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The effect of chlorhexidine on the electrophoretic mobility, cytoplasmic constituents, dehydrogenase activity and cell walls of Escherichia coli and Staphylococcus aureus
Abstract
Chlorhexidine does not cause lysis of isolated cell walls, nor does it prevent the synthesis of the mucopeptide component of the cell wall. Low concentrations of the drug stimulate dehydrogenase activity but higher concentrations inhibit the activity. Chlorhexidine reacts with and precipitates proteinaceous and pentose-containing components of a solution of cell-free cytoplasmic constituents in concentrations greater than those causing their maximum leakage. The effect of chlorhexidine concentration on the electrophoretic mobility of bacterial cells is consistent with the hypothesis that the drug accumulates in aggregates at the cell surface rather than in the form of a monolayer or multilayers of drug.
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Citations
Cited by
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Cationic antiseptics: diversity of action under a common epithet
Gilbert, P., & Moore, L. E. (2005) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2005.02664.x · Cited by 1,168
Action of Disinfectant Quaternary Ammonium Compounds against Staphylococcus aureus
Ioannou, C. J., Hanlon, G. W., & Denyer, S. P. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00375-06 · Cited by 377
Wand, M. E., Bock, L. J., Bonney, L. C., & Sutton, J. M. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01162-16 · Cited by 313
Antiplaque and antigingivitis toothpastes
Sanz, M., Serrano, J., Iniesta, M., Santa Cruz, I., & Herrera, D. (2013) · Monographs in Oral Science · doi:10.1159/000350465 · Cited by 81
Metadata
- Authors
- HUGO, W. B., & LONGWORTH, A. R.
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 1966-09-01
- Volume
- 18
- Issue
- 9
- Pages
- 569-578
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W2080948852
- Cited by
- 183
- References
- 0
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The effect of chlorhexidine on the electrophoretic mobility, cytoplasmic constituents, dehydrogenase activity and cell walls of Escherichia coli and Staphylococcus aureus. https://app.cochat.ai/papers/10.1111/j.2042-7158.1966.tb07935.x
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- HUGO, W. B., & LONGWORTH, A. R. (1966). The effect of chlorhexidine on the electrophoretic mobility, cytoplasmic constituents, dehydrogenase activity and cell walls of Escherichia coli and Staphylococcus aureus. Journal of Pharmacy and Pharmacology. https://doi.org/10.1111/j.2042-7158.1966.tb07935.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
