The DOI matches its Crossref record; 178 of the 178 references it cites were found in a registry or an index.
Evaluation of intranasal delivery route of drug administration for brain targeting
Open accessAbstract
The acute or chronic drug treatments for different neurodegenerative and psychiatric disorders are challenging from several aspects. The low bioavailability and limited brain exposure of oral drugs, the rapid metabolism, elimination, the unwanted side effects and also the high dose to be added mean both inconvenience for the patients and high costs for the patients, their family and the society. The reason of low brain penetration of the compounds is that they have to overcome the blood-brain barrier which protects the brain against xenobiotics. Intranasal drug administration is one of the promising options to bypass blood-brain barrier, to reduce the systemic adverse effects of the drugs and to lower the doses to be administered. Furthermore, the drugs administered using nasal route have usually higher bioavailability, less side effects and result in higher brain exposure at similar dosage than the oral drugs. In this review the focus is on giving an overview on the anatomical and cellular structure of nasal cavity and absorption surface. It presents some possibilities to enhance the drug penetration through the nasal barrier and summarizes some in vitro, ex vivo and in vivo technologies to test the drug delivery across the nasal epithelium into the brain. Finally, the authors give a critical evaluation of the nasal route of administration showing its main advantages and limitations of this delivery route for CNS drug targeting.
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Cites
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Cited by
Kellar, D., & Craft, S. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30231-3 · Cited by 832
The blood-brain barrier: Physiology and strategies for drug delivery
Pandit, R., Chen, L., & Götz, J. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.11.009 · Cited by 651
Solid Lipid Nanoparticles (SLNs): An Advanced Drug Delivery System Targeting Brain through BBB
Satapathy, M. K., Yen, T.-L., Jan, J.-S., Tang, R.-D., Wang, J.-Y., Taliyan, R., & Yang, C.-H. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081183 · Cited by 318
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Stimuli-responsive In situ gelling system for nose-to-brain drug delivery
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Metadata
- Authors
- Erdő, F., Bors, L. A., Farkas, D., Bajza, Á., & Gizurarson, S.
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 143
- Pages
- 155-170
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W2898588982
- Cited by
- 744
- References
- 178
- FWCI
- 22.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Erdő, F., Bors, L. A., Farkas, D., Bajza, Á., & Gizurarson, S. (2018). Evaluation of intranasal delivery route of drug administration for brain targeting. Brain Research Bulletin. https://doi.org/10.1016/j.brainresbull.2018.10.009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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