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Cited by 563Advanced Drug Delivery SystemsInhalation and Respiratory Drug DeliveryNasal Surgery and Airway Studies

Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review

Open access
Djupesland, Per Gisle·2013·Drug Delivery and Translational Research
DOI 10.1007/s13346-012-0108-9PMC PMC3539067
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Abstract

Nasal delivery is the logical choice for topical treatment of local diseases in the nose and paranasal sinuses such as allergic and non-allergic rhinitis and sinusitis. The nose is also considered an attractive route for needle-free vaccination and for systemic drug delivery, especially when rapid absorption and effect are desired. In addition, nasal delivery may help address issues related to poor bioavailability, slow absorption, drug degradation, and adverse events in the gastrointestinal tract and avoids the first-pass metabolism in the liver. However, when considering nasal delivery devices and mechanisms, it is important to keep in mind that the prime purpose of the nasal airway is to protect the delicate lungs from hazardous exposures, not to serve as a delivery route for drugs and vaccines. The narrow nasal valve and the complex convoluted nasal geometry with its dynamic cyclic physiological changes provide efficient filtration and conditioning of the inspired air, enhance olfaction, and optimize gas exchange and fluid retention during exhalation. However, the potential hurdles these functional features impose on efficient nasal drug delivery are often ignored. With this background, the advantages and limitations of existing and emerging nasal delivery devices and dispersion technologies are reviewed with focus on their clinical performance. The role and limitations of the in vitro testing in the FDA guidance for nasal spray pumps and pressurized aerosols (pressurized metered-dose inhalers) with local action are discussed. Moreover, the predictive value and clinical utility of nasal cast studies and computer simulations of nasal airflow and deposition with computer fluid dynamics software are briefly discussed. New and emerging delivery technologies and devices with emphasis on Bi-Directional™ delivery, a novel concept for nasal delivery that can be adapted to a variety of dispersion technologies, are described in more depth.

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Research works printed but not linked: 4

  1. [5]Cole P Nasal respiratory function. In: The nose 1993 St. Louis Mosby-Year Book Inc. 3 60
  2. [6]Cole P The mouth and the throat. In: The nose 1993 St. Louis Mosby-Year Book Inc. 61 90
  3. [102]Kleven M. Numerical simulations and experimental studies for nasal delivery of vaccines and drugs. Thesis. NTNU. 2012. ISBN:978-82-471-3398-9.
  4. [116]Bond W, Hardy JG, Wilson CG. Deposition and clearance of nasal sprays. In: Aiache JM, Hirtz J, editors. Proceedings volume I, Biopharmaceutics; 1985. pp. 93–8.

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Authors
Djupesland, P. G.
Affiliations
OptiNose (Norway) (NO)
Corresponding author
Djupesland, Per Gisle
ORCID
Djupesland, Per Gisle
Venue
Drug Delivery and Translational Research
Publisher
Springer Science and Business Media LLC
Published
2012-10-18
Volume
3
Issue
1
Pages
42-62
ISSN
  • 2190-393X (ISSN-L)
  • 2190-3948
DOI
10.1007/s13346-012-0108-9
PMC
PMC3539067
OpenAlex
W2045670750
Cited by
563
References
114
Citations by year
2026: 57 · 2025: 50 · 2024: 50 · 2023: 58 · 2022: 59 · 2021: 57 · 2020: 45 · 2019: 35 · 2018: 46 · 2017: 33 · 2016: 26 · 2015: 20 · 2014: 19 · 2013: 6
FWCI
8.93
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Drug Delivery and Translational Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
  • Health Sciences › Medicine › Surgery › Nasal Surgery and Airway Studies
Keywords
intranasal drug delivery, pressurized metered-dose inhaler, rhinitis, sinusitis, needle-free vaccination, first-pass metabolism avoidance, computational fluid dynamics

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