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Some aspects of the mode of action of chlorhexidine
Abstract
Chlorhexidine is rapidly adsorbed by bacterial cells and this adsorption is accompanied by other cytological changes which include changes in the permeability of the cells and in their optical properties. The amount of drug adsorption causing maximum leakage of cell constituents and changes in extinction was found to be equivalent for Escherichia coli and for Staphylococcus aureus. Higher doses of chlorhexidine causing a higher level of drug adsorption caused correspondingly less leakage and change in extinction although such higher doses were more rapidly bactericidal.
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Citations
Cited by
Antiseptics and Disinfectants: Activity, Action, and Resistance
McDonnell, G., & Russell, A. D. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.1.147 · Cited by 4,780
Cationic antiseptics: diversity of action under a common epithet
Gilbert, P., & Moore, L. E. (2005) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2005.02664.x · Cited by 1,168
Carson, C. F., Mee, B. J., & Riley, T. V. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.6.1914-1920.2002 · Cited by 975
Mechanisms of action of antibacterial biocides
Denyer, S. P. (1995) · International Biodeterioration & Biodegradation · doi:10.1016/0964-8305(96)00015-7 · Cited by 324
Turgis, M., Han, J., Caillet, S., & Lacroix, M. (2009) · Food Control · doi:10.1016/j.foodcont.2009.02.001 · Cited by 236
Metadata
- Authors
- Hugo, W. B., & Longworth, A. R.
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 1964-10-01
- Volume
- 16
- Issue
- 10
- Pages
- 655-662
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W2010893628
- Cited by
- 321
- References
- 0
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hugo, W. B., & Longworth, A. R. (1964). Some aspects of the mode of action of chlorhexidine. Journal of Pharmacy and Pharmacology. https://doi.org/10.1111/j.2042-7158.1964.tb07384.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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