The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Inhibition of Intestinal Motility and Secretion by Flavonoids in Mice and Rats: Structure-activity Relationships
Abstract
Intraperitoneal administration of some flavonoids (apigenin, flavone, kaempferol, morin, myricetin, naringin and rutin; 12·5–50 mg kg−1) significantly (P < 0·05–0·01) reduced small (28–69%) and large (83–134%) intestinal transit in mice. Other flavonoids (naringenin, silibinin, silymarin and taxifolin, 100–200 mg kg−1) reduced (23–41%; P < 0·5–0·01) intestinal transit at doses of 100–200 mg kg−1 while hesperitin, catechin and phloridzin (up to 200 mg kg−1) had no effect. This effect was antagonized by yohimbine (87–96%) and phentolamine (87–91%) but not by prazosin, propranolol, atropine, hexamethonium, mepyramine, cyproheptadine and naloxone. Yohimbine (92–96%) also antagonized the inhibitory effect of flavonols (12·5–50 mg kg−1) (P < 0·05–0·01) on intraluminal accumulation of fluid and diarrhoea induced by castor oil. By contrast, verapamil potentiated the flavonol effect. It is suggested that these effects, influenced by the structure of the molecules, are mediated by α2-adrenergic receptors and calcium.
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Citations
Cites
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Cited by
Flavonoids: Old and new aspects of a class of natural therapeutic drugs
Di Carlo, G., Mascolo, N., Izzo, A. A., & Capasso, F. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00120-4 · Cited by 1,307
Self-citationFlavonoids as Nutraceuticals: A Review
Tapas, A., Sakarkar, D., & Kakde, R. (2008) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v7i3.14693 · Cited by 802
A Review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.)
McKay, D. L., & Blumberg, J. B. (2006) · Phytotherapy Research · doi:10.1002/ptr.1900 · Cited by 676
Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta
Ajay, M., Gilani, A.-U. H., & Mustafa, M. R. (2003) · Life Sciences · doi:10.1016/j.lfs.2003.06.039 · Cited by 262
Antiproliferative and palliative activity of flavonoids in colorectal cancer
Fernández, J., Silván, B., Entrialgo-Cadierno, R., Villar, C. J., Capasso, R., Uranga, J. A., Lombó, F., & Abalo, R. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112241 · Cited by 258
Metadata
- Authors
- Di Carlo, G., Autore, G., Izzo, A. A., Maiolino, P., Mascolo, N., Viola, P., Diurno, M. V., & Capasso, F.
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-12-01
- Volume
- 45
- Issue
- 12
- Pages
- 1054-1059
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W2038462428
- Cited by
- 277
- References
- 10
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Di Carlo, G., Autore, G., Izzo, A. A., Maiolino, P., Mascolo, N., Viola, P., Diurno, M. V., & Capasso, F. (1993). Inhibition of Intestinal Motility and Secretion by Flavonoids in Mice and Rats: Structure-activity Relationships. Journal of Pharmacy and Pharmacology. https://doi.org/10.1111/j.2042-7158.1993.tb07180.x
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