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Intranasal drug delivery by spray and drops
Abstract
A solution of 99m Tc-labelled human serum albumin was administered into the nose as a spray and as one or three drops. The patterns of deposition and the rates of clearance in normal subjects were monitored by gamma scintigraphy. The spray was deposited mainly in the atrium, and cleared slowly into the pharynx. The single drop spread more extensively than the spray, while the three drops were sufficient to cover most of the walls of the nasal cavity. Clearance was faster following administration of the drops. These factors have implications when designing dosage regimens for drugs administered by the intranasal route.
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Cited by
Hayden, F. G., Osterhaus, A. D. M. E., Treanor, J. J., Fleming, D. M., Aoki, F. Y., Nicholson, K. G., Bohnen, A. M., Hirst, H. M., Keene, O., & Wightman, K. (1997) · New England Journal of Medicine · doi:10.1056/nejm199709253371302 · Cited by 762
Evaluation of intranasal delivery route of drug administration for brain targeting
Erdő, F., Bors, L. A., Farkas, D., Bajza, Á., & Gizurarson, S. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.10.009 · Cited by 744
Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review
Djupesland, P. G. (2013) · Drug Delivery and Translational Research · doi:10.1007/s13346-012-0108-9 · Cited by 563
Nasal mucociliary clearance as a factor in nasal drug delivery
Marttin, E., Schipper, N. G. M., Verhoef, J. C., & Merkus, F. W. H. M. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00059-8 · Cited by 469
Evaluation of the clearance characteristics of bioadhesive systems in humans
Soane, R. J., Frier, M., Perkins, A. C., Jones, N. S., Davis, S. S., & Illum, L. (1999) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(98)00367-6 · Cited by 360
Metadata
- Authors
- Hardy, J. G., Lee, S. W., & Wilson, C. G.
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-05-01
- Volume
- 37
- Issue
- 5
- Pages
- 294-297
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W2085264307
- Cited by
- 250
- References
- 0
- FWCI
- 9.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hardy, J. G., Lee, S. W., & Wilson, C. G. (1985). Intranasal drug delivery by spray and drops. Journal of Pharmacy and Pharmacology. https://doi.org/10.1111/j.2042-7158.1985.tb05069.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
