Subcellular Distribution of Metformin in Rat Liver

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works

Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue

Duve, C. D., Pressman, B. C., Gianetto, R., Wattiaux, R., & Appelmans, F. (1955) · Biochemical Journal · doi:10.1042/bj0600604 · Cited by 4,176 · see citing works

Metformin kinetics in healthy subjects and in patients with diabetes mellitus.

Tucker, G., Casey, C., Phillips, P., Connor, H., Ward, J. D., & Woods, H. (1981) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1981.tb01206.x · Cited by 497 · see citing works

Pharmacokinetics of Metformin After Intravenous and Oral Administration to Man

Pentik�inen, P. J., Neuvonen, P. J., & Penttil�, A. (1979) · European Journal of Clinical Pharmacology · doi:10.1007/bf00562061 · Cited by 348 · see citing works

Reduction of metformin renal tubular secretion by cimetidine in man.

Somogyi, A. A., Stockley, C. S., Keal, J., Rolan, P. E., & Bochner, F. (1987) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1987.tb03090.x · Cited by 281 · see citing works

Metformin Revisited: Its Actions and Indications for Use

Bailey, C. J. (1988) · Diabetic Medicine · doi:10.1111/j.1464-5491.1988.tb00996.x · Cited by 90 · see citing works

11 Treatment—metformin

Bailey, C. J., & Nattrass, M. (1988) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(88)80043-0 · Cited by 68 · see citing works

Reconsideration of inhibitory effect of metformin on intestinal glucose absorption

Wilcock, C., & Bailey, C. J. (1991) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1991.tb06645.x · Cited by 61 · see citing works

Guanidines and biguanides

Schäfer, G. (1980) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(80)90049-2 · Cited by 31 · see citing works

Fluorometric determination of DNA in fixed tissue using ethidium bromide

Andersen, K.-J., & Skagen, D. W. (1977) · Analytical Biochemistry · doi:10.1016/0003-2697(77)90075-6 · Cited by 27 · see citing works

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652 · see citing works

Metformin: An Old Drug for the Treatment of Diabetes But a New Drug for the Protection of the Endothelium

Kinaan, M., Ding, H., & Triggle, C. R. (2015) · Medical Principles and Practice · doi:10.1159/000381643 · Cited by 1,515 · see citing works

Clinical pharmacokinetics of metformin

Graham, G. G., Punt, J., Arora, M., Day, R. O., Doogue, M. P., Duong, J. K., Furlong, T. J., Greenfield, J. R., Greenup, L. C., Kirkpatrick, C. M., et al. (2011) · Clinical Pharmacokinetics · doi:10.2165/11534750-000000000-00000 · Cited by 1,318 · see citing works

Metformin Inhibits Hepatic Gluconeogenesis in Mice Independently of the LKB1/AMPK Pathway via a Decrease in Hepatic Energy State

Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, K., Andreelli, F., & Viollet, B. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40671 · Cited by 1,181 · see citing works

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

Foretz, M., Guigas, B., & Viollet, B. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0242-2 · Cited by 686 · see citing works

Biguanides and NIDDM

Bailey, C. J. (1992) · Diabetes Care · doi:10.2337/diacare.15.6.755 · Cited by 593 · see citing works

Metformin Inhibits Proinflammatory Responses and Nuclear Factor-κB in Human Vascular Wall Cells

Isoda, K., Young, J. L., Zirlik, A., MacFarlane, L. A., Tsuboi, N., Gerdes, N., Schönbeck, U., & Libby, P. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000201938.78044.75 · Cited by 499 · see citing works

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

Wang, Y., An, H., Liu, T., Qin, C., Sesaki, H., Guo, S., Radovick, S., Hussain, M., Maheshwari, A., Wondisford, F. E., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.070 · Cited by 432 · see citing works

Accumulation of Metformin by Tissues of the Normal and Diabetic Mouse

Wilcock, C., & Bailey, C. J. (1994) · Xenobiotica · doi:10.3109/00498259409043220 · Cited by 418 · see citing works

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide

Łabuzek, K., Suchy, D., Gabryel, B., Bielecka, A., Liber, S., & Okopień, B. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70357-1 · Cited by 405 · see citing works

Metformin Activates AMP-Activated Protein Kinase in Primary Human Hepatocytes by Decreasing Cellular Energy Status

Stephenne, X., Foretz, M., Taleux, N., van der Zon, G. C., Sokal, E., Hue, L., Viollet, B., & Guigas, B. (2011) · Diabetologia · doi:10.1007/s00125-011-2311-5 · Cited by 287 · see citing works

Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes

Dutta, S., Shah, R., Singhal, S., Dutta, S. B., Bansal, S., Sinha, S., & Haque, M. (2023) · Drug Design Development and Therapy · doi:10.2147/dddt.s409373 · Cited by 284 · see citing works

Metformin: Is it a drug for all reasons and diseases?

Triggle, C. R., Mohammed, I., Bshesh, K., Marei, I., Ye, K., Ding, H., MacDonald, R. S., Hollenberg, M. D., & Hill, M. A. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155223 · Cited by 282 · see citing works

A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan

Mohammed, I., Hollenberg, M. D., Ding, H., & Triggle, C. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.718942 · Cited by 278 · see citing works

Metformin-induced mitochondrial Complex I inhibition: facts, uncertainties, and consequences

Fontaine, E. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00753 · Cited by 269 · see citing works

Metformin and Systemic Metabolism

He, L. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.09.001 · Cited by 242 · see citing works

Metformin Rapidly Increases Insulin Receptor Activation in Human Liver and Signals Preferentially through Insulin-Receptor Substrate-2

Gunton, J. E., Delhanty, P. J. D., Takahashi, S., & Baxter, R. C. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021394 · Cited by 231 · see citing works

Lactic Acidosis Induced by Metformin

Lalau, J. (2010) · Drug Safety · doi:10.2165/11536790-000000000-00000 · Cited by 221 · see citing works

The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective

Agius, L., Ford, B. E., & Chachra, S. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093240 · Cited by 178 · see citing works

Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion

Leclerc, I., Woltersdorf, W. W. W., Xavier, G. D. S., Rowe, R. L., Cross, S. E., Korbutt, G. S., Rajotte, R. V., Smith, R. M., & Rutter, G. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00532.2003 · Cited by 171 · see citing works

Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes

Argaud, D., Roth, H., Wiernsperger, N. F., & Leverve, X. M. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb17886.x · Cited by 151 · see citing works

The Relationship between the Gut Microbiome and Metformin as a Key for Treating Type 2 Diabetes Mellitus

Lee, C. B., Chae, S. U., Jo, S. J., Jerng, U. M., & Bae, S. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073566 · Cited by 149 · see citing works

Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy

van Stee, M. F., de Graaf, A. A., & Groen, A. K. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0738-4 · Cited by 147 · see citing works

In Vivo Imaging of Human 11 C-Metformin in Peripheral Organs: Dosimetry, Biodistribution, and Kinetic Analyses

Gormsen, L. C., Sundelin, E. I. O., Jensen, J., Vendelbo, M. H., Jakobsen, S., Munk, O. L., Christensen, M. M. H., Brøsen, K., Frøkiær, J., & Jessen, N. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.177774 · Cited by 145 · see citing works

Effect of metformin on glucose metabolism in the splanchnic bed

Bailey, C. J., Wilcock, C., & Day, C. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09093.x · Cited by 130 · see citing works

Metformin—An update

Bailey, C. J. (1993) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(93)90411-p · Cited by 111 · see citing works

Metformin affects macrophages’ phenotype and improves the activity of glutathione peroxidase, superoxide dismutase, catalase and decreases malondialdehyde concentration in a partially AMPK-independent manner in LPS-stimulated human monocytes/macrophages

Bułdak, Ł., Łabuzek, K., Bułdak, R. J., Kozłowski, M., Machnik, G., Liber, S., Suchy, D., Duława, A., & Okopień, B. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2013.11.008 · Cited by 104 · see citing works

Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium

Triggle, C. R., & Ding, H. (2015) · Acta Physiologica · doi:10.1111/apha.12644 · Cited by 99 · see citing works

Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function

Détaille, D., Guigas, B., Leverve, X. M., Wiernsperger, N. F., & Devos, P. E. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)00858-4 · Cited by 97 · see citing works

Kinetics of plasma and erythrocyte metformin after acute administration in healthy subjects

Robert, F., Fendri, S., Hary, L., Lacroix, C., Andréjak, M., & Jd, L. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70037-x · Cited by 95 · see citing works

Metformin as Potential Therapy for High-Grade Glioma

Mazurek, M., Litak, J., Kamieniak, P., Kulesza, B., Jonak, K. E., Baj, J., & Grochowski, C. (2020) · Cancers · doi:10.3390/cancers12010210 · Cited by 88 · see citing works

Metabolic Action of Metformin

Szymczak-Pajor, I., Wenclewska, S., & Śliwińska, A. (2022) · Pharmaceuticals · doi:10.3390/ph15070810 · Cited by 81 · see citing works

Measurement of metformin concentration in erythrocytes:clinical implications

Lalau, J., & Lacroix, C. (2003) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2003.00241.x · Cited by 73 · see citing works

Metformin-induced Acute Hepatitis

Babich, M., Pike, I. M., & Shiffman, M. L. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00088-6 · Cited by 71 · see citing works

Metformin: From Diabetes to Cancer—Unveiling Molecular Mechanisms and Therapeutic Strategies

Amengual-Cladera, E., Morla-Barcelo, P. M., Morán-Costoya, A., Valle, A., Pons, D. G., Sastre‐Serra, J., Roca, P., & Nadal‐Serrano, M. (2024) · Biology · doi:10.3390/biology13050302 · Cited by 67 · see citing works

Cardiovascular impact of drugs used in the treatment of diabetes

Triggle, C. R., & Ding, H. (2014) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622314546125 · Cited by 66 · see citing works

The mechanism by which imeglimin inhibits gluconeogenesis in rat liver cells

Vial, G., Lamarche, F., Cottet‐Rousselle, C., Hallakou‐Bozec, S., Borel, A., & Fontaine, E. M. (2021) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.211 · Cited by 65 · see citing works

Metformin has adenosine-monophosphate activated protein kinase (AMPK)-independent effects on LPS-stimulated rat primary microglial cultures

Łabuzek, K., Liber, S., Gabryel, B., & Okopień, B. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70343-1 · Cited by 63 · see citing works

High Glucose Represses the Anti-Proliferative and Pro-Apoptotic Effect of Metformin in Triple Negative Breast Cancer Cells

Varghese, S., Samuel, S. M., Varghese, E., Kubatka, P., & Büsselberg, D. (2019) · Biomolecules · doi:10.3390/biom9010016 · Cited by 57 · see citing works

Impact of metformin on reproductive tissues: an overview from gametogenesis to gestation.

Bertoldo, M. J., Faure, M., Dupont, J., & Froment, P. (2014) · PubMed Central · doi:10.3978/j.issn.2305-5839.2014.06.04 · Cited by 56 · see citing works

Role of the AMPK pathway in promoting autophagic flux via modulating mitochondrial dynamics in neurodegenerative diseases: Insight into prion diseases

Shah, S. Z. A., Zhao, D., Hussain, T., & Yang, L. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.004 · Cited by 55 · see citing works

Metformin increases phagocytosis and acidifies lysosomal/endosomal compartments in AMPK-dependent manner in rat primary microglia

Łabuzek, K., Liber, S., Gabryel, B., Adamczyk, J., & Okopień, B. (2009) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-009-0477-x · Cited by 55 · see citing works

Metformin reduces endothelial cell expression of both the receptor for advanced glycation end products and lectin-like oxidized receptor 1

Ouslimani, N., Mahrouf‐Yorgov, M., Peynet, J., Bonnefont‐Rousselot, D., Cosson, C., Legrand, A., & Beaudeux, J. (2007) · Metabolism · doi:10.1016/j.metabol.2006.10.010 · Cited by 55 · see citing works

Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease

Triggle, C. R., Ding, H., Marei, I., Anderson, T. J., & Hollenberg, M. D. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2019-0677 · Cited by 49 · see citing works

Effects of metformin on glucose and glucagon regulated gluconeogenesis in cultured normal and diabetic hepatocytes

Yu, B., Pugazhenthi, S., & Khandelwal, R. L. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90365-4 · Cited by 44 · see citing works

The Gut Microbiota-Related Antihyperglycemic Effect of Metformin

Szymczak-Pajor, I., Drzewoski, J., Kozłowska, M., Krekora, J., & Śliwińska, A. (2025) · Pharmaceuticals · doi:10.3390/ph18010055 · Cited by 41 · see citing works

Metformin: Metabolic Rewiring Faces Tumor Heterogeneity

Cioce, M., Pulito, C., Strano, S., Blandino, G., & Fazio, V. M. (2020) · Cells · doi:10.3390/cells9112439 · Cited by 41 · see citing works

Metformin Represses Glucose Starvation Induced Autophagic Response in Microvascular Endothelial Cells and Promotes Cell Death

Samuel, S. M., Ghosh, S., Majeed, Y., Arunachalam, G., Emara, M. M., Ding, H., & Triggle, C. R. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.03.001 · Cited by 37 · see citing works

Transfer of metformin across monolayers of human intestinal Caco-2 cells and across rat intestine

Nicklin, P. L., Keates, A. C., Page, T., & Bailey, C. J. (1996) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(95)04259-8 · Cited by 37 · see citing works

Preclinical Pharmacology of Biguanides

Wiernsperger, N. F. (1996) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-09127-2_12 · Cited by 36 · see citing works

Alterations of Gut Microbiota by Overnutrition Impact Gluconeogenic Gene Expression and Insulin Signaling

He, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042121 · Cited by 34 · see citing works

Novel therapeutic mechanism of action of metformin and its nanoformulation in Alzheimer's disease and role of AKT/ERK/GSK pathway

Kumar, H., Chakrabarti, A., Sarma, P., Modi, M., Banerjee, D., Radotra, B. D., Bhatia, A., & Medhi, B. (2022) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2022.106348 · Cited by 32 · see citing works

Metformin exaggerates phenylephrine-induced AMPK phosphorylation independent of CaMKKβ and attenuates contractile response in endothelium-denuded rat aorta

Pyla, R., Osman, I., Pichavaram, P., Hansen, P., & Segar, L. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.08.024 · Cited by 28 · see citing works

The Hormetic Effect of Metformin: “Less Is More”?

Panfoli, I., Puddu, A., Bertola, N., Ravera, S., & Maggi, D. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126297 · Cited by 27 · see citing works

Metformin and intestinal glucose handling

Bailey, C. J. (1995) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610110505 · Cited by 27 · see citing works

Therapeutic vs. Suprapharmacological Metformin Concentrations: Different Effects on Energy Metabolism and Mitochondrial Function in Skeletal Muscle Cells in vitro

Pavlović, K., Jakovljevic, N. K., Isakovic, A. M., Ivanovic, T., Marković, I., & Lalic, N. M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.930308 · Cited by 26 · see citing works

AMP-activated protein kinase and its multifaceted regulation of hepatic metabolism

Fullerton, M. D. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000273 · Cited by 26 · see citing works

Regulation by metformin of the hexose transport system in vascular endothelial and smooth muscle cells

Sasson, S., Gorowits, N., Joost, H., King, G. L., Cerasi, E., & Kaiser, N. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb16731.x · Cited by 26 · see citing works

Uptake and Dispersion of Metformin in the Isolated Perfused Rat Liver

Chou, C. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001774732 · Cited by 23 · see citing works

Cholinergic and metabolic effects of metformin in mouse brain

Thinnes, A., Westenberger, M., Piechotta, C., Lehto, A., Wirth, F., Lau, H., & Klein, J. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.02.018 · Cited by 22 · see citing works

Effect of metformin on intact mitochondria from liver and brain: Concept revisited

Yoval‐Sánchez, B., Ansari, F., Lange, D., & Galkin, A. S. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175177 · Cited by 20 · see citing works

Metformin Prevents an Adaptive Increase in GSH and Induces Apoptosis Under the Conditions of GSH Deficiency in H4IIE Cells∗

Bae, E. J., Cho, M. J., & Kim, S. G. (2007) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390701434430 · Cited by 20 · see citing works

The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15

Kincaid, J. W. R., Rimmington, D., Tadross, J. A., Cimino, I., Zvetkova, I., Kaser, A., Richards, P., Patel, S., O’Rahilly, S., & Coll, A. P. (2024) · Scientific Reports · doi:10.1038/s41598-024-51866-2 · Cited by 19 · see citing works

Taxifolin-3-O-glucoside from Osbeckia nepalensis Hook. mediates antihyperglycemic activity in CC1 hepatocytes and in diabetic Wistar rats via regulating AMPK/G6Pase/PEPCK signaling axis

Gurumayum, S., Bharadwaj, S., Sheikh, Y., Barge, S., Saikia, K., Swargiary, D., Ahmed, S. A., Thakur, D., & Borah, J. C. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115936 · Cited by 18 · see citing works

Metformin Affects Heme Function as a Possible Mechanism of Action

Li, X., Wang, X., & Snyder, M. P. (2018) · G3 Genes Genomes Genetics · doi:10.1534/g3.118.200803 · Cited by 18 · see citing works

Metformin: A Promising Antidiabetic Medication for Cancer Treatment

Mu, W., Jiang, Y., Liang, G., Feng, Y., & Qu, F. (2022) · Current Drug Targets · doi:10.2174/1389450124666221104094918 · Cited by 18 · see citing works

Intracerebroventricular Metformin Decreases Body Weight But Has Pro-oxidant Effects and Decreases Survival

Portela, L. V., Gnoatto, J. A., Brochier, A., Haas, C. B., de Assis, A. M., de Carvalho, A. K., Hansel, G., Zimmer, E. R., Oses, J. P., & Muller, A. P. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1496-7 · Cited by 17 · see citing works

Metformin—mechanisms of its glycemia-reducing effect

Drewe, J., Foretz, M., & Krähenbühl, S. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100106 · Cited by 15 · see citing works

Free radical scavenging polyphenols isolated from Phyllanthus niruri L. ameliorates hyperglycemia via SIRT1 induction and GLUT4 translocation in in vitro and in vivo models

Swargiary, D., Kashyap, B., Sarma, P., Ahmed, S. A., Gurumayum, S., Barge, S., Basumatary, D., & Borah, J. C. (2024) · Fitoterapia · doi:10.1016/j.fitote.2023.105803 · Cited by 14 · see citing works

Metformin therapy in pediatric type 2 diabetes mellitus and its comorbidities: A review

Alfaraidi, H., & Samaan, M. C. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1072879 · Cited by 11 · see citing works

Repurposing Metformin for the Treatment of Atrial Fibrillation: Current Insights

Sarkar, A., Fanous, K., Marei, I., Ding, H., Ladjimi, M. M., MacDonald, R. S., Hollenberg, M. D., Anderson, T. J., Hill, M. A., & Triggle, C. R. (2024) · Vascular Health and Risk Management · doi:10.2147/vhrm.s391808 · Cited by 11 · see citing works

Metformin: Antidiabetic actions from cells to tissues

Bailey, C. J., Gwilt, M., & Brand, K. M. G. (2026) · Metabolism · doi:10.1016/j.metabol.2026.156589 · Cited by 10 · see citing works

Metformin Treatment Leads to Increased HIV Transcription and Gene Expression through Increased CREB Phosphorylation and Recruitment to the HIV LTR Promoter

Rezaei, S., Timani, K. A., & He, J. J. (2023) · Aging and Disease · doi:10.14336/ad.2023.0705 · Cited by 10 · see citing works

Comparison of Hepatic Transporter Tissue Expression in Rodents and Interspecies Hepatic OCT1 Activity

Morse, B. L., Fallon, J. K., Kolur, A., Hogan, A. T., Smith, P. C., & Hillgren, K. M. (2021) · The AAPS Journal · doi:10.1208/s12248-021-00583-z · Cited by 9 · see citing works

Impact of currently used anti-diabetic drugs on myoendothelial communication

Ding, H., Ye, K., & Triggle, C. R. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.11.002 · Cited by 9 · see citing works

Mechanistic understanding of the effect of renal impairment on metformin oral absorption using computer simulations

Almukainzi, M., Gabr, R., Abdelhamid, G., & Löbenberg, R. (2017) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-017-0307-y · Cited by 9 · see citing works

SIMPLE HPLC-UV METHOD FOR DETERMINATION OF METFORMIN IN HUMAN PLASMA AND ERYTHROCYTES APPLICATION TO THERAPEUTIC DRUG MONITORING

Abdessadek, M., Tadmori, A. E., Attari, A. E., Diarra, M., Magoul, R., Ajdi, F., Ouezzani, S. E., & Khabbal, Y. (2015) · International Journal of Pharmacy and Pharmaceutical Sciences · Cited by 7 · see citing works

The effect of metformin on liver blood flow in vivo in normal subjects and patients with non insulin dependent diabetes

Signore, A., Fiore, V., Chianelli, M., Procaccini, E., Barone, R., Ronga, G., Negri, M., & Pozzilli, P. (1996) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(96)01280-6 · Cited by 5 · see citing works

The Anticancer Effect of Metformin, the Most Commonly Used Anti-Diabetes Drug

Meng, S. (2014) · Cited by 4 · see citing works

Effect of metformin on liver insulin metabolism and regional blood flow

Signore, A., Fiore, V., Chianelli, M., Ronga, G., & Pozzilli, P. (1995) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610110504 · Cited by 4 · see citing works

Metformin in Diabetes and Beyond: Therapeutic Mechanisms, Lactic Acidosis, Organ-Specific Effects, and Nanotechnology-Based Delivery Strategies

Girigoswami, K., & Girigoswami, A. (2026) · Current Medical Science · doi:10.1007/s11596-026-00198-5 · Cited by 2 · see citing works

Combined Effect of Metformin and Statin

Sabu, M. C., & Thekkekara, P. T. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.100894 · Cited by 2 · see citing works

The coordinated actions of metformin in the intestine and liver improves hyperglycemia

He, L., An, H., Ramirez, K., Radovick, S., & Wondisford, F. E. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117791 · Cited by 1 · see citing works

Metformin: an old drug with potential therapeutic function in antitumorPreprint

Mu, W., Jiang, Y., & Qu, F. (2021) · doi:10.22541/au.163640852.26812577/v1

Metformin & Chronic Kidney Disease (CKD) : a reassessment of the benefit/risk ratio

Kajbaf, F. (2015) · theses.fr (ABES) · doi:10.70675/7a26b581z94ddz4e2fz9a48z97f6f7d8354a

Uptake and Dispersion of Metformin in the Isolated Perfused Rat Liver

Chou, C. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001774732 · Cited by 23 · see citing works

Pharmacokinetics and tissues distribution of metformin in rats

Zheng, Z. (2008) · Chinese Journal of New Drugs and Clinical Remedies

ASSESSMENT OF METFORMIN LEVELS IN RAT LIVER TISSUE AFTER ADMIN-ISTRATION BY DIFFERENT ROUTES

Obukhova, D. A., Tarakanova, O., Muruzheva, Z., & Karpenko, M. N. (2025) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.18070618

The subcellular distribution of 14C-lidamidine and its metabolites.

Procaccini, R. L., & Klunk, L. J. (1981) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)06129-x · Cited by 4 · see citing works

Distribution of caffeine and metabolites in brain and liver subcellular fractions in the rat

Galli, C. L., & Spagnuolo, C. (1975) · Pharmacological Research Communications · doi:10.1016/s0031-6989(75)80016-6 · Cited by 4 · see citing works