acupuncture is increasingly used as an additional treatment for patients with Parkinson's disease (PD). METHODS: In this functional magnetic resonance imaging study, brain activation in response to acupuncture in a group of 12 patients with PD was compared with a group of 12 healthy participants. Acupuncture was conducted on a specific acupoint, the right GB 34 (Yanglingquan), which is a frequently used acupoint for motor function treatment in the oriental medical field. RESULTS: Acupuncture stimulation on this acupoint activates the prefrontal cortex, precentral gyrus, and putamen in patients with PD; areas that are known to be impaired in patients with PD. Compared with healthy participants, patients with PD showed significantly higher brain activity in the prefrontal cortex and precentral gyrus, especially visible in the left hemisphere. CONCLUSIONS: The neuroimaging results of our study suggest that in future acupuncture research; the prefrontal cortex as well as the precentral gyrus should be treated for symptoms of Parkinson's disease and that GB 34 seems to be a suitable acupoint. Moreover, acupuncture evoked different brain activations in patients with Parkinson's disease than in healthy participants in our study, stressing the importance of conducting acupuncture studies on both healthy participants as well as patients within the same study, in order to detect acupuncture efficacy. TRIAL REGISTRATION: KCT0001122 at cris.nih.go.kr (registration date: 20140530).

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Stimulation of ST34 has been associated with activation of neural responses, by activating precentral gyrus and prefrontal cortex associated with Parkinson's disease.
“Also, in the literature, the stimulation of this point has been associated with the activation of neural responses, by activating precentral gyrus and prefrontal cortex associated with PD [54], [55], [56].”
From Analysis of patellar reflex in Parkinson disease patients after an acupuncture treatment protocol – Case series study (2025) · cites this paper as [56]
The Discussion reports activation of the prefrontal cortex and precentral gyrus in patients with Parkinson’s disease, but the stimulated point was GB34, not ST34. The neural-response finding matches; its attribution to ST34 does not. (LLM, conf=0.90)
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Acupuncture Stimulation on GB 34 Activates Neural Responses Associated with Parkinson's Disease
Yeo, S., Lim, S., Choe, I., Choi, Y., Chung, K., Jahng, G., & Kim, S. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2012.00363.x · Cited by 60
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Parsing brain activity associated with acupuncture treatment in Parkinson's diseases
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Authors: Yeo, S., Choe, I.-H., van den Noort, M., Bosch, P., Jahng, G.-H., Rosen, B., Kim, S.-H., & Lim, S.
Affiliations: Kyung Hee University (KR)
Université Libre de Bruxelles (BE)
Radboud University Nijmegen (NL)
Harvard University (US)
Corresponding author: Lim, Sabina
ORCID: Yeo, Sujung
van den Noort, Maurits
Bosch, Peggy
Jahng, Geon-Ho
Rosen, Bruce
Kim, Sung-Hoon
Lim, Sabina
Venue: BMC Complementary and Alternative Medicine
Publisher: Springer Science and Business Media LLC
Published: 2014-09-15
Volume: 14
Issue: 1
Pages: 336-336
ISSN: 1472-6882 (ISSN-L)
DOI: 10.1186/1472-6882-14-336
PMC: PMC4175221
OpenAlex: W2139059366
Cited by: 64
References: 74
Citations by year: 2026: 5 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 4
FWCI: 10.03
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
www.springer.com/tdm (unspecified)
Locations: BMC Complementary and Alternative Medicine (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Radboud Repository (Radboud University) (submittedVersion)
VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion, other-oa)
Funders: National Research Foundation
National Research Foundation of Korea (2007-0054931)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Acupuncture Treatment Research Studies
Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Studies
Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords: acupuncture, Parkinson's disease, prefrontal cortex, precentral gyrus, putamen, brain activation, acupoint stimulation, motor function
MeSH terms: Adult, Aged, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Parkinson Disease, Acupuncture Points, Acupuncture Therapy, Case-Control Studies, Prefrontal Cortex

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Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson’s disease

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