The DOI matches its Crossref record; 232 of the 232 references it cites were found in a registry or an index.
The neurobiology of central sensitization
Open accessAbstract
Central sensitization refers to the amplification of pain by central nervous system mechanisms. Classically described as a consequence of ongoing nociceptive input, it is increasingly recognized that central sensitization also occurs independent of peripheral injury or inflammation. Features of central sensitization have been identified in nearly all chronic pain conditions, and it is considered the primary underlying cause of pain in conditions such as fibromyalgia. Central sensitization is characterized in these conditions by widespread pain and multisite hyperalgesia/allodynia. Co‐occurring symptoms include fatigue, mood and cognitive problems, sleep disturbances, and multisensory hypersensitivity. Individuals with central sensitization often report previous exposure to psychosocial or physical stressors, and a higher personal lifetime and family history of pain, with the latter findings supported by genetic studies. Neuroimaging studies of central sensitization show evidence of: changes in brain gray matter in pain processing regions; neurochemical imbalances; and altered resting brain‐network connectivity between pronociceptive and antinociceptive brain areas. Immune system abnormalities have also been demonstrated in individuals with central sensitization. The recognition of central sensitization, and whether it is being driven by ongoing nociceptive input or it is occurring in the absence of a peripheral driver, is critical for effective pain management.
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Cites
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
Central sensitization: implications for the diagnosis and treatment of pain
Woolf, C. J. (2011) · Pain · doi:10.1016/j.pain.2010.09.030 · Cited by 4,771
Wolfe, F., Clauw, D. J., Fitzcharles, M., Goldenberg, D. L., Katz, R. S., Mease, P., Russell, A. S., Russell, I. J., Winfield, J. B., & Yunus, M. B. (2010) · Arthritis Care & Research · doi:10.1002/acr.20140 · Cited by 3,952
Self-citation2016 revisions to the 2010/2011 fibromyalgia diagnostic criteria
Wolfe, F., Clauw, D. J., Fitzcharles, M.-A., Goldenberg, D. L., Häuser, W., Katz, R. L., Mease, P. J., Russell, A. S., Russell, I. J., & Walitt, B. (2016) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2016.08.012 · Cited by 2,232
Self-citationEvidence for a central component of post-injury pain hypersensitivity
Woolf, C. J. (1983) · Nature · doi:10.1038/306686a0 · Cited by 2,157
Fibromyalgia: A Clinical Review
Clauw, D. J. (2014) · JAMA · doi:10.1001/jama.2014.3266 · Cited by 1,674
Self-citationAn fMRI-Based Neurologic Signature of Physical Pain
Wager, T. D., Atlas, L. Y., Lindquist, M. A., Roy, M., Woo, C.-W., & Kross, E. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1204471 · Cited by 1,597
WOLFE, F., CLAUW, D. J., FITZCHARLES, M.-A., GOLDENBERG, D. L., HÄUSER, W., KATZ, R. S., MEASE, P., RUSSELL, A. S., RUSSELL, I. J., & WINFIELD, J. B. (2011) · The Journal of Rheumatology · doi:10.3899/jrheum.100594 · Cited by 1,499
Self-citationDiffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat
Le Bars, D., Dickenson, A. H., & Besson, J.-M. (1979) · Pain · doi:10.1016/0304-3959(79)90049-6 · Cited by 1,364
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia
Gracely, R. H., Petzke, F., Wolf, J. M., & Clauw, D. J. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10225 · Cited by 1,263
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Microglia polarization in nociplastic pain: mechanisms and perspectives
Atta, A. A., Ibrahim, W. W., Mohamed, A. F., & Abdelkader, N. F. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01216-x · Cited by 178
Cannabinoids in Chronic Pain: Therapeutic Potential Through Microglia Modulation
van den Hoogen, N. J., Harding, E. K., Davidson, C. E. D., & Trang, T. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.816747 · Cited by 45
Central Sensitization in Chronic Pain and Eating Disorders: A Potential Shared Pathogenesis
Sim, L., Harbeck Weber, C., Harrison, T., & Peterson, C. (2021) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-019-09685-5 · Cited by 41
Chronic overlapping pain conditions and nociplastic pain
Johnston, K. J. A., Signer, R., & Huckins, L. M. (2025) · Human Genetics and Genomics Advances · doi:10.1016/j.xhgg.2024.100381 · Cited by 35
Behnoush, A. H., Khalaji, A., Khanmohammadi, S., Alehossein, P., Saeedian, B., Shobeiri, P., Teixeira, A. L., & Rezaei, N. (2023) · PLOS ONE · doi:10.1371/journal.pone.0296103 · Cited by 24
Metadata
- Authors
- Harte, S. E., Harris, R. E., & Clauw, D. J.
- Venue
- Journal of Applied Biobehavioral Research
- Publisher
- Wiley
- Published
- 2018-06
- Volume
- 23
- Issue
- 2
- ISSN
- 1071-2089 (ISSN-L)
- 1751-9861
- OpenAlex
- W2809860699
- Cited by
- 394
- References
- 232
- FWCI
- 14.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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